Supplementary Figures from E7386, a Selective Inhibitor of the Interaction between β-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling Article Swipe

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Kazuhiko Yamada , Yusaku Hori , Satoshi Inoue , Yuji Yamamoto , Kentaro Iso , Hiroshi Kamiyama , Atsumi Yamaguchi , Takayuki Kimura , Mai Uesugi , Jun‐ichi Ito , Masahiro Matsuki , Kazutaka Nakamoto , Hitoshi Harada , Naoki Yoneda , Atsushi Takemura , Ikuo Kushida , Naomi Wakayama , Kenji Kubara , Yu Kato , Taro Semba , Akira Yokoi , Masayuki Matsukura , Takenao Odagami , Masao Iwata , Akihiko Tsuruoka , Toshimitsu Uenaka , Junji Matsui , Tomohiro Matsushima , K. Nomoto , Hiroyuki Kouji , Takashi Owa , Yasuhiro Funahashi , Yoichi Ozawa ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/0008-5472.22427421

Supplementary Figures 1-9. Supplementary Fig. S1 Wnt/β-catenin-dependent reporter activity in ECC10 cells. Supplementary Fig. S2 Effect of E7386 on the interaction between β-catenin and p300 in ECC10 cells. Supplementary Fig. S3 Comparison of IC50 values among β-catenin/CBP inhibitors, as determined by HEK-293 TCF/LEF reporter assay. Supplementary Fig. S4 Upstream regulators of gene expression changes in whisker follicle tissues of ApcMin/+ mice treated with E7386. Supplementary Fig. S5 Inhibitory activity of E7386 against cell growth in ECC10 cells. Supplementary Fig. S6 Antitumor activity of E7386 and ICG-001 in a human ECC10 gastric tumor xenograft model. Supplementary Fig. S7 Gating strategy for the flow cytometry analysis of myeloid and T-cell populations. Supplementary Fig. S8 Flow cytometry analysis of the effect of E7386 on immune cell populations in the MMTV-Wnt1 model. Supplementary Fig. S9 Effect of PRI-724 on spontaneous intestinal polyp formation in ApcMin/+ mice.

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Wnt signaling pathway Chemistry Flow cytometry HEK 293 cells Molecular biology Catenin Cancer research Cell biology Biology Signal transduction Gene Biochemistry

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/0008-5472.22427421
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Title: Supplementary Figures from E7386, a Selective Inhibitor of the Interaction between β-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling

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Authors: Kazuhiko Yamada, Yusaku Hori, Satoshi Inoue, Yuji Yamamoto, Kentaro Iso, Hiroshi Kamiyama, Atsumi Yamaguchi, Takayuki Kimura, Mai Uesugi, Jun‐ichi Ito, Masahiro Matsuki, Kazutaka Nakamoto, Hitoshi Harada, Naoki Yoneda, Atsushi Takemura, Ikuo Kushida, Naomi Wakayama, Kenji Kubara, Yu Kato, Taro Semba, Akira Yokoi, Masayuki Matsukura, Takenao Odagami, Masao Iwata, Akihiko Tsuruoka, Toshimitsu Uenaka, Junji Matsui, Tomohiro Matsushima, K. Nomoto, Hiroyuki Kouji, Takashi Owa, Yasuhiro Funahashi, Yoichi Ozawa

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Concepts: Wnt signaling pathway, Chemistry, Flow cytometry, HEK 293 cells, Molecular biology, Catenin, Cancer research, Cell biology, Biology, Signal transduction, Gene, Biochemistry

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