Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice Article Swipe

PDF

Emily M. Rocha , Gaynor A. Smith , Eric Park , Hongmei Cao , Anne-Renee Graham , Eilish Brown , Jesse R. McLean , Melissa A. Hayes , Jonathan A. Beagan , Sarah C. Izen , Eduardo Pérez-Torres , Penelope J. Hallett , Ole Isacson ·

YOU? · · 2015 · Open Access · · DOI: https://doi.org/10.1089/ars.2015.6307

These data reveal a link between reduced glucocerebrosidase and the development of α-synucleinopathy and pathophysiological abnormalities in mice, and support the development of GCase therapeutics to reduce α-synucleinopathy in PD and related disorders.

Related Topics

Concepts

Glucocerebrosidase Synucleinopathies Neurodegeneration Neuroinflammation Autophagy Substantia nigra Alpha-synuclein Microglia Parkinson's disease Cell biology Biology Chemistry Neuroscience Biochemistry Immunology Inflammation Medicine Pathology Enzyme Dopaminergic Disease Dopamine Apoptosis

Metadata

Type: article
Language: en
Landing Page: https://doi.org/10.1089/ars.2015.6307
PDF: https://www.liebertpub.com/doi/pdf/10.1089/ars.2015.6307
OA Status: hybrid
Cited By: 144
References: 70
Related Works: 10
OpenAlex ID: https://openalex.org/W1913190924

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W1913190924

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1089/ars.2015.6307

Digital Object Identifier
Title: Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice

Work title
Type: article

OpenAlex work type
Language: en

Primary language
Publication year: 2015

Year of publication
Publication date: 2015-06-21

Full publication date if available
Authors: Emily M. Rocha, Gaynor A. Smith, Eric Park, Hongmei Cao, Anne-Renee Graham, Eilish Brown, Jesse R. McLean, Melissa A. Hayes, Jonathan A. Beagan, Sarah C. Izen, Eduardo Pérez-Torres, Penelope J. Hallett, Ole Isacson

List of authors in order
Landing page: https://doi.org/10.1089/ars.2015.6307

Publisher landing page
PDF URL: https://www.liebertpub.com/doi/pdf/10.1089/ars.2015.6307

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: hybrid

Open access status per OpenAlex
OA URL: https://www.liebertpub.com/doi/pdf/10.1089/ars.2015.6307

Direct OA link when available
Concepts: Glucocerebrosidase, Synucleinopathies, Neurodegeneration, Neuroinflammation, Autophagy, Substantia nigra, Alpha-synuclein, Microglia, Parkinson's disease, Cell biology, Biology, Chemistry, Neuroscience, Biochemistry, Immunology, Inflammation, Medicine, Pathology, Enzyme, Dopaminergic, Disease, Dopamine, Apoptosis

Top concepts (fields/topics) attached by OpenAlex
Cited by: 144

Total citation count in OpenAlex
Citations by year (recent): 2025: 11, 2024: 18, 2023: 16, 2022: 21, 2021: 19

