Supplementary Figures 1 - 9 from Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress Article Swipe

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Jun Aoi , Motoyoshi Endo , Tsuyoshi Kadomatsu , Keishi Miyata , Aki Ogata , Haruki Horiguchi , Haruki Odagiri , Tetsuro Masuda , Satoshi Fukushima , Masatoshi Jinnin , Satoshi Hirakawa , Tomohiro Sawa , Takaaki Akaike , Hironobu Ihn , Yuichi Oike ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/1541-7786.22511001

PDF file - 1314K, Supp Fig 1. Oxidative stress-dependent formation of 4-HNE and HNE-modified proteins. Supp Fig 2. NAC treatment decreases susceptibility of wild-type mice to chemical skin carcinogenesis. Supp Fig 3. Chemical treatment of Angptl2 KO mice does not alter Msh2 expression. Supp Fig 4. Levels of various DNA repair proteins in skin of wild-type versus K14-Angptl2 Tg mice. Supp Fig 5. Levels of various DNA repair proteins in skin of wild-type versus Angptl2 KO mice. Supp Fig 6. Levels of various DNA repair proteins in skin of Angptl2 Tg mice with or without NAC treatment. Supp Fig 7. Msh2 expression is ameliorated by antioxidant treatment of chemically-treated wild-type mice. Supp Fig 8. MSH levels are inversely correlated with ANGPTL2 expression in human tissues exhibiting actinic keratosis. Supp Fig 9. Mechanistic model of carcinogenesis accelerated by Angptl2.

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Oxidative stress Carcinogenesis Inflammation Chemistry Molecular biology Antioxidant Medicine Biology Biochemistry Immunology Gene

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Language: en
Landing Page: https://doi.org/10.1158/1541-7786.22511001
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Title: Supplementary Figures 1 - 9 from Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress

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Publication year: 2023

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Authors: Jun Aoi, Motoyoshi Endo, Tsuyoshi Kadomatsu, Keishi Miyata, Aki Ogata, Haruki Horiguchi, Haruki Odagiri, Tetsuro Masuda, Satoshi Fukushima, Masatoshi Jinnin, Satoshi Hirakawa, Tomohiro Sawa, Takaaki Akaike, Hironobu Ihn, Yuichi Oike

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Concepts: Oxidative stress, Carcinogenesis, Inflammation, Chemistry, Molecular biology, Antioxidant, Medicine, Biology, Biochemistry, Immunology, Gene

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