Supplementary Material and Methods from IRS2 Copy Number Gain, KRAS and BRAF Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines Article Swipe

View

Fei Huang , Han Chang , Ann Greer , Stephen Hillerman , Karen A. Reeves , Warren Hurlburt , John Cogswell , Dharmesh Patel , Zhenhao Qi , Craig R. Fairchild , Rolf-Peter Ryseck , Tai W. Wong , Friedrich Graf Finckenstein , Jeffrey L. Jackson , Joan M. Carboni ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/1535-7163.22503655.v1

Material and Methods

Related Topics

Kras

Mutation

Biology

Concepts

KRAS Mutation Cancer research Biology Genetics Gene

Metadata

Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/1535-7163.22503655.v1
OA Status: gold
Related Works: 10
OpenAlex ID: https://openalex.org/W4362622305

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4362622305

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1158/1535-7163.22503655.v1

Digital Object Identifier
Title: Supplementary Material and Methods from IRS2 Copy Number Gain, KRAS and BRAF Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines

Work title
Type: preprint

OpenAlex work type
Language: en

Primary language
Publication year: 2023

Year of publication
Publication date: 2023-04-03

Full publication date if available
Authors: Fei Huang, Han Chang, Ann Greer, Stephen Hillerman, Karen A. Reeves, Warren Hurlburt, John Cogswell, Dharmesh Patel, Zhenhao Qi, Craig R. Fairchild, Rolf-Peter Ryseck, Tai W. Wong, Friedrich Graf Finckenstein, Jeffrey L. Jackson, Joan M. Carboni

List of authors in order
Landing page: https://doi.org/10.1158/1535-7163.22503655.v1

Publisher landing page
Open access: Yes

Whether a free full text is available
OA status: gold

Open access status per OpenAlex
OA URL: https://doi.org/10.1158/1535-7163.22503655.v1

Direct OA link when available
Concepts: KRAS, Mutation, Cancer research, Biology, Genetics, Gene