Per-year citation counts (last 5 years)
References (count): 70

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W1913190924
doi	https://doi.org/10.1089/ars.2015.6307
ids.doi	https://doi.org/10.1089/ars.2015.6307
ids.mag	1913190924
ids.pmid	https://pubmed.ncbi.nlm.nih.gov/26094487
ids.openalex	https://openalex.org/W1913190924
fwci	5.41356646
mesh[0].qualifier_ui
mesh[0].descriptor_ui	D000818
mesh[0].is_major_topic	False
mesh[0].qualifier_name
mesh[0].descriptor_name	Animals
mesh[1].qualifier_ui
mesh[1].descriptor_ui	D001343
mesh[1].is_major_topic	False
mesh[1].qualifier_name
mesh[1].descriptor_name	Autophagy
mesh[2].qualifier_ui
mesh[2].descriptor_ui	D001370
mesh[2].is_major_topic	False
mesh[2].qualifier_name
mesh[2].descriptor_name	Axonal Transport
mesh[3].qualifier_ui	Q000378
mesh[3].descriptor_ui	D002540
mesh[3].is_major_topic	False
mesh[3].qualifier_name	metabolism
mesh[3].descriptor_name	Cerebral Cortex
mesh[4].qualifier_ui	Q000473
mesh[4].descriptor_ui	D002540
mesh[4].is_major_topic	False
mesh[4].qualifier_name	pathology
mesh[4].descriptor_name	Cerebral Cortex
mesh[5].qualifier_ui
mesh[5].descriptor_ui	D003167
mesh[5].is_major_topic	False
mesh[5].qualifier_name
mesh[5].descriptor_name	Complement Activation
mesh[6].qualifier_ui	Q000378
mesh[6].descriptor_ui	D015922
mesh[6].is_major_topic	False
mesh[6].qualifier_name	metabolism
mesh[6].descriptor_name	Complement C1q
mesh[7].qualifier_ui	Q000037
mesh[7].descriptor_ui	D005962
mesh[7].is_major_topic	False
mesh[7].qualifier_name	antagonists & inhibitors
mesh[7].descriptor_name	Glucosylceramidase
mesh[8].qualifier_ui	Q000378
mesh[8].descriptor_ui	D005962
mesh[8].is_major_topic	False
mesh[8].qualifier_name	metabolism
mesh[8].descriptor_name	Glucosylceramidase
mesh[9].qualifier_ui	Q000031
mesh[9].descriptor_ui	D007294
mesh[9].is_major_topic	False
mesh[9].qualifier_name	analogs & derivatives
mesh[9].descriptor_name	Inositol
mesh[10].qualifier_ui	Q000494
mesh[10].descriptor_ui	D007294
mesh[10].is_major_topic	False
mesh[10].qualifier_name	pharmacology
mesh[10].descriptor_name	Inositol
mesh[11].qualifier_ui
mesh[11].descriptor_ui	D008297
mesh[11].is_major_topic	False
mesh[11].qualifier_name
mesh[11].descriptor_name	Male
mesh[12].qualifier_ui
mesh[12].descriptor_ui	D051379
mesh[12].is_major_topic	False
mesh[12].qualifier_name
mesh[12].descriptor_name	Mice
mesh[13].qualifier_ui	Q000502
mesh[13].descriptor_ui	D017628
mesh[13].is_major_topic	False
mesh[13].qualifier_name	physiology
mesh[13].descriptor_name	Microglia
mesh[14].qualifier_ui	Q000139
mesh[14].descriptor_ui	D010302
mesh[14].is_major_topic	False
mesh[14].qualifier_name	chemically induced
mesh[14].descriptor_name	Parkinson Disease, Secondary
mesh[15].qualifier_ui	Q000201
mesh[15].descriptor_ui	D010302
mesh[15].is_major_topic	False
mesh[15].qualifier_name	enzymology
mesh[15].descriptor_name	Parkinson Disease, Secondary
mesh[16].qualifier_ui	Q000139
mesh[16].descriptor_ui	D066263
mesh[16].is_major_topic	False
mesh[16].qualifier_name	chemically induced
mesh[16].descriptor_name	Protein Aggregation, Pathological
mesh[17].qualifier_ui	Q000201
mesh[17].descriptor_ui	D066263
mesh[17].is_major_topic	False
mesh[17].qualifier_name	enzymology
mesh[17].descriptor_name	Protein Aggregation, Pathological
mesh[18].qualifier_ui	Q000378
mesh[18].descriptor_ui	D011506
mesh[18].is_major_topic	False
mesh[18].qualifier_name	metabolism
mesh[18].descriptor_name	Proteins
mesh[19].qualifier_ui
mesh[19].descriptor_ui	D009435
mesh[19].is_major_topic	False
mesh[19].qualifier_name
mesh[19].descriptor_name	Synaptic Transmission
mesh[20].qualifier_ui	Q000378
mesh[20].descriptor_ui	D051844
mesh[20].is_major_topic	False
mesh[20].qualifier_name	metabolism
mesh[20].descriptor_name	alpha-Synuclein
mesh[21].qualifier_ui
mesh[21].descriptor_ui	D000818
mesh[21].is_major_topic	False
mesh[21].qualifier_name
mesh[21].descriptor_name	Animals
mesh[22].qualifier_ui
mesh[22].descriptor_ui	D001343
mesh[22].is_major_topic	False
mesh[22].qualifier_name
mesh[22].descriptor_name	Autophagy
mesh[23].qualifier_ui
mesh[23].descriptor_ui	D001370
mesh[23].is_major_topic	False
mesh[23].qualifier_name
mesh[23].descriptor_name	Axonal Transport
mesh[24].qualifier_ui	Q000378
mesh[24].descriptor_ui	D002540
mesh[24].is_major_topic	False
mesh[24].qualifier_name	metabolism
mesh[24].descriptor_name	Cerebral Cortex
mesh[25].qualifier_ui	Q000473
mesh[25].descriptor_ui	D002540
mesh[25].is_major_topic	False
mesh[25].qualifier_name	pathology
mesh[25].descriptor_name	Cerebral Cortex
mesh[26].qualifier_ui
mesh[26].descriptor_ui	D003167
mesh[26].is_major_topic	False
mesh[26].qualifier_name
mesh[26].descriptor_name	Complement Activation
mesh[27].qualifier_ui	Q000378
mesh[27].descriptor_ui	D015922
mesh[27].is_major_topic	False
mesh[27].qualifier_name	metabolism
mesh[27].descriptor_name	Complement C1q
mesh[28].qualifier_ui	Q000037
mesh[28].descriptor_ui	D005962
mesh[28].is_major_topic	False
mesh[28].qualifier_name	antagonists & inhibitors
mesh[28].descriptor_name	Glucosylceramidase
mesh[29].qualifier_ui	Q000378
mesh[29].descriptor_ui	D005962
mesh[29].is_major_topic	False
mesh[29].qualifier_name	metabolism
mesh[29].descriptor_name	Glucosylceramidase
mesh[30].qualifier_ui	Q000031
mesh[30].descriptor_ui	D007294
mesh[30].is_major_topic	False
mesh[30].qualifier_name	analogs & derivatives
mesh[30].descriptor_name	Inositol
mesh[31].qualifier_ui	Q000494
mesh[31].descriptor_ui	D007294
mesh[31].is_major_topic	False
mesh[31].qualifier_name	pharmacology
mesh[31].descriptor_name	Inositol
mesh[32].qualifier_ui
mesh[32].descriptor_ui	D008297
mesh[32].is_major_topic	False
mesh[32].qualifier_name
mesh[32].descriptor_name	Male
mesh[33].qualifier_ui
mesh[33].descriptor_ui	D051379
mesh[33].is_major_topic	False
