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Olaf Klingbeil , Damianos Skopelitis , Claudia Tonelli , Toyoki Yoshimoto , Aktan Alpsoy , Maria C. Panepinto , Francesca Minicozzi , Joseph R. Merrill , Amanda M. Cafiero , Disha Aggarwal , Suzanne Russo , Taehoon Ha , Osama E. Demerdash , Tse-Luen Wee , David L. Spector , Scott K. Lyons , David A. Tuveson , Paolo Cifani , Christopher R. Vakoc ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1158/2159-8290.27938726

A, Sanger sequencing Chromatogram of NF2 locus in MDA-MB231 cells. B, C, Rescue experiment of MARK2+3dKO in Cas9+ YAPC cells following knockout of indicated genes. Data shown are the mean ± SD of %GFP+ (normalized to day 3 after infection). n=3. P values are calculated using a mixed effects model (considering the interaction of experimental groups over time) compared to Ctrl group and corrected with Bonferroni-Holm (BH). D, Western blot analysis of NF2 in A549 and MDA-MB231 cells. E, Rescue experiment of MARK2+3dKO in Cas9+ A549 following knockout of NF2 and expression of CRISPR resistant mutant NF2 cDNAs followed by knockout of indicated genes. Data shown are the mean ± SD of %GFP+ (normalized to day 3 after infection). n=3. P values are calculated using a mixed effects model (considering the interaction of experimental groups over time) compared to NFKO group and corrected with Bonferroni-Holm (BH).

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Processivity Mutant Kinase Sanger sequencing Molecular biology CRISPR Biology Gene Apoptosis Genetics DNA polymerase Mutation

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/2159-8290.27938726
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DOI: https://doi.org/10.1158/2159-8290.27938726

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Title: Supplementary Figure S9 from MARK2/MARK3 Kinases Are Catalytic Codependencies of YAP/TAZ in Human Cancer

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Language: en

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Publication year: 2024

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Publication date: 2024-12-02

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Authors: Olaf Klingbeil, Damianos Skopelitis, Claudia Tonelli, Toyoki Yoshimoto, Aktan Alpsoy, Maria C. Panepinto, Francesca Minicozzi, Joseph R. Merrill, Amanda M. Cafiero, Disha Aggarwal, Suzanne Russo, Taehoon Ha, Osama E. Demerdash, Tse-Luen Wee, David L. Spector, Scott K. Lyons, David A. Tuveson, Paolo Cifani, Christopher R. Vakoc

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Landing page: https://doi.org/10.1158/2159-8290.27938726

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Concepts: Processivity, Mutant, Kinase, Sanger sequencing, Molecular biology, CRISPR, Biology, Gene, Apoptosis, Genetics, DNA polymerase, Mutation

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