Top concepts (fields/topics) attached by OpenAlex
Cited by: 0

Total citation count in OpenAlex
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4362622305
doi	https://doi.org/10.1158/1535-7163.22503655.v1
ids.doi	https://doi.org/10.1158/1535-7163.22503655.v1
ids.openalex	https://openalex.org/W4362622305
fwci	0.0
type	preprint
title	Supplementary Material and Methods from <i>IRS2</i> Copy Number Gain, <i>KRAS</i> and <i>BRAF</i> Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
topics[0].id	https://openalex.org/T11067
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	0.97079998254776
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2730
topics[0].subfield.display_name	Oncology
topics[0].display_name	Colorectal Cancer Treatments and Studies
topics[1].id	https://openalex.org/T10631
topics[1].field.id	https://openalex.org/fields/13
topics[1].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[1].score	0.958899974822998
topics[1].domain.id	https://openalex.org/domains/1
topics[1].domain.display_name	Life Sciences
topics[1].subfield.id	https://openalex.org/subfields/1306
topics[1].subfield.display_name	Cancer Research
topics[1].display_name	Cancer, Hypoxia, and Metabolism
topics[2].id	https://openalex.org/T12996
topics[2].field.id	https://openalex.org/fields/13
topics[2].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[2].score	0.9315999746322632
topics[2].domain.id	https://openalex.org/domains/1
topics[2].domain.display_name	Life Sciences
topics[2].subfield.id	https://openalex.org/subfields/1305
topics[2].subfield.display_name	Biotechnology
topics[2].display_name	Cancer Research and Treatments
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C2781187634
concepts[0].level	4
concepts[0].score	0.6570342183113098
concepts[0].wikidata	https://www.wikidata.org/wiki/Q20969980
concepts[0].display_name	KRAS
concepts[1].id	https://openalex.org/C501734568
concepts[1].level	3
concepts[1].score	0.39551103115081787
concepts[1].wikidata	https://www.wikidata.org/wiki/Q42918
concepts[1].display_name	Mutation
concepts[2].id	https://openalex.org/C502942594
concepts[2].level	1
concepts[2].score	0.35399067401885986
concepts[2].wikidata	https://www.wikidata.org/wiki/Q3421914
concepts[2].display_name	Cancer research
concepts[3].id	https://openalex.org/C86803240
concepts[3].level	0
concepts[3].score	0.3167625367641449
concepts[3].wikidata	https://www.wikidata.org/wiki/Q420
concepts[3].display_name	Biology
concepts[4].id	https://openalex.org/C54355233
concepts[4].level	1
concepts[4].score	0.2740444839000702
concepts[4].wikidata	https://www.wikidata.org/wiki/Q7162
concepts[4].display_name	Genetics
concepts[5].id	https://openalex.org/C104317684
concepts[5].level	2
concepts[5].score	0.13424775004386902
concepts[5].wikidata	https://www.wikidata.org/wiki/Q7187
concepts[5].display_name	Gene
keywords[0].id	https://openalex.org/keywords/kras
keywords[0].score	0.6570342183113098
keywords[0].display_name	KRAS
keywords[1].id	https://openalex.org/keywords/mutation
keywords[1].score	0.39551103115081787
keywords[1].display_name	Mutation
keywords[2].id	https://openalex.org/keywords/cancer-research
keywords[2].score	0.35399067401885986
keywords[2].display_name	Cancer research
keywords[3].id	https://openalex.org/keywords/biology
keywords[3].score	0.3167625367641449
keywords[3].display_name	Biology
keywords[4].id	https://openalex.org/keywords/genetics
keywords[4].score	0.2740444839000702
keywords[4].display_name	Genetics
keywords[5].id	https://openalex.org/keywords/gene
keywords[5].score	0.13424775004386902
keywords[5].display_name	Gene
language	en
locations[0].id	doi:10.1158/1535-7163.22503655.v1
locations[0].is_oa	True
locations[0].source
locations[0].license	cc-by
locations[0].pdf_url
locations[0].version	acceptedVersion
locations[0].raw_type	posted-content
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	https://doi.org/10.1158/1535-7163.22503655.v1
locations[1].id	pmh:oai:figshare.com:article/22503655
locations[1].is_oa	True
locations[1].source.id	https://openalex.org/S4306400572
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	OPAL (Open@LaTrobe) (La Trobe University)
locations[1].source.host_organization	https://openalex.org/I196829312
locations[1].source.host_organization_name	La Trobe University
locations[1].source.host_organization_lineage	https://openalex.org/I196829312
locations[1].license	cc-by
locations[1].pdf_url
locations[1].version	submittedVersion
locations[1].raw_type
locations[1].license_id	https://openalex.org/licenses/cc-by
locations[1].is_accepted	False
locations[1].is_published	False
locations[1].raw_source_name
locations[1].landing_page_url	https://figshare.com/articles/journal_contribution/Supplementary_Material_and_Methods_from_i_IRS2_i_Copy_Number_Gain_i_KRAS_i_and_i_BRAF_i_Mutation_Status_as_Predictive_Biomarkers_for_Response_to_the_IGF-1R_IR_Inhibitor_BMS-754807_in_Colorectal_Cancer_Cell_Lines/22503655
indexed_in	crossref
authorships[0].author.id	https://openalex.org/A5100620486
authorships[0].author.orcid	https://orcid.org/0000-0001-9665-6642
authorships[0].author.display_name	Fei Huang
authorships[0].author_position	first
authorships[0].raw_author_name	Fei Huang
authorships[0].is_corresponding	False
authorships[1].author.id	https://openalex.org/A5106183263
authorships[1].author.orcid
authorships[1].author.display_name	Han Chang
authorships[1].author_position	middle
authorships[1].raw_author_name	Han Chang
authorships[1].is_corresponding	False
authorships[2].author.id	https://openalex.org/A5064430254
authorships[2].author.orcid	https://orcid.org/0000-0002-3625-4921
authorships[2].author.display_name	Ann Greer
authorships[2].author_position	middle
authorships[2].raw_author_name	Ann Greer
