Synchronization, clustering, and weak chimeras in a densely coupled transcription-based oscillator model for split circadian rhythms Article Swipe
Jorge Luis Ocampo‐Espindola
,
K. L. Nikhil
,
Jr-Shin Li
,
Erik D. Herzog
,
István Z. Kiss
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1063/5.0156135
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1063/5.0156135
The synchronization dynamics for the circadian gene expression in the suprachiasmatic nucleus is investigated using a transcriptional circadian clock gene oscillator model. With global coupling in constant dark (DD) conditions, the model exhibits a one-cluster phase synchronized state, in dim light (dim LL), bistability between one- and two-cluster states and in bright LL, a two-cluster state. The two-cluster phase synchronized state, where some oscillator pairs synchronize in-phase, and some anti-phase, can explain the splitting of the circadian clock, i.e., generation of two bouts of daily activities with certain species, e.g., with hamsters. The one- and two-cluster states can be reached by transferring the animal from DD or bright LL to dim LL, i.e., the circadian synchrony has a memory effect. The stability of the one- and two-cluster states was interpreted analytically by extracting phase models from the ordinary differential equation models. In a modular network with two strongly coupled oscillator populations with weak intragroup coupling, with appropriate initial conditions, one group is synchronized to the one-cluster state and the other group to the two-cluster state, resulting in a weak-chimera state. Computational modeling suggests that the daily rhythms in sleep–wake depend on light intensity acting on bilateral networks of suprachiasmatic nucleus (SCN) oscillators. Addition of a network heterogeneity (coupling between the left and right SCN) allowed the system to exhibit chimera states. The simulations can guide experiments in the circadian rhythm research to explore the effect of light intensity on the complexities of circadian desynchronization.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1063/5.0156135
- https://pubs.aip.org/aip/cha/article-pdf/doi/10.1063/5.0156135/18072302/083105_1_5.0156135.pdf
- OA Status
- bronze
- Cited By
- 5
- References
- 80
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4385514481
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4385514481Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1063/5.0156135Digital Object Identifier
- Title
-
Synchronization, clustering, and weak chimeras in a densely coupled transcription-based oscillator model for split circadian rhythmsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-08-01Full publication date if available
- Authors
-
Jorge Luis Ocampo‐Espindola, K. L. Nikhil, Jr-Shin Li, Erik D. Herzog, István Z. KissList of authors in order
- Landing page
-
https://doi.org/10.1063/5.0156135Publisher landing page
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https://pubs.aip.org/aip/cha/article-pdf/doi/10.1063/5.0156135/18072302/083105_1_5.0156135.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
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https://pubs.aip.org/aip/cha/article-pdf/doi/10.1063/5.0156135/18072302/083105_1_5.0156135.pdfDirect OA link when available
- Concepts
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Circadian rhythm, Rhythm, Synchronization (alternating current), Circadian clock, Biology, Cluster analysis, Bacterial circadian rhythms, Neuroscience, Computer science, Physics, Telecommunications, Artificial intelligence, Acoustics, Channel (broadcasting)Top concepts (fields/topics) attached by OpenAlex
- Cited by
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5Total citation count in OpenAlex
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2025: 3, 2024: 2Per-year citation counts (last 5 years)
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80Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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