Cell Reports • Vol 12 • No 1
Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma
June 2015 • Edward L. LaGory, Colleen Wu, Cullen M. Taniguchi, Chien‐Kuang Cornelia Ding, Jen‐Tsan Chi, Rie von Eyben, David A. Scott, Adam Richardson, Amato J. …
Long believed to be a byproduct of malignant transformation, reprogramming of cellular metabolism is now recognized as a driving force in tumorigenesis. In clear cell renal cell carcinoma (ccRCC), frequent activation of HIF signaling induces a metabolic switch that promotes tumorigenesis. Here, we demonstrate that PGC-1α, a central regulator of energy metabolism, is suppressed in VHL-deficient ccRCC by a HIF/Dec1-dependent mechanism. In VHL wild-type cells, PGC-1α suppression leads to decreased expression of the m…