Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model Article Swipe

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John Jeffers , Emília M. Pinto , Jerold E. Rehg , Michael R. Clay , Jinling Wang , Geoffrey Neale , Richard J. Heath , Guillermina Lozano , Enzo Lalli , Bonald C. Figueiredo , Alberto S. Pappo , Carlos Rodríguez‐Galindo , Wenan Chen , Stanley Pounds , Raul C. Ribeiro , Gerard P. Zambetti ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/0008-5472.22430460

Mutant p53-R334H has a prolonged half-life and compromised in forming stable tetramers in primary mouse embryo fibroblasts.

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Penetrance Germline Germline mutation Genetics Mutation Cancer research Biology Gene Phenotype

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/0008-5472.22430460
OA Status: gold
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DOI: https://doi.org/10.1158/0008-5472.22430460

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Title: Supplementary Figure S8 from The Common Germline <i>TP53-R337H</i> Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model

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Type: preprint

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Language: en

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Publication year: 2023

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Publication date: 2023-03-31

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Authors: John Jeffers, Emília M. Pinto, Jerold E. Rehg, Michael R. Clay, Jinling Wang, Geoffrey Neale, Richard J. Heath, Guillermina Lozano, Enzo Lalli, Bonald C. Figueiredo, Alberto S. Pappo, Carlos Rodríguez‐Galindo, Wenan Chen, Stanley Pounds, Raul C. Ribeiro, Gerard P. Zambetti

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Landing page: https://doi.org/10.1158/0008-5472.22430460

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Open access: Yes

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OA status: gold

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OA URL: https://doi.org/10.1158/0008-5472.22430460

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Concepts: Penetrance, Germline, Germline mutation, Genetics, Mutation, Cancer research, Biology, Gene, Phenotype

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