Synergic effect of tau tangles and cortical thinning on cognitive decline in aging and Alzheimer’s disease Article Swipe
Lydia Trudel
,
Joseph Therriault
,
Nesrine Rahmouni
,
Étienne Aumont
,
Yi‐Ting Wang
,
Stijn Servaes
,
Arthur C. Macedo
,
Tevy Chan
,
Jaime Fernández Arias
,
Brandon J. Hall
,
Seyyed Ali Hosseini
,
Kely Monica Quispialaya Socualaya
,
Sulantha Mathotaarachchi
,
Jenna Stevenson
,
Firoza Z Lussier
,
Serge Gauthier
,
Tharick A. Pascoal
,
Pedro Rosa‐Neto
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/alz.085973
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/alz.085973
Background Tau burden has been found to be involved in brain atrophy during aging, especially in regions such as the parahippocampal gyrus. However, how tau levels at baseline are associated with trajectories of tau accumulation, cortical thinning and cognitive impairment remains poorly understood. The goal of this study was to assess tau rate of change in patients between baseline Tau+ and Tau‐ patients. We also aimed to determine if tau status at baseline or rate of accumulation of tau interacted with the rate of cortical thinning of the parahippocampal regions, leading to an increased rate of change in cognition. Method We assessed 133 participants from the TRIAD cohort (mean age = 68.5 ± 8.9, 85 females) with at least two visits with tau‐PET using [ 18 F]MK6240 and cortical thickness extracted using FreeSurfer 7. Average time between visits was 25.6 months. Patients were classified according to clinical status, Amyloid‐β status and tau status at baseline (CU AB‐Tau‐, CU AB+Tau‐, CU AB+Tau+, MCI AB+Tau‐, MCI AB+Tau+, AD AB+Tau+). The tau‐PET rate of change was calculated for each participant, voxelwise