authorships[2].is_corresponding	False
authorships[3].author.id	https://openalex.org/A5074260221
authorships[3].author.orcid
authorships[3].author.display_name	Stephen Hillerman
authorships[3].author_position	middle
authorships[3].raw_author_name	Stephen Hillerman
authorships[3].is_corresponding	False
authorships[4].author.id	https://openalex.org/A5089007791
authorships[4].author.orcid
authorships[4].author.display_name	Karen A. Reeves
authorships[4].author_position	middle
authorships[4].raw_author_name	Karen A. Reeves
authorships[4].is_corresponding	False
authorships[5].author.id	https://openalex.org/A5005258847
authorships[5].author.orcid
authorships[5].author.display_name	Warren Hurlburt
authorships[5].author_position	middle
authorships[5].raw_author_name	Warren Hurlburt
authorships[5].is_corresponding	False
authorships[6].author.id	https://openalex.org/A5075325828
authorships[6].author.orcid
authorships[6].author.display_name	John Cogswell
authorships[6].author_position	middle
authorships[6].raw_author_name	John Cogswell
authorships[6].is_corresponding	False
authorships[7].author.id	https://openalex.org/A5057910121
authorships[7].author.orcid	https://orcid.org/0000-0002-8474-6453
authorships[7].author.display_name	Dharmesh Patel
authorships[7].author_position	middle
authorships[7].raw_author_name	Dharmesh Patel
authorships[7].is_corresponding	False
authorships[8].author.id	https://openalex.org/A5054751329
authorships[8].author.orcid
authorships[8].author.display_name	Zhenhao Qi
authorships[8].author_position	middle
authorships[8].raw_author_name	Zhenhao Qi
authorships[8].is_corresponding	False
authorships[9].author.id	https://openalex.org/A5111793100
authorships[9].author.orcid
authorships[9].author.display_name	Craig R. Fairchild
authorships[9].author_position	middle
authorships[9].raw_author_name	Craig Fairchild
authorships[9].is_corresponding	False
authorships[10].author.id	https://openalex.org/A5109566735
authorships[10].author.orcid
authorships[10].author.display_name	Rolf-Peter Ryseck
authorships[10].author_position	middle
authorships[10].raw_author_name	Rolf-Peter Ryseck
authorships[10].is_corresponding	False
authorships[11].author.id	https://openalex.org/A5104110277
authorships[11].author.orcid
authorships[11].author.display_name	Tai W. Wong
authorships[11].author_position	middle
authorships[11].raw_author_name	Tai W. Wong
authorships[11].is_corresponding	False
authorships[12].author.id	https://openalex.org/A5102825415
authorships[12].author.orcid	https://orcid.org/0009-0009-6251-6903
authorships[12].author.display_name	Friedrich Graf Finckenstein
authorships[12].author_position	middle
authorships[12].raw_author_name	Friedrich G. Finckenstein
authorships[12].is_corresponding	False
authorships[13].author.id	https://openalex.org/A5086284086
authorships[13].author.orcid	https://orcid.org/0000-0002-9820-5834
authorships[13].author.display_name	Jeffrey L. Jackson
authorships[13].author_position	middle
authorships[13].raw_author_name	Jeffrey Jackson
authorships[13].is_corresponding	False
authorships[14].author.id	https://openalex.org/A5088565265
authorships[14].author.orcid
authorships[14].author.display_name	Joan M. Carboni
authorships[14].author_position	last
authorships[14].raw_author_name	Joan M. Carboni
authorships[14].is_corresponding	False
has_content.pdf	False
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://doi.org/10.1158/1535-7163.22503655.v1
open_access.oa_status	gold
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Supplementary Material and Methods from <i>IRS2</i> Copy Number Gain, <i>KRAS</i> and <i>BRAF</i> Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T11067
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	0.97079998254776
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2730
primary_topic.subfield.display_name	Oncology
primary_topic.display_name	Colorectal Cancer Treatments and Studies
related_works	https://openalex.org/W3030972949, https://openalex.org/W2082860237, https://openalex.org/W4306404900, https://openalex.org/W4229832877, https://openalex.org/W3111812619, https://openalex.org/W4248366929, https://openalex.org/W2590035663, https://openalex.org/W1686926070, https://openalex.org/W4367603427, https://openalex.org/W3093086801
cited_by_count	0
locations_count	2
best_oa_location.id	doi:10.1158/1535-7163.22503655.v1
best_oa_location.is_oa	True
best_oa_location.source
best_oa_location.license	cc-by
best_oa_location.pdf_url
best_oa_location.version	acceptedVersion
best_oa_location.raw_type	posted-content
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	https://doi.org/10.1158/1535-7163.22503655.v1
primary_location.id	doi:10.1158/1535-7163.22503655.v1
primary_location.is_oa	True
primary_location.source
primary_location.license	cc-by
primary_location.pdf_url
primary_location.version	acceptedVersion
primary_location.raw_type	posted-content
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	https://doi.org/10.1158/1535-7163.22503655.v1
publication_date	2023-04-03
publication_year	2023
referenced_works_count	0
abstract_inverted_index.and	1
abstract_inverted_index.<p>Material	0
abstract_inverted_index.Methods</p>	2
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	15
sustainable_development_goals[0].id	https://metadata.un.org/sdg/3
sustainable_development_goals[0].score	0.47999998927116394
sustainable_development_goals[0].display_name	Good health and well-being
citation_normalized_percentile.value	0.31226927
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False

Supplementary Material and Methods from <i>IRS2</i> Copy Number Gain, <i>KRAS</i> and <i>BRAF</i> Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines Article Swipe

Related Topics

Raw OpenAlex JSON

Full payload