Supplementary Methods from Combined Administration of Rituximab and ON 013105 Induces Apoptosis in Mantle Cell Lymphoma Cells and Reduces Tumor Burden in a Mouse Model of Mantle Cell Lymphoma Article Swipe

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Mantle cell lymphoma Chemistry Lymphoma Antibody Cancer research Monoclonal antibody Titration Molecular biology Apoptosis Biochemistry Biology Immunology Physical chemistry

Anil Prasad , Ashutosh Shrivastava , Evangelos Papadopoulos , Paula M. Kuzontkoski , M.V. Ramana Reddy , Amanda M. Gillum , Ramesh Kumar , E. Premkumar Reddy , Jerome E. Groopman ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/1078-0432.22449836.v1 · OA: W4361968885

<p>PDF file - 100K, Supplementary Methods including: cells, antibodies, preparation of GST-eIF4E and GB1-eIF4E proteins, assessing protein/compound binding by saturation transfer difference (STD) and 1D 1H-NMR spectra, assessing protein/compound binding with protein titration and 1D 1H-NMR spectra, fluorescence intensity quenching, pharmacokinetic analysis and routes of ON 013105 administration.</p>