Supplementary Figures S1 - S6 from Bruton Tyrosine Kinase–Dependent Immune Cell Cross-talk Drives Pancreas Cancer Article Swipe

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Bruton's tyrosine kinase Cancer research Immune system Pancreatic cancer Tyrosine kinase Molecular biology Cancer Biology Medicine Internal medicine Immunology Signal transduction Cell biology

Andrew J. Gunderson , Megan M. Kaneda , Takahiro Tsujikawa , Abraham V. Nguyen , Nesrine I. Affara , Brian Ruffell , Sara Gorjestani , Shannon M. Liudahl , Morgan Truitt , Peter Olson , Grace Kim , Douglas Hanahan , Margaret A. Tempero , Brett C. Sheppard , Bryan Irving , Betty Chang , Judith A. Varner , Lisa M. Coussens ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/2159-8290.22530965.v1 · OA: W4362626943

<p>Supplementary Figure S1. B cells in human PDAC. Supplementary Figure S2. B cells and FcRgamma-positive cells regulate murine PDAC. Supplementary Figure S3. Leukocytes and BTK in human and murine PDAC. Supplementary Figure S4. Macrophage PI3Kgamma activates BTK to promote PDAC progression. Supplementary Figure S5. BTK and PI3Kgamma-inhibition decrease PDAC growth. Supplementary Figure S6. BTK inhibition improves gemcitabine response in late-stage PDAC.</p>