mesh[33].qualifier_name
mesh[33].descriptor_name	Mice
mesh[34].qualifier_ui	Q000502
mesh[34].descriptor_ui	D017628
mesh[34].is_major_topic	False
mesh[34].qualifier_name	physiology
mesh[34].descriptor_name	Microglia
mesh[35].qualifier_ui	Q000139
mesh[35].descriptor_ui	D010302
mesh[35].is_major_topic	False
mesh[35].qualifier_name	chemically induced
mesh[35].descriptor_name	Parkinson Disease, Secondary
mesh[36].qualifier_ui	Q000201
mesh[36].descriptor_ui	D010302
mesh[36].is_major_topic	False
mesh[36].qualifier_name	enzymology
mesh[36].descriptor_name	Parkinson Disease, Secondary
mesh[37].qualifier_ui	Q000139
mesh[37].descriptor_ui	D066263
mesh[37].is_major_topic	False
mesh[37].qualifier_name	chemically induced
mesh[37].descriptor_name	Protein Aggregation, Pathological
mesh[38].qualifier_ui	Q000201
mesh[38].descriptor_ui	D066263
mesh[38].is_major_topic	False
mesh[38].qualifier_name	enzymology
mesh[38].descriptor_name	Protein Aggregation, Pathological
mesh[39].qualifier_ui	Q000378
mesh[39].descriptor_ui	D011506
mesh[39].is_major_topic	False
mesh[39].qualifier_name	metabolism
mesh[39].descriptor_name	Proteins
mesh[40].qualifier_ui
mesh[40].descriptor_ui	D009435
mesh[40].is_major_topic	False
mesh[40].qualifier_name
mesh[40].descriptor_name	Synaptic Transmission
mesh[41].qualifier_ui	Q000378
mesh[41].descriptor_ui	D051844
mesh[41].is_major_topic	False
mesh[41].qualifier_name	metabolism
mesh[41].descriptor_name	alpha-Synuclein
type	article
title	Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice
biblio.issue	6
biblio.volume	23
biblio.last_page	564
biblio.first_page	550
topics[0].id	https://openalex.org/T10945
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	1.0
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2737
topics[0].subfield.display_name	Physiology
topics[0].display_name	Lysosomal Storage Disorders Research
topics[1].id	https://openalex.org/T10617
topics[1].field.id	https://openalex.org/fields/13
topics[1].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[1].score	0.986299991607666
topics[1].domain.id	https://openalex.org/domains/1
topics[1].domain.display_name	Life Sciences
topics[1].subfield.id	https://openalex.org/subfields/1307
topics[1].subfield.display_name	Cell Biology
topics[1].display_name	Cellular transport and secretion
topics[2].id	https://openalex.org/T10085
topics[2].field.id	https://openalex.org/fields/27
topics[2].field.display_name	Medicine
topics[2].score	0.9839000105857849
topics[2].domain.id	https://openalex.org/domains/4
topics[2].domain.display_name	Health Sciences
topics[2].subfield.id	https://openalex.org/subfields/2728
topics[2].subfield.display_name	Neurology
topics[2].display_name	Parkinson's Disease Mechanisms and Treatments
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C2780674200
concepts[0].level	3
concepts[0].score	0.8444348573684692
concepts[0].wikidata	https://www.wikidata.org/wiki/Q420038
concepts[0].display_name	Glucocerebrosidase
concepts[1].id	https://openalex.org/C2777440831
concepts[1].level	5
concepts[1].score	0.7969386577606201
concepts[1].wikidata	https://www.wikidata.org/wiki/Q2376264
concepts[1].display_name	Synucleinopathies
concepts[2].id	https://openalex.org/C2776925932
concepts[2].level	3
concepts[2].score	0.772408127784729
concepts[2].wikidata	https://www.wikidata.org/wiki/Q1755122
concepts[2].display_name	Neurodegeneration
concepts[3].id	https://openalex.org/C87753298
concepts[3].level	3
concepts[3].score	0.7171987891197205
concepts[3].wikidata	https://www.wikidata.org/wiki/Q17157137
concepts[3].display_name	Neuroinflammation
concepts[4].id	https://openalex.org/C203522944
concepts[4].level	3
concepts[4].score	0.6267129182815552
concepts[4].wikidata	https://www.wikidata.org/wiki/Q288322
concepts[4].display_name	Autophagy
concepts[5].id	https://openalex.org/C2780938664
concepts[5].level	4
concepts[5].score	0.6007914543151855
concepts[5].wikidata	https://www.wikidata.org/wiki/Q753278
concepts[5].display_name	Substantia nigra
concepts[6].id	https://openalex.org/C2781449126
concepts[6].level	4
concepts[6].score	0.5973464250564575
concepts[6].wikidata	https://www.wikidata.org/wiki/Q288591
concepts[6].display_name	Alpha-synuclein
concepts[7].id	https://openalex.org/C2779830541
concepts[7].level	3
concepts[7].score	0.4515015184879303
concepts[7].wikidata	https://www.wikidata.org/wiki/Q1622829
concepts[7].display_name	Microglia
concepts[8].id	https://openalex.org/C2779734285
concepts[8].level	3
concepts[8].score	0.43727830052375793
concepts[8].wikidata	https://www.wikidata.org/wiki/Q11085
concepts[8].display_name	Parkinson's disease
concepts[9].id	https://openalex.org/C95444343
concepts[9].level	1
concepts[9].score	0.4246992766857147
concepts[9].wikidata	https://www.wikidata.org/wiki/Q7141
concepts[9].display_name	Cell biology
concepts[10].id	https://openalex.org/C86803240
concepts[10].level	0
concepts[10].score	0.4230250120162964
concepts[10].wikidata	https://www.wikidata.org/wiki/Q420
concepts[10].display_name	Biology
concepts[11].id	https://openalex.org/C185592680
concepts[11].level	0
concepts[11].score	0.3261982798576355
concepts[11].wikidata	https://www.wikidata.org/wiki/Q2329
concepts[11].display_name	Chemistry
concepts[12].id	https://openalex.org/C169760540
concepts[12].level	1
concepts[12].score	0.3049141764640808
concepts[12].wikidata	https://www.wikidata.org/wiki/Q207011
concepts[12].display_name	Neuroscience
concepts[13].id	https://openalex.org/C55493867
concepts[13].level	1
concepts[13].score	0.254302054643631
concepts[13].wikidata	https://www.wikidata.org/wiki/Q7094
concepts[13].display_name	Biochemistry
concepts[14].id	https://openalex.org/C203014093
concepts[14].level	1
concepts[14].score	0.21596390008926392
