Surviving the heat: heterogeneity of response in S accharomyces cerevisiae provides insight into thermal damage to the membrane
Article Swipe
Stéphane Guyot
,
Patrick Gervais
,
Michael Young
,
Pascale Winckler
,
Jennifer Dumont
,
Hazel M. Davey
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1111/1462-2920.12866
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1111/1462-2920.12866
Summary Environmental heat stress impacts on the physiology and viability of microbial cells with concomitant implications for microbial activity and diversity. Previously, it has been demonstrated that gradual heating of S accharomyces cerevisiae induces a degree of thermal resistance, whereas a heat shock results in a high level of cell death. Here, we show that the impact of exogenous nutrients on acquisition of thermal resistance differs between strains. Using single‐cell methods, we demonstrate the extent of heterogeneity of the heat‐stress response within populations of yeast cells and the presence of subpopulations that are reversibly damaged by heat stress. Such cells represent potential for recovery of entire populations once stresses are removed. The results show that plasma membrane permeability and potential are key factors involved in cell survival, but thermal resistance is not related to homeoviscous adaptation of the plasma membrane. These results have implications for growth and regrowth of populations experiencing environmental heat stress and our understanding of impacts at the level of the single cell. Given the important role of microbes in biofuel production and bioremediation, a thorough understanding of the impact of stress responses of populations and individuals is highly desirable.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/1462-2920.12866
- https://www.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1462-2920.12866
- OA Status
- hybrid
- Cited By
- 56
- References
- 56
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W1524635337
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- OpenAlex ID
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https://openalex.org/W1524635337Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/1462-2920.12866Digital Object Identifier
- Title
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Surviving the heat: heterogeneity of response in
S accharomyces cerevisiae provides insight into thermal damage to the membraneWork title - Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2015Year of publication
- Publication date
-
2015-04-03Full publication date if available
- Authors
-
Stéphane Guyot, Patrick Gervais, Michael Young, Pascale Winckler, Jennifer Dumont, Hazel M. DaveyList of authors in order
- Landing page
-
https://doi.org/10.1111/1462-2920.12866Publisher landing page
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https://www.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1462-2920.12866Direct link to full text PDF
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YesWhether a free full text is available
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-
hybridOpen access status per OpenAlex
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https://www.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1462-2920.12866Direct OA link when available
- Concepts
-
Biology, Yeast, Saccharomyces cerevisiae, Thermal shock, Heat shock protein, Cell biology, Adaptation (eye), Membrane permeability, Heat shock, Cell, Heat stress, Membrane, Biophysics, Biochemistry, Materials science, Gene, Animal science, Composite material, NeuroscienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
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56Total citation count in OpenAlex
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2025: 8, 2024: 5, 2023: 4, 2022: 4, 2021: 3Per-year citation counts (last 5 years)
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56Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.single‐cell | 69 |
| abstract_inverted_index.understanding | 156, 179 |
| abstract_inverted_index.subpopulations | 90 |
| abstract_inverted_index.bioremediation, | 176 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 94 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 6 |
| citation_normalized_percentile.value | 0.90518356 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |