Supplementary Figures from Liposome-Encapsulated Eribulin Shows Enhanced Antitumor Activity over Eribulin for Combination Therapy with Anti–PD-1 Antibody Article Swipe

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Yuki Niwa , Keito Adachi , Kimiyo Tabata , Ryoga Ishida , Koichiro Hotta , Tomomi Ishida , Yuji Mano , Yoichi Ozawa , Yukinori Minoshima , Yasuhiro Funahashi , Taro Semba ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/1535-7163.22495299.v1

Fig S1 shows isotype control has no antitumor activity. Fig S2 shows gating strategy for flow cytometric analysis of TILs. Fig S3 shows induction of ICAM-1 by eribulin. Fig S4 shows establishment of P-gp KO cell lines and ICD activity of eribulin. Fig S5 shows dose-dependent antitumor activity of eribulin-LF + anti-PD-1 Ab. Fig S6 shows PK analysis of eribulin and eribulin-LF in plasma and tumor. Fig S7 shows immunomodulatory activity of eribulin in different 3 regimens. Fig S8 shows TIL population changes not included in the main figures. Fig S9 shows activation of IFN signature by eribulin-LF.

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Eribulin Medicine Cancer research Internal medicine Pharmacology Cancer Metastatic breast cancer Breast cancer

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/1535-7163.22495299.v1
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DOI: https://doi.org/10.1158/1535-7163.22495299.v1

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Title: Supplementary Figures from Liposome-Encapsulated Eribulin Shows Enhanced Antitumor Activity over Eribulin for Combination Therapy with Anti–PD-1 Antibody

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Type: preprint

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Language: en

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Publication year: 2023

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Publication date: 2023-04-03

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Authors: Yuki Niwa, Keito Adachi, Kimiyo Tabata, Ryoga Ishida, Koichiro Hotta, Tomomi Ishida, Yuji Mano, Yoichi Ozawa, Yukinori Minoshima, Yasuhiro Funahashi, Taro Semba

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Landing page: https://doi.org/10.1158/1535-7163.22495299.v1

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Concepts: Eribulin, Medicine, Cancer research, Internal medicine, Pharmacology, Cancer, Metastatic breast cancer, Breast cancer

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