Surgical Management of the Axilla in Clinically Node-Positive Breast Cancer Patients Converting to Clinical Node Negativity through Neoadjuvant Chemotherapy: Current Status, Knowledge Gaps, and Rationale for the EUBREAST-03 AXSANA Study Article Swipe
YOU?
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· 2021
· Open Access
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· DOI: https://doi.org/10.3390/cancers13071565
In the last two decades, surgical methods for axillary staging in breast cancer patients have become less extensive, and full axillary lymph node dissection (ALND) is confined to selected patients. In initially node-positive patients undergoing neoadjuvant chemotherapy, however, the optimal management remains unclear. Current guidelines vary widely, endorsing different strategies. We performed a literature review on axillary staging strategies and their place in international recommendations. This overview defines knowledge gaps associated with specific procedures, summarizes currently ongoing clinical trials that address these unsolved issues, and provides the rationale for further research. While some guidelines have already implemented surgical de-escalation, replacing ALND with, e.g., sentinel lymph node biopsy (SLNB) or targeted axillary dissection (TAD) in cN+ patients converting to clinical node negativity, others recommend ALND. Numerous techniques are in use for tagging lymph node metastasis, but many questions regarding the marking technique, i.e., the optimal time for marker placement and the number of marked nodes, remain unanswered. The optimal number of SLNs to be excised also remains a matter of debate. Data on oncological safety and quality of life following different staging procedures are lacking. These results provide the rationale for the multinational prospective cohort study AXSANA initiated by EUBREAST, which started enrollment in June 2020 and aims at recruiting 3000 patients in 20 countries (NCT04373655; Funded by AGO-B, Claudia von Schilling Foundation for Breast Cancer Research, AWOgyn, EndoMag, Mammotome, and MeritMedical).
Related Topics
- Type
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- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers13071565
- https://www.mdpi.com/2072-6694/13/7/1565/pdf?version=1617937761
- OA Status
- gold
- Cited By
- 138
- References
- 55
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3150705348
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3150705348Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/cancers13071565Digital Object Identifier
- Title
-
Surgical Management of the Axilla in Clinically Node-Positive Breast Cancer Patients Converting to Clinical Node Negativity through Neoadjuvant Chemotherapy: Current Status, Knowledge Gaps, and Rationale for the EUBREAST-03 AXSANA StudyWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-03-29Full publication date if available
- Authors
-
Maggie Banys‐Paluchowski, Maria Luisa Gasparri, Jana de Boniface, Oreste Gentilini, Elmar Stickeler, Steffi Hartmann, Marc Thill, Isabel T. Rubio, Rosa Di Micco, Eduard-Alexandru Bonci, Laura Niinikoski, Michalis Kontos, Güldeniz Karadeniz Çakmak, Michael Hauptmann, Florentia Peintinger, David Pinto, Zoltán Mátrai, Dawid Murawa, Geeta Kadayaprath, Lukáš Dostálek, Helidon Nina, Petr Krivorotko, Jean‐Marc Classe, Ellen Schlichting, Matilda Appelgren, Peter Paluchowski, Christine Solbach, Jens‐Uwe Blohmer, Thorsten KühnList of authors in order
- Landing page
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https://doi.org/10.3390/cancers13071565Publisher landing page
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https://www.mdpi.com/2072-6694/13/7/1565/pdf?version=1617937761Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2072-6694/13/7/1565/pdf?version=1617937761Direct OA link when available
- Concepts
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Medicine, Breast cancer, Axillary Lymph Node Dissection, Axilla, Sentinel lymph node, Sentinel node, Neoadjuvant therapy, General surgery, Surgery, Cancer, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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138Total citation count in OpenAlex
- Citations by year (recent)
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2025: 31, 2024: 26, 2023: 36, 2022: 34, 2021: 11Per-year citation counts (last 5 years)
- References (count)
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55Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.lacking. | 183 |
| abstract_inverted_index.overview | 66 |
| abstract_inverted_index.patients | 13, 33, 115, 210 |
| abstract_inverted_index.provides | 85 |
| abstract_inverted_index.selected | 28 |
| abstract_inverted_index.sentinel | 103 |
| abstract_inverted_index.specific | 72 |
| abstract_inverted_index.surgical | 5, 97 |
| abstract_inverted_index.targeted | 109 |
| abstract_inverted_index.unclear. | 42 |
| abstract_inverted_index.unsolved | 82 |
| abstract_inverted_index.EUBREAST, | 198 |
| abstract_inverted_index.Research, | 225 |
| abstract_inverted_index.Schilling | 220 |
| abstract_inverted_index.countries | 213 |
| abstract_inverted_index.currently | 75 |
| abstract_inverted_index.different | 48, 179 |
| abstract_inverted_index.endorsing | 47 |
| abstract_inverted_index.following | 178 |
| abstract_inverted_index.initially | 31 |
| abstract_inverted_index.initiated | 196 |
| abstract_inverted_index.knowledge | 68 |
| abstract_inverted_index.patients. | 29 |
| abstract_inverted_index.performed | 51 |
| abstract_inverted_index.placement | 147 |
| abstract_inverted_index.questions | 136 |
| abstract_inverted_index.rationale | 87, 188 |
| abstract_inverted_index.recommend | 122 |
| abstract_inverted_index.regarding | 137 |
| abstract_inverted_index.replacing | 99 |
| abstract_inverted_index.research. | 90 |
| abstract_inverted_index.Foundation | 221 |
| abstract_inverted_index.Mammotome, | 228 |
| abstract_inverted_index.associated | 70 |
| abstract_inverted_index.converting | 116 |
| abstract_inverted_index.dissection | 23, 111 |
| abstract_inverted_index.enrollment | 201 |
| abstract_inverted_index.extensive, | 17 |
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| abstract_inverted_index.literature | 53 |
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| abstract_inverted_index.procedures | 181 |
| abstract_inverted_index.recruiting | 208 |
| abstract_inverted_index.strategies | 58 |
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| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 99 |
| corresponding_author_ids | https://openalex.org/A5079805352 |
| countries_distinct_count | 18 |
| institutions_distinct_count | 29 |
| corresponding_institution_ids | https://openalex.org/I4210112713, https://openalex.org/I44260953, https://openalex.org/I9341345 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/17 |
| sustainable_development_goals[0].score | 0.46000000834465027 |
| sustainable_development_goals[0].display_name | Partnerships for the goals |
| citation_normalized_percentile.value | 0.99085858 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |