Supplementary Material for: Maternal Style Selectively Shapes Amygdalar Development and Social Behavior in Rats Genetically Prone to High Anxiety Article Swipe
Joshua L. Cohen
,
Matthew E. Glover
,
Phyllis C. Pugh
,
A.D. Fant
,
Rebecca K. Simmons
,
Huda Akil
,
Ilan A. Kerman
,
Sarah M. Clinton
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.6084/m9.figshare.5127628
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.6084/m9.figshare.5127628
The early-life environment critically influences neurodevelopment and later psychological health. To elucidate neural and environmental elements that shape emotional behavior, we developed a rat model of individual differences in temperament and environmental reactivity. We selectively bred rats for high versus low behavioral response to novelty and found that high-reactive (bred high-responder, bHR) rats displayed greater risk-taking, impulsivity and aggression relative to low-reactive (bred low-responder, bLR) rats, which showed high levels of anxiety/depression-like behavior and certain stress vulnerability. The bHR/bLR traits are heritable, but prior work revealed bHR/bLR maternal style differences, with bLR dams showing more maternal attention than bHRs. The present study implemented a cross-fostering paradigm to examine the contribution of maternal behavior to the brain development and emotional behavior of bLR offspring. bLR offspring were reared by biological bLR mothers or fostered to a bLR or bHR mother and then evaluated to determine the effects on the following: (1) developmental gene expression in the hippocampus and amygdala and (2) adult anxiety/depression-like behavior. Genome-wide expression profiling showed that cross-fostering bLR rats to bHR mothers shifted developmental gene expression in the amygdala (but not hippocampus), reduced adult anxiety and enhanced social interaction. Our findings illustrate how an early-life manipulation such as cross-fostering changes the brain's developmental trajectory and ultimately impacts adult behavior. Moreover, while earlier studies highlighted hippocampal differences contributing to the bHR/bLR phenotypes, our results point to a role of the amygdala as well. Future work will pursue genetic and cellular mechanisms within the amygdala that contribute to bHR/bLR behavior either at baseline or following environmental manipulations.
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https://openalex.org/W4394527499Canonical identifier for this work in OpenAlex
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https://doi.org/10.6084/m9.figshare.5127628Digital Object Identifier
- Title
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Supplementary Material for: Maternal Style Selectively Shapes Amygdalar Development and Social Behavior in Rats Genetically Prone to High AnxietyWork title
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datasetOpenAlex work type
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enPrimary language
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2015Year of publication
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2015-01-01Full publication date if available
- Authors
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Joshua L. Cohen, Matthew E. Glover, Phyllis C. Pugh, A.D. Fant, Rebecca K. Simmons, Huda Akil, Ilan A. Kerman, Sarah M. ClintonList of authors in order
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https://doi.org/10.6084/m9.figshare.5127628Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.6084/m9.figshare.5127628Direct OA link when available
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Anxiety, Style (visual arts), Psychology, Social anxiety, Amygdala, Developmental psychology, Neuroscience, Geography, Psychiatry, ArchaeologyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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