concepts[14].wikidata	https://www.wikidata.org/wiki/Q101929
concepts[14].display_name	Immunology
concepts[15].id	https://openalex.org/C2776914184
concepts[15].level	2
concepts[15].score	0.19771885871887207
concepts[15].wikidata	https://www.wikidata.org/wiki/Q101991
concepts[15].display_name	Inflammation
concepts[16].id	https://openalex.org/C71924100
concepts[16].level	0
concepts[16].score	0.17002740502357483
concepts[16].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[16].display_name	Medicine
concepts[17].id	https://openalex.org/C142724271
concepts[17].level	1
concepts[17].score	0.1680285930633545
concepts[17].wikidata	https://www.wikidata.org/wiki/Q7208
concepts[17].display_name	Pathology
concepts[18].id	https://openalex.org/C181199279
concepts[18].level	2
concepts[18].score	0.1410292387008667
concepts[18].wikidata	https://www.wikidata.org/wiki/Q8047
concepts[18].display_name	Enzyme
concepts[19].id	https://openalex.org/C137183658
concepts[19].level	3
concepts[19].score	0.11244824528694153
concepts[19].wikidata	https://www.wikidata.org/wiki/Q461076
concepts[19].display_name	Dopaminergic
concepts[20].id	https://openalex.org/C2779134260
concepts[20].level	2
concepts[20].score	0.09593871235847473
concepts[20].wikidata	https://www.wikidata.org/wiki/Q12136
concepts[20].display_name	Disease
concepts[21].id	https://openalex.org/C513476851
concepts[21].level	2
concepts[21].score	0.08982658386230469
concepts[21].wikidata	https://www.wikidata.org/wiki/Q170304
concepts[21].display_name	Dopamine
concepts[22].id	https://openalex.org/C190283241
concepts[22].level	2
concepts[22].score	0.0
concepts[22].wikidata	https://www.wikidata.org/wiki/Q14599311
concepts[22].display_name	Apoptosis
keywords[0].id	https://openalex.org/keywords/glucocerebrosidase
keywords[0].score	0.8444348573684692
keywords[0].display_name	Glucocerebrosidase
keywords[1].id	https://openalex.org/keywords/synucleinopathies
keywords[1].score	0.7969386577606201
keywords[1].display_name	Synucleinopathies
keywords[2].id	https://openalex.org/keywords/neurodegeneration
keywords[2].score	0.772408127784729
keywords[2].display_name	Neurodegeneration
keywords[3].id	https://openalex.org/keywords/neuroinflammation
keywords[3].score	0.7171987891197205
keywords[3].display_name	Neuroinflammation
keywords[4].id	https://openalex.org/keywords/autophagy
keywords[4].score	0.6267129182815552
keywords[4].display_name	Autophagy
keywords[5].id	https://openalex.org/keywords/substantia-nigra
keywords[5].score	0.6007914543151855
keywords[5].display_name	Substantia nigra
keywords[6].id	https://openalex.org/keywords/alpha-synuclein
keywords[6].score	0.5973464250564575
keywords[6].display_name	Alpha-synuclein
keywords[7].id	https://openalex.org/keywords/microglia
keywords[7].score	0.4515015184879303
keywords[7].display_name	Microglia
keywords[8].id	https://openalex.org/keywords/parkinsons-disease
keywords[8].score	0.43727830052375793
keywords[8].display_name	Parkinson's disease
keywords[9].id	https://openalex.org/keywords/cell-biology
keywords[9].score	0.4246992766857147
keywords[9].display_name	Cell biology
keywords[10].id	https://openalex.org/keywords/biology
keywords[10].score	0.4230250120162964
keywords[10].display_name	Biology
keywords[11].id	https://openalex.org/keywords/chemistry
keywords[11].score	0.3261982798576355
keywords[11].display_name	Chemistry
keywords[12].id	https://openalex.org/keywords/neuroscience
keywords[12].score	0.3049141764640808
keywords[12].display_name	Neuroscience
keywords[13].id	https://openalex.org/keywords/biochemistry
keywords[13].score	0.254302054643631
keywords[13].display_name	Biochemistry
keywords[14].id	https://openalex.org/keywords/immunology
keywords[14].score	0.21596390008926392
keywords[14].display_name	Immunology
keywords[15].id	https://openalex.org/keywords/inflammation
keywords[15].score	0.19771885871887207
keywords[15].display_name	Inflammation
keywords[16].id	https://openalex.org/keywords/medicine
keywords[16].score	0.17002740502357483
keywords[16].display_name	Medicine
keywords[17].id	https://openalex.org/keywords/pathology
keywords[17].score	0.1680285930633545
keywords[17].display_name	Pathology
keywords[18].id	https://openalex.org/keywords/enzyme
keywords[18].score	0.1410292387008667
keywords[18].display_name	Enzyme
keywords[19].id	https://openalex.org/keywords/dopaminergic
keywords[19].score	0.11244824528694153
keywords[19].display_name	Dopaminergic
keywords[20].id	https://openalex.org/keywords/disease
keywords[20].score	0.09593871235847473
keywords[20].display_name	Disease
keywords[21].id	https://openalex.org/keywords/dopamine
keywords[21].score	0.08982658386230469
keywords[21].display_name	Dopamine
language	en
locations[0].id	doi:10.1089/ars.2015.6307
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S88052261
locations[0].source.issn	1523-0864, 1557-7716
locations[0].source.type	journal
locations[0].source.is_oa	False
locations[0].source.issn_l	1523-0864
locations[0].source.is_core	True
locations[0].source.is_in_doaj	False
locations[0].source.display_name	Antioxidants and Redox Signaling
locations[0].source.host_organization	https://openalex.org/P4310320443
locations[0].source.host_organization_name	Mary Ann Liebert, Inc.
locations[0].source.host_organization_lineage	https://openalex.org/P4310320443
locations[0].source.host_organization_lineage_names	Mary Ann Liebert, Inc.
locations[0].license	other-oa
locations[0].pdf_url	https://www.liebertpub.com/doi/pdf/10.1089/ars.2015.6307
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id	https://openalex.org/licenses/other-oa
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	Antioxidants & Redox Signaling
locations[0].landing_page_url	https://doi.org/10.1089/ars.2015.6307
locations[1].id	pmid:26094487
locations[1].is_oa	False
locations[1].source.id	https://openalex.org/S4306525036
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	PubMed
locations[1].source.host_organization	https://openalex.org/I1299303238
locations[1].source.host_organization_name	National Institutes of Health
locations[1].source.host_organization_lineage	https://openalex.org/I1299303238
locations[1].license
locations[1].pdf_url
locations[1].version	publishedVersion
locations[1].raw_type
locations[1].license_id
locations[1].is_accepted	True
locations[1].is_published	True
locations[1].raw_source_name	Antioxidants & redox signaling
locations[1].landing_page_url	https://pubmed.ncbi.nlm.nih.gov/26094487
locations[2].id	pmh:oai:https://orca.cardiff.ac.uk:106219
locations[2].is_oa	False
locations[2].source.id	https://openalex.org/S4306400871
locations[2].source.issn
locations[2].source.type	repository
locations[2].source.is_oa	False
locations[2].source.issn_l
locations[2].source.is_core	False
locations[2].source.is_in_doaj	False
locations[2].source.display_name	Spectrum Research Repository (Concordia University)
locations[2].source.host_organization	https://openalex.org/I60158472
locations[2].source.host_organization_name	Concordia University
locations[2].source.host_organization_lineage	https://openalex.org/I60158472
locations[2].license
locations[2].pdf_url
locations[2].version	submittedVersion
locations[2].raw_type	Article
locations[2].license_id
locations[2].is_accepted	False
locations[2].is_published	False
locations[2].raw_source_name
locations[2].landing_page_url	https://orca.cardiff.ac.uk/id/eprint/106219/
locations[3].id	pmh:oai:pubmedcentral.nih.gov:4544823
locations[3].is_oa	True
locations[3].source.id	https://openalex.org/S2764455111
locations[3].source.issn
locations[3].source.type	repository
locations[3].source.is_oa	False
locations[3].source.issn_l
locations[3].source.is_core	False
locations[3].source.is_in_doaj	False
locations[3].source.display_name	PubMed Central
locations[3].source.host_organization	https://openalex.org/I1299303238
locations[3].source.host_organization_name	National Institutes of Health
locations[3].source.host_organization_lineage	https://openalex.org/I1299303238
locations[3].license
locations[3].pdf_url
locations[3].version	submittedVersion
locations[3].raw_type	Text
locations[3].license_id
locations[3].is_accepted	False
locations[3].is_published	False
locations[3].raw_source_name
locations[3].landing_page_url	http://doi.org/10.1089/ars.2015.6307
indexed_in	crossref, pubmed
authorships[0].author.id	https://openalex.org/A5086878625
authorships[0].author.orcid	https://orcid.org/0000-0003-2171-5104
authorships[0].author.display_name	Emily M. Rocha
authorships[0].countries	US
authorships[0].affiliations[0].institution_ids	https://openalex.org/I136199984
authorships[0].affiliations[0].raw_affiliation_string	1 Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital , Belmont, Massachusetts.
authorships[0].institutions[0].id	https://openalex.org/I136199984
authorships[0].institutions[0].ror	https://ror.org/03vek6s52
authorships[0].institutions[0].type	education
authorships[0].institutions[0].lineage	https://openalex.org/I136199984
authorships[0].institutions[0].country_code	US
authorships[0].institutions[0].display_name	Harvard University
authorships[0].author_position	first
authorships[0].raw_author_name	Emily M. Rocha
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	1 Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital , Belmont, Massachusetts.
authorships[1].author.id	https://openalex.org/A5063647890
authorships[1].author.orcid	https://orcid.org/0000-0003-4332-8383
authorships[1].author.display_name	Gaynor A. Smith
authorships[1].countries	US
authorships[1].affiliations[0].institution_ids	https://openalex.org/I136199984
authorships[1].affiliations[0].raw_affiliation_string	1 Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital , Belmont, Massachusetts.
authorships[1].institutions[0].id	https://openalex.org/I136199984
authorships[1].institutions[0].ror	https://ror.org/03vek6s52
authorships[1].institutions[0].type	education
authorships[1].institutions[0].lineage	https://openalex.org/I136199984
authorships[1].institutions[0].country_code	US
authorships[1].institutions[0].display_name	Harvard University
authorships[1].author_position	middle
authorships[1].raw_author_name	Gaynor A. Smith
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	1 Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital , Belmont, Massachusetts.
authorships[2].author.id	https://openalex.org/A5102958775
authorships[2].author.orcid	https://orcid.org/0009-0000-4876-2846
authorships[2].author.display_name	Eric Park
authorships[2].countries	US
authorships[2].affiliations[0].institution_ids	https://openalex.org/I4210140176
authorships[2].affiliations[0].raw_affiliation_string	2 Shire , Lexington, Massachusetts.
authorships[2].institutions[0].id	https://openalex.org/I4210140176
authorships[2].institutions[0].ror	https://ror.org/03bygaq51
authorships[2].institutions[0].type	company
authorships[2].institutions[0].lineage	https://openalex.org/I4210140176, https://openalex.org/I44892455
authorships[2].institutions[0].country_code	US
authorships[2].institutions[0].display_name	Takeda (United States)
authorships[2].author_position	middle
authorships[2].raw_author_name	Eric Park
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	2 Shire , Lexington, Massachusetts.
authorships[3].author.id	https://openalex.org/A5101636742
authorships[3].author.orcid	https://orcid.org/0000-0003-2096-5785
authorships[3].author.display_name	Hongmei Cao
authorships[3].countries	US
authorships[3].affiliations[0].institution_ids	https://openalex.org/I4210140176
