Suppression of Fear Memory Reinstatement by 3,6′-Disinapoyl Sucrose Article Swipe
Ga-eul Han
,
Ji Hye Yoon
,
Heon-Ho Song
,
Young-Joo Hong
,
Jihyun Youm
,
Yong-Hee Ha
,
Min-jeong Jeong
,
JeaHyun Lee
,
Sung Ho Lim
,
Ji-Hwan Shin
,
Sungho Maeng
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-7737464/v1
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-7737464/v1
Fear memories are easily formed but very difficult to erase, and even after extinction, they easily relapse. Post-traumatic stress disorder(PTSD) is a disorder characterized by persistent and excessive symptoms triggered by traumatic fear memories. Treatment to erase these memories is time-consuming and prone to relapse. Radix polygalae has been shown to inhibit the reinstatement and renewal of fear memories in mice. This study aimed to identify components of Radix polygalae and its optimal dose that suppresses fear reinstatement using the fear conditioning paradigm in animal models and measure the cognitive and anxiety related behaviors and molecular changes in the hippocampus. Among senegenin, TMCA, and DISS, only DISS inhibited reinstatement, and the optimal dose was 1 mg/kg. In normal mice, this dose had no effect on spatial memory or working memory, but an anxiolytic effects. Furthermore, it increased the expression of p-CREB and glucocorticoid receptors in the hippocampus. These results suggest that DISS selectively inhibits the reinstatement of fear memory without affecting other cognitive functions, and that this effect is related to its action on neurotrophic and stress-response pathways in the hippocampus. DISS will possibly be used to suppress fear memory recurrence in PTSD patients at appropriate doses.
Related Topics
Concepts
Anxiety
Cognition
Anxiolytic
Fear conditioning
Psychology
Neuroscience
Extinction (optical mineralogy)
Phobias
Anxiety disorder
Medicine
Freezing behavior
Hippocampus
Antagonist
Animal model
Action (physics)
Effects of stress on memory
Impaired memory
Fear processing in the brain
Memory impairment
Receptor
Recall
Animal studies
Metadata
- Type
- article
- Landing Page
- https://doi.org/10.21203/rs.3.rs-7737464/v1
- https://www.researchsquare.com/article/rs-7737464/latest.pdf
- OA Status
- gold
- References
- 30
- OpenAlex ID
- https://openalex.org/W7105895267
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W7105895267Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-7737464/v1Digital Object Identifier
- Title
-
Suppression of Fear Memory Reinstatement by 3,6′-Disinapoyl SucroseWork title
- Type
-
articleOpenAlex work type
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-18Full publication date if available
- Authors
-
Ga-eul Han, Ji Hye Yoon, Heon-Ho Song, Young-Joo Hong, Jihyun Youm, Yong-Hee Ha, Min-jeong Jeong, JeaHyun Lee, Sung Ho Lim, Ji-Hwan Shin, Sungho MaengList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-7737464/v1Publisher landing page
- PDF URL
-
https://www.researchsquare.com/article/rs-7737464/latest.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-7737464/latest.pdfDirect OA link when available
- Concepts
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Anxiety, Cognition, Anxiolytic, Fear conditioning, Psychology, Neuroscience, Extinction (optical mineralogy), Phobias, Anxiety disorder, Medicine, Freezing behavior, Hippocampus, Antagonist, Animal model, Action (physics), Effects of stress on memory, Impaired memory, Fear processing in the brain, Memory impairment, Receptor, Recall, Animal studiesTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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30Number of works referenced by this work
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