Supplementary Material for: Challenges and Opportunities for Cancer Predisposition Cascade Screening for Hereditary Breast and Ovarian Cancer and Lynch Syndrome in Switzerland: Findings from an International Workshop Article Swipe

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Christos Nikolaidis , Chang Ming , Carla Pedrazzani , Team Members Kimberly Vanderhorst , Andrea Kaiser-Grolimund , Zanfina Ademi , Rosmarie Bührer-Landolt , Nicole Bürki , Maria Caiata Zufferey , Victoria L. Champion , Pierre O. Chappuis , Christhardt Köhler , Tobias E. Erlanger , Rossella Graffeo , Heather Hampel , Karl Heinimann , Viola Heinzelmann‐Schwarz , Christian Kurzeder , Christian Monnerat , Laurel Northouse , Olivia Pagani , Nicole Probst‐Hensch , Manuela Rabaglio , Eckhard Schöenau , Sijbrands E.J.G. , Monica Taborelli , Corinne Urech , Valeria Viassolo , Simon Wieser , Maria C. Katapodi , For The CASCADE Consortium ·

YOU? · · 2019 · Open Access · · DOI: https://doi.org/10.6084/m9.figshare.7642241

Background: An international workshop on cancer predisposition cascade genetic screening for hereditary breast and ovarian cancer (HBOC) and Lynch syndrome (LS) took place in Switzerland, with leading researchers and clinicians in cascade screening and hereditary cancer from different disciplines. The purpose of the workshop was to enhance the implementation of cascade genetic screening in Switzerland. Participants discussed the challenges and opportunities associated with cascade screening for HBOC and LS in Switzerland (CASCADE study); family implications and the need for family-based interventions; the need to evaluate the cost-effectiveness of cascade genetic screening; and interprofessional collaboration needed to lead this initiative. Methods: The workshop aims were achieved through exchange of data and experiences from successful cascade screening programs in the Netherlands, Australia, and the state of Ohio, USA; Swiss-based studies and scientific experience that support cancer cascade screening in Switzerland; programs of research in psychosocial oncology and family-based studies; data from previous cost-effectiveness analyses of cascade genetic screening in the Netherlands and in Australia; and organizational experience from a large interprofessional collaborative. Scientific presentations were recorded and discussions were synthesized to present the workshop findings. Results: The key elements of successful implementation of cascade genetic screening are a supportive network of stakeholders and connection to complementary initiatives; sample size and recruitment of relatives; centralized organization of services; data-based cost-effectiveness analyses; transparent organization of the initiative; and continuous funding. Conclusions: This paper describes the processes and key findings of an international workshop on cancer predisposition cascade screening, which will guide the CASCADE study in Switzerland.

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Concepts

Lynch syndrome Ovarian cancer Cancer Medicine Breast cancer Oncology Gynecology Internal medicine Colorectal cancer DNA mismatch repair

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Type: dataset
Language: en
Landing Page: https://doi.org/10.6084/m9.figshare.7642241
OA Status: gold
Related Works: 10
OpenAlex ID: https://openalex.org/W4394321615

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DOI: https://doi.org/10.6084/m9.figshare.7642241

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Title: Supplementary Material for: Challenges and Opportunities for Cancer Predisposition Cascade Screening for Hereditary Breast and Ovarian Cancer and Lynch Syndrome in Switzerland: Findings from an International Workshop

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Language: en

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Publication year: 2019

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Publication date: 2019-01-01

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Authors: Christos Nikolaidis, Chang Ming, Carla Pedrazzani, Team Members Kimberly Vanderhorst, Andrea Kaiser-Grolimund, Zanfina Ademi, Rosmarie Bührer-Landolt, Nicole Bürki, Maria Caiata Zufferey, Victoria L. Champion, Pierre O. Chappuis, Christhardt Köhler, Tobias E. Erlanger, Rossella Graffeo, Heather Hampel, Karl Heinimann, Viola Heinzelmann‐Schwarz, Christian Kurzeder, Christian Monnerat, Laurel Northouse, Olivia Pagani, Nicole Probst‐Hensch, Manuela Rabaglio, Eckhard Schöenau, Sijbrands E.J.G., Monica Taborelli, Corinne Urech, Valeria Viassolo, Simon Wieser, Maria C. Katapodi, For The CASCADE Consortium

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Landing page: https://doi.org/10.6084/m9.figshare.7642241

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Concepts: Lynch syndrome, Ovarian cancer, Cancer, Medicine, Breast cancer, Oncology, Gynecology, Internal medicine, Colorectal cancer, DNA mismatch repair

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Cited by: 0

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Related works (count): 10

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abstract_inverted_index.USA;	125
abstract_inverted_index.aims	102
abstract_inverted_index.data	108, 147
abstract_inverted_index.from	36, 111, 148, 165
abstract_inverted_index.lead	96
abstract_inverted_index.need	77, 82
abstract_inverted_index.size	206
abstract_inverted_index.that	131
abstract_inverted_index.this	97
abstract_inverted_index.took	21
abstract_inverted_index.were	103, 172, 176
abstract_inverted_index.will	245
abstract_inverted_index.with	25, 62
abstract_inverted_index.Lynch	18
abstract_inverted_index.Ohio,	124
abstract_inverted_index.guide	246
abstract_inverted_index.large	167
abstract_inverted_index.paper	228
abstract_inverted_index.place	22
abstract_inverted_index.state	122
abstract_inverted_index.study	249
abstract_inverted_index.which	244
abstract_inverted_index.(HBOC)	16
abstract_inverted_index.breast	12
abstract_inverted_index.cancer	5, 15, 35, 133, 240
abstract_inverted_index.family	73
abstract_inverted_index.needed	94
abstract_inverted_index.sample	205
abstract_inverted_index.CASCADE	248
abstract_inverted_index.cascade	7, 31, 50, 63, 88, 113, 134, 153, 191, 242
abstract_inverted_index.enhance	46
abstract_inverted_index.genetic	8, 51, 89, 154, 192
abstract_inverted_index.leading	26
abstract_inverted_index.network	197
abstract_inverted_index.ovarian	14
abstract_inverted_index.present	179
abstract_inverted_index.purpose	40
abstract_inverted_index.studies	127
abstract_inverted_index.study);	72
abstract_inverted_index.support	132
abstract_inverted_index.through	105
abstract_inverted_index.(CASCADE	71
abstract_inverted_index.achieved	104
abstract_inverted_index.analyses	151
abstract_inverted_index.elements	186
abstract_inverted_index.evaluate	84
abstract_inverted_index.exchange	106
abstract_inverted_index.findings	234
abstract_inverted_index.funding.	225
abstract_inverted_index.oncology	143
abstract_inverted_index.previous	149
abstract_inverted_index.programs	115, 138
abstract_inverted_index.recorded	173
abstract_inverted_index.research	140
abstract_inverted_index.studies;	146
abstract_inverted_index.syndrome	19
abstract_inverted_index.workshop	3, 43, 101, 181, 238
abstract_inverted_index.analyses;	217
abstract_inverted_index.describes	229
abstract_inverted_index.different	37
abstract_inverted_index.discussed	56
abstract_inverted_index.findings.	182
abstract_inverted_index.processes	231
abstract_inverted_index.screening	9, 32, 52, 64, 114, 135, 155, 193
abstract_inverted_index.services;	214
abstract_inverted_index.Australia,	119
abstract_inverted_index.Australia;	161
abstract_inverted_index.Scientific	170
abstract_inverted_index.associated	61
abstract_inverted_index.challenges	58
abstract_inverted_index.clinicians	29
abstract_inverted_index.connection	201
abstract_inverted_index.continuous	224
abstract_inverted_index.data-based	215
abstract_inverted_index.experience	130, 164
abstract_inverted_index.hereditary	11, 34
abstract_inverted_index.relatives;	210
abstract_inverted_index.scientific	129
abstract_inverted_index.screening,	243
abstract_inverted_index.screening;	90
abstract_inverted_index.successful	112, 188
abstract_inverted_index.supportive	196
abstract_inverted_index.Netherlands	158
abstract_inverted_index.Swiss-based	126
abstract_inverted_index.Switzerland	70
abstract_inverted_index.centralized	211
abstract_inverted_index.discussions	175
abstract_inverted_index.experiences	110
abstract_inverted_index.initiative.	98
abstract_inverted_index.initiative;	222
abstract_inverted_index.recruitment	208
abstract_inverted_index.researchers	27
abstract_inverted_index.synthesized	177
abstract_inverted_index.transparent	218
abstract_inverted_index.Netherlands,	118
abstract_inverted_index.Participants	55
abstract_inverted_index.Switzerland,	24
abstract_inverted_index.Switzerland.	54, 251
abstract_inverted_index.Switzerland;	137
abstract_inverted_index.disciplines.	38
abstract_inverted_index.family-based	79, 145
abstract_inverted_index.implications	74
abstract_inverted_index.initiatives;	204
abstract_inverted_index.organization	212, 219
abstract_inverted_index.psychosocial	142
abstract_inverted_index.stakeholders	199
abstract_inverted_index.collaboration	93
abstract_inverted_index.complementary	203
abstract_inverted_index.international	2, 237
abstract_inverted_index.opportunities	60
abstract_inverted_index.presentations	171
abstract_inverted_index.collaborative.	169
abstract_inverted_index.implementation	48, 189
abstract_inverted_index.interventions;	80
abstract_inverted_index.organizational	163
abstract_inverted_index.predisposition	6, 241
abstract_inverted_index.interprofessional	92, 168
abstract_inverted_index.cost-effectiveness	86, 150, 216
abstract_inverted_index.<b><i>Methods:</i></b>	99
abstract_inverted_index.<b><i>Results:</i></b>	183
abstract_inverted_index.<b><i>Background:</i></b>	0
abstract_inverted_index.<b><i>Conclusions:</i></b>	226
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	31
citation_normalized_percentile