authorships[3].affiliations[0].raw_affiliation_string	2 Shire , Lexington, Massachusetts.
authorships[3].institutions[0].id	https://openalex.org/I4210140176
authorships[3].institutions[0].ror	https://ror.org/03bygaq51
authorships[3].institutions[0].type	company
authorships[3].institutions[0].lineage	https://openalex.org/I4210140176, https://openalex.org/I44892455
authorships[3].institutions[0].country_code	US
authorships[3].institutions[0].display_name	Takeda (United States)
authorships[3].author_position	middle
authorships[3].raw_author_name	Hongmei Cao
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	2 Shire , Lexington, Massachusetts.
authorships[4].author.id	https://openalex.org/A5048326618
authorships[4].author.orcid
authorships[4].author.display_name	Anne-Renee Graham
authorships[4].countries	US
authorships[4].affiliations[0].institution_ids	https://openalex.org/I4210140176
authorships[4].affiliations[0].raw_affiliation_string	2 Shire , Lexington, Massachusetts.
authorships[4].institutions[0].id	https://openalex.org/I4210140176
authorships[4].institutions[0].ror	https://ror.org/03bygaq51
authorships[4].institutions[0].type	company
authorships[4].institutions[0].lineage	https://openalex.org/I4210140176, https://openalex.org/I44892455
authorships[4].institutions[0].country_code	US
authorships[4].institutions[0].display_name	Takeda (United States)
authorships[4].author_position	middle
authorships[4].raw_author_name	Anne-Renee Graham
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	2 Shire , Lexington, Massachusetts.
authorships[5].author.id	https://openalex.org/A5063176425
authorships[5].author.orcid
authorships[5].author.display_name	Eilish Brown
authorships[5].countries	US
authorships[5].affiliations[0].institution_ids	https://openalex.org/I4210140176
authorships[5].affiliations[0].raw_affiliation_string	2 Shire , Lexington, Massachusetts.
authorships[5].institutions[0].id	https://openalex.org/I4210140176
authorships[5].institutions[0].ror	https://ror.org/03bygaq51
authorships[5].institutions[0].type	company
authorships[5].institutions[0].lineage	https://openalex.org/I4210140176, https://openalex.org/I44892455
authorships[5].institutions[0].country_code	US
authorships[5].institutions[0].display_name	Takeda (United States)
authorships[5].author_position	middle
authorships[5].raw_author_name	Eilish Brown
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	2 Shire , Lexington, Massachusetts.
authorships[6].author.id	https://openalex.org/A5030232532
authorships[6].author.orcid
authorships[6].author.display_name	Jesse R. McLean
authorships[6].countries	US
authorships[6].affiliations[0].institution_ids	https://openalex.org/I136199984
authorships[6].affiliations[0].raw_affiliation_string	1 Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital , Belmont, Massachusetts.
authorships[6].institutions[0].id	https://openalex.org/I136199984
authorships[6].institutions[0].ror	https://ror.org/03vek6s52
authorships[6].institutions[0].type	education
authorships[6].institutions[0].lineage	https://openalex.org/I136199984
authorships[6].institutions[0].country_code	US
authorships[6].institutions[0].display_name	Harvard University
authorships[6].author_position	middle
authorships[6].raw_author_name	Jesse R. McLean
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	1 Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital , Belmont, Massachusetts.
authorships[7].author.id	https://openalex.org/A5023763902
authorships[7].author.orcid
authorships[7].author.display_name	Melissa A. Hayes
authorships[7].countries	US
authorships[7].affiliations[0].institution_ids	https://openalex.org/I136199984
authorships[7].affiliations[0].raw_affiliation_string	1 Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital , Belmont, Massachusetts.
authorships[7].institutions[0].id	https://openalex.org/I136199984
authorships[7].institutions[0].ror	https://ror.org/03vek6s52
authorships[7].institutions[0].type	education
authorships[7].institutions[0].lineage	https://openalex.org/I136199984
authorships[7].institutions[0].country_code	US
authorships[7].institutions[0].display_name	Harvard University
authorships[7].author_position	middle
authorships[7].raw_author_name	Melissa A. Hayes
authorships[7].is_corresponding	False
authorships[7].raw_affiliation_strings	1 Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital , Belmont, Massachusetts.
authorships[8].author.id	https://openalex.org/A5049221883
authorships[8].author.orcid	https://orcid.org/0000-0002-7049-3467
authorships[8].author.display_name	Jonathan A. Beagan
authorships[8].countries	US
authorships[8].affiliations[0].institution_ids	https://openalex.org/I136199984
authorships[8].affiliations[0].raw_affiliation_string	1 Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital , Belmont, Massachusetts.
authorships[8].institutions[0].id	https://openalex.org/I136199984
authorships[8].institutions[0].ror	https://ror.org/03vek6s52
authorships[8].institutions[0].type	education
authorships[8].institutions[0].lineage	https://openalex.org/I136199984
authorships[8].institutions[0].country_code	US
authorships[8].institutions[0].display_name	Harvard University
authorships[8].author_position	middle
authorships[8].raw_author_name	Jonathan Beagan
authorships[8].is_corresponding	False
authorships[8].raw_affiliation_strings	1 Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital , Belmont, Massachusetts.
authorships[9].author.id	https://openalex.org/A5007773752
authorships[9].author.orcid	https://orcid.org/0000-0003-1745-524X
authorships[9].author.display_name	Sarah C. Izen
authorships[9].countries	US
authorships[9].affiliations[0].institution_ids	https://openalex.org/I136199984
