Supplementary Material for: Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation in Mice and Humans Article Swipe

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Gurneet S. Sangha , Albert Busch , Andrea Acuna , Alycia G. Berman , Edward H Phillips , Matthias Trenner , Hans‐Henning Eckstein , Lars Mäegdefessel , Craig J. Goergen ·

YOU? · · 2019 · Open Access · · DOI: https://doi.org/10.6084/m9.figshare.8668124

Reduced lower-limb blood flow has been shown to lead to asymmetrical abdominal aortic aneurysms (AAAs) but the mechanism of action is not fully understood. Therefore, small animal ultrasound (Vevo2100, FUJIFILM VisualSonics) was used to longitudinally study mice that underwent standard porcine pancreatic elastase (PPE) infusion (n = 5), and PPE infusion with modified 20% iliac artery stenosis in the left (n = 4) and right (n = 5) iliac arteries. Human AAA computed tomography images were obtained from patients with normal (n = 9) or stenosed left (n = 2), right (n = 1), and bilateral (n = 1) iliac arteries. We observed rapid early growth and rightward expansion (8/9 mice) in the modified PPE groups (p < 0.05), leading to slightly larger and asymmetric AAAs compared to the standard PPE group. Further examination showed a significant increase in TGFβ1 (p < 0.05) and cellular infiltration (p < 0.05) in the modified PPE group versus standard PPE mice. Congruent, yet variable, observations were made in human AAA patients with reduced iliac outflow compared to those with normal iliac outflow. Our results suggest that arterial stenosis at the time of aneurysm induction leads to faster AAA growth with aneurysm asymmetry and increased vascular inflammation after 8 weeks, indicating that moderate iliac stenosis may have upstream effects on AAA progression.

Related Topics

Abdominal Aortic Aneurysm

Concepts

Abdominal aortic aneurysm Stenosis Medicine Cardiology Aortic aneurysm Internal medicine Aneurysm Radiology

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Type: dataset
Language: en
Landing Page: https://doi.org/10.6084/m9.figshare.8668124
OA Status: gold
Related Works: 10
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DOI: https://doi.org/10.6084/m9.figshare.8668124

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Title: Supplementary Material for: Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation in Mice and Humans

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Type: dataset

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Language: en

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Publication year: 2019

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Publication date: 2019-01-01

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Authors: Gurneet S. Sangha, Albert Busch, Andrea Acuna, Alycia G. Berman, Edward H Phillips, Matthias Trenner, Hans‐Henning Eckstein, Lars Mäegdefessel, Craig J. Goergen

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Landing page: https://doi.org/10.6084/m9.figshare.8668124

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OA status: gold

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OA URL: https://doi.org/10.6084/m9.figshare.8668124

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Concepts: Abdominal aortic aneurysm, Stenosis, Medicine, Cardiology, Aortic aneurysm, Internal medicine, Aneurysm, Radiology

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Cited by: 0

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Related works (count): 10

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