Surgical Timing in Patients With Infective Endocarditis and With Intracranial Hemorrhage: A Systematic Review and Meta‐Analysis Article Swipe
Rita Musleh
,
Peter Schlattmann
,
Túlio Caldonazo
,
Hristo Kirov
,
Otto W. Witte
,
Torsten Doenst
,
Albrecht Günther
,
Mahmoud Diab
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1161/jaha.121.024401
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1161/jaha.121.024401
Background Intracranial hemorrhage (ICH) is one of the main causes for lack of surgery in patients with infective endocarditis (IE), despite the presence of surgical indications. We aimed to evaluate the impact of early surgery in patients with IE and with ICH on postoperative neurological deterioration and all‐cause mortality and to elucidate the risk of 30‐day mortality in patients who were denied surgery. Methods and Results Three libraries (MEDLINE, EMBASE, and Cochrane Library) were assessed. The primary outcome was all‐cause mortality, and the secondary outcome was neurological deterioration. Inverse variance method and random model were performed. We identified 16 studies including 355 patients. Nine studies examined the impact of surgical timing (early versus late) and were included in the meta‐analysis. Only one study examined the fate of patients with IE and with ICH who were treated conservatively despite having an indication for cardiac surgery, showing higher mortality rates than those who underwent surgery (11.8% versus 2.5%). We found no significant association between early surgery, regardless of its definition, and a higher mortality (odds ratio [OR], 1.69; 95% CI, 0.95–3.02). Early surgery was associated with higher risk for neurological deterioration (OR, 2.00; 95% CI, 1.10–3.65). Conclusions Cardiac surgery for IE within 30 days of ICH was not associated with higher mortality, but with an increased rate of neurological deterioration. The 30‐day mortality in patients with IE and with ICH who were denied surgery has not yet been sufficiently investigated. This patient group should be analyzed in future studies in more detail.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1161/jaha.121.024401
- https://www.ahajournals.org/doi/pdf/10.1161/JAHA.121.024401
- OA Status
- gold
- Cited By
- 21
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4280516725
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4280516725Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1161/jaha.121.024401Digital Object Identifier
- Title
-
Surgical Timing in Patients With Infective Endocarditis and With Intracranial Hemorrhage: A Systematic Review and Meta‐AnalysisWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-05-16Full publication date if available
- Authors
-
Rita Musleh, Peter Schlattmann, Túlio Caldonazo, Hristo Kirov, Otto W. Witte, Torsten Doenst, Albrecht Günther, Mahmoud DiabList of authors in order
- Landing page
-
https://doi.org/10.1161/jaha.121.024401Publisher landing page
- PDF URL
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https://www.ahajournals.org/doi/pdf/10.1161/JAHA.121.024401Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.ahajournals.org/doi/pdf/10.1161/JAHA.121.024401Direct OA link when available
- Concepts
-
Medicine, Infective endocarditis, Odds ratio, Endocarditis, Cochrane Library, Surgery, Meta-analysis, Mortality rate, Cardiac surgery, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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21Total citation count in OpenAlex
- Citations by year (recent)
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2025: 6, 2024: 6, 2023: 8, 2022: 1Per-year citation counts (last 5 years)
- References (count)
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42Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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