authorships[9].affiliations[0].raw_affiliation_string	1 Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital , Belmont, Massachusetts.
authorships[9].institutions[0].id	https://openalex.org/I136199984
authorships[9].institutions[0].ror	https://ror.org/03vek6s52
authorships[9].institutions[0].type	education
authorships[9].institutions[0].lineage	https://openalex.org/I136199984
authorships[9].institutions[0].country_code	US
authorships[9].institutions[0].display_name	Harvard University
authorships[9].author_position	middle
authorships[9].raw_author_name	Sarah C. Izen
authorships[9].is_corresponding	False
authorships[9].raw_affiliation_strings	1 Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital , Belmont, Massachusetts.
authorships[10].author.id	https://openalex.org/A5028677374
authorships[10].author.orcid
authorships[10].author.display_name	Eduardo Pérez-Torres
authorships[10].countries	US
authorships[10].affiliations[0].institution_ids	https://openalex.org/I136199984
authorships[10].affiliations[0].raw_affiliation_string	1 Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital , Belmont, Massachusetts.
authorships[10].institutions[0].id	https://openalex.org/I136199984
authorships[10].institutions[0].ror	https://ror.org/03vek6s52
authorships[10].institutions[0].type	education
authorships[10].institutions[0].lineage	https://openalex.org/I136199984
authorships[10].institutions[0].country_code	US
authorships[10].institutions[0].display_name	Harvard University
authorships[10].author_position	middle
authorships[10].raw_author_name	Eduardo Perez-Torres
authorships[10].is_corresponding	False
authorships[10].raw_affiliation_strings	1 Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital , Belmont, Massachusetts.
authorships[11].author.id	https://openalex.org/A5047086211
authorships[11].author.orcid	https://orcid.org/0000-0002-8858-9096
authorships[11].author.display_name	Penelope J. Hallett
authorships[11].countries	US
authorships[11].affiliations[0].institution_ids	https://openalex.org/I136199984
authorships[11].affiliations[0].raw_affiliation_string	1 Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital , Belmont, Massachusetts.
authorships[11].institutions[0].id	https://openalex.org/I136199984
authorships[11].institutions[0].ror	https://ror.org/03vek6s52
authorships[11].institutions[0].type	education
authorships[11].institutions[0].lineage	https://openalex.org/I136199984
authorships[11].institutions[0].country_code	US
authorships[11].institutions[0].display_name	Harvard University
authorships[11].author_position	middle
authorships[11].raw_author_name	Penelope J. Hallett
authorships[11].is_corresponding	False
authorships[11].raw_affiliation_strings	1 Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital , Belmont, Massachusetts.
authorships[12].author.id	https://openalex.org/A5058850275
authorships[12].author.orcid	https://orcid.org/0000-0001-8091-8302
authorships[12].author.display_name	Ole Isacson
authorships[12].countries	US
authorships[12].affiliations[0].institution_ids	https://openalex.org/I136199984
authorships[12].affiliations[0].raw_affiliation_string	1 Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital , Belmont, Massachusetts.
authorships[12].institutions[0].id	https://openalex.org/I136199984
authorships[12].institutions[0].ror	https://ror.org/03vek6s52
authorships[12].institutions[0].type	education
authorships[12].institutions[0].lineage	https://openalex.org/I136199984
authorships[12].institutions[0].country_code	US
authorships[12].institutions[0].display_name	Harvard University
authorships[12].author_position	last
authorships[12].raw_author_name	Ole Isacson
authorships[12].is_corresponding	False
authorships[12].raw_affiliation_strings	1 Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital , Belmont, Massachusetts.
has_content.pdf	True
has_content.grobid_xml	True
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://www.liebertpub.com/doi/pdf/10.1089/ars.2015.6307
open_access.oa_status	hybrid
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice
has_fulltext	True
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T10945
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	1.0
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2737
primary_topic.subfield.display_name	Physiology
primary_topic.display_name	Lysosomal Storage Disorders Research
related_works	https://openalex.org/W2020167843, https://openalex.org/W2114800281, https://openalex.org/W2006380359, https://openalex.org/W1982224533, https://openalex.org/W2907961615, https://openalex.org/W2906463067, https://openalex.org/W2289631923, https://openalex.org/W2591558604, https://openalex.org/W2031365272, https://openalex.org/W2765638828
cited_by_count	144
counts_by_year[0].year	2025
counts_by_year[0].cited_by_count	11
counts_by_year[1].year	2024
counts_by_year[1].cited_by_count	18
counts_by_year[2].year	2023
counts_by_year[2].cited_by_count	16
counts_by_year[3].year	2022
counts_by_year[3].cited_by_count	21
counts_by_year[4].year	2021
counts_by_year[4].cited_by_count	19
counts_by_year[5].year	2020
counts_by_year[5].cited_by_count	15
counts_by_year[6].year	2019
counts_by_year[6].cited_by_count	17
counts_by_year[7].year	2018
counts_by_year[7].cited_by_count	13
counts_by_year[8].year	2017
counts_by_year[8].cited_by_count	7
counts_by_year[9].year	2016
counts_by_year[9].cited_by_count	5
counts_by_year[10].year	2015
counts_by_year[10].cited_by_count	1
counts_by_year[11].year	2012
counts_by_year[11].cited_by_count	1
locations_count	4
best_oa_location.id	doi:10.1089/ars.2015.6307
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S88052261
best_oa_location.source.issn	1523-0864, 1557-7716
