Supplementary File S14 from Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator Article Swipe

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Anna M. Puzio‐Kuter , Lizhong Xu , Mary Kate McBrayer , Romyr Dominique , Hongju H. Li , Bruce J. Fahr , Alyssa M. Brown , Amy E. Wiebesiek , Brandon M. Russo , Chris L. Mulligan , Hong Yang , Josh Battaglia , Kimberly A. Robell , Dafydd H. Thomas , Kuo‐Sen Huang , Alexander Solovyov , Benjamin D. Greenbaum , Jonathan D. Oliner , Thomas W. Davis , Melissa Dumble , Melissa L. Johnson , Shunbin Xiong , Peirong Yang , Guillermina Lozano , Marc Fellous , Binh T. Vu , Alison M. Schram , Arnold J. Levine , Masha V. Poyurovsky ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1158/2159-8290.29221453

GSEA analysis of DEGs shows the restoration of WT p53 transcriptional responses by PC14586 in vivo in NUGC-3 xenografted tumors over 6 days of 100-mg/kg PC14586.

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Suppressor Mutant Function (biology) Process (computing) Cancer research Biology Computer science Cell biology Genetics Operating system Cancer Gene

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/2159-8290.29221453
OA Status: gold
Related Works: 10
OpenAlex ID: https://openalex.org/W4411003489

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DOI: https://doi.org/10.1158/2159-8290.29221453

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Title: Supplementary File S14 from Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator

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Language: en

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Publication year: 2025

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Publication date: 2025-06-03

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Authors: Anna M. Puzio‐Kuter, Lizhong Xu, Mary Kate McBrayer, Romyr Dominique, Hongju H. Li, Bruce J. Fahr, Alyssa M. Brown, Amy E. Wiebesiek, Brandon M. Russo, Chris L. Mulligan, Hong Yang, Josh Battaglia, Kimberly A. Robell, Dafydd H. Thomas, Kuo‐Sen Huang, Alexander Solovyov, Benjamin D. Greenbaum, Jonathan D. Oliner, Thomas W. Davis, Melissa Dumble, Melissa L. Johnson, Shunbin Xiong, Peirong Yang, Guillermina Lozano, Marc Fellous, Binh T. Vu, Alison M. Schram, Arnold J. Levine, Masha V. Poyurovsky

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Landing page: https://doi.org/10.1158/2159-8290.29221453

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Concepts: Suppressor, Mutant, Function (biology), Process (computing), Cancer research, Biology, Computer science, Cell biology, Genetics, Operating system, Cancer, Gene

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