best_oa_location.source.type	journal
best_oa_location.source.is_oa	False
best_oa_location.source.issn_l	1523-0864
best_oa_location.source.is_core	True
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	Antioxidants and Redox Signaling
best_oa_location.source.host_organization	https://openalex.org/P4310320443
best_oa_location.source.host_organization_name	Mary Ann Liebert, Inc.
best_oa_location.source.host_organization_lineage	https://openalex.org/P4310320443
best_oa_location.source.host_organization_lineage_names	Mary Ann Liebert, Inc.
best_oa_location.license	other-oa
best_oa_location.pdf_url	https://www.liebertpub.com/doi/pdf/10.1089/ars.2015.6307
best_oa_location.version	publishedVersion
best_oa_location.raw_type	journal-article
best_oa_location.license_id	https://openalex.org/licenses/other-oa
best_oa_location.is_accepted	True
best_oa_location.is_published	True
best_oa_location.raw_source_name	Antioxidants & Redox Signaling
best_oa_location.landing_page_url	https://doi.org/10.1089/ars.2015.6307
primary_location.id	doi:10.1089/ars.2015.6307
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S88052261
primary_location.source.issn	1523-0864, 1557-7716
primary_location.source.type	journal
primary_location.source.is_oa	False
primary_location.source.issn_l	1523-0864
primary_location.source.is_core	True
primary_location.source.is_in_doaj	False
primary_location.source.display_name	Antioxidants and Redox Signaling
primary_location.source.host_organization	https://openalex.org/P4310320443
primary_location.source.host_organization_name	Mary Ann Liebert, Inc.
primary_location.source.host_organization_lineage	https://openalex.org/P4310320443
primary_location.source.host_organization_lineage_names	Mary Ann Liebert, Inc.
primary_location.license	other-oa
primary_location.pdf_url	https://www.liebertpub.com/doi/pdf/10.1089/ars.2015.6307
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id	https://openalex.org/licenses/other-oa
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	Antioxidants & Redox Signaling
primary_location.landing_page_url	https://doi.org/10.1089/ars.2015.6307
publication_date	2015-06-21
publication_year	2015
referenced_works	https://openalex.org/W2026969412, https://openalex.org/W2075480683, https://openalex.org/W2038233263, https://openalex.org/W2151498098, https://openalex.org/W2123202217, https://openalex.org/W2123184492, https://openalex.org/W2049404795, https://openalex.org/W1990294498, https://openalex.org/W1989734945, https://openalex.org/W1968322176, https://openalex.org/W2068288454, https://openalex.org/W2121981334, https://openalex.org/W2163628807, https://openalex.org/W2076743021, https://openalex.org/W1987183038, https://openalex.org/W2035258856, https://openalex.org/W2148937096, https://openalex.org/W2137606977, https://openalex.org/W1644582274, https://openalex.org/W1996637092, https://openalex.org/W2169923780, https://openalex.org/W2028072328, https://openalex.org/W4242804477, https://openalex.org/W2056516960, https://openalex.org/W1501325364, https://openalex.org/W2007348345, https://openalex.org/W2164778558, https://openalex.org/W1987360305, https://openalex.org/W2008864875, https://openalex.org/W1992659717, https://openalex.org/W4210952882, https://openalex.org/W264722788, https://openalex.org/W2133919038, https://openalex.org/W2137686667, https://openalex.org/W1993467627, https://openalex.org/W2163570079, https://openalex.org/W2031365272, https://openalex.org/W2057784346, https://openalex.org/W1980947632, https://openalex.org/W1993771442, https://openalex.org/W2144140825, https://openalex.org/W2009573330, https://openalex.org/W2071494035, https://openalex.org/W2165400844, https://openalex.org/W1987155530, https://openalex.org/W2082307109, https://openalex.org/W1984979116, https://openalex.org/W1975932268, https://openalex.org/W1982224533, https://openalex.org/W2020167843, https://openalex.org/W2077499130, https://openalex.org/W2033617297, https://openalex.org/W2022884184, https://openalex.org/W2168784140, https://openalex.org/W2170281382, https://openalex.org/W1965481483, https://openalex.org/W2123746730, https://openalex.org/W2096327192, https://openalex.org/W2033451896, https://openalex.org/W1973738022, https://openalex.org/W2127342428, https://openalex.org/W2055487675, https://openalex.org/W2073861040, https://openalex.org/W2142047537, https://openalex.org/W2127513771, https://openalex.org/W2010443783, https://openalex.org/W2132958650, https://openalex.org/W2115557750, https://openalex.org/W4285719527, https://openalex.org/W2419405744
referenced_works_count	70
abstract_inverted_index.a	3
abstract_inverted_index.PD	29
abstract_inverted_index.in	16, 28
abstract_inverted_index.of	11, 22
abstract_inverted_index.to	25
abstract_inverted_index.and	8, 13, 18, 30
abstract_inverted_index.the	9, 20
abstract_inverted_index.data	1
abstract_inverted_index.link	4
abstract_inverted_index.GCase	23
abstract_inverted_index.These	0
abstract_inverted_index.mice,	17
abstract_inverted_index.reduce	26
abstract_inverted_index.reveal	2
abstract_inverted_index.between	5
abstract_inverted_index.reduced	6
abstract_inverted_index.related	31
abstract_inverted_index.support	19
abstract_inverted_index.disorders.	32
abstract_inverted_index.development	10, 21
abstract_inverted_index.therapeutics	24
abstract_inverted_index.abnormalities	15
abstract_inverted_index.glucocerebrosidase	7
abstract_inverted_index.pathophysiological	14
abstract_inverted_index.α-synucleinopathy	12, 27
cited_by_percentile_year.max	100
cited_by_percentile_year.min	89
countries_distinct_count	1
institutions_distinct_count	13
citation_normalized_percentile.value	0.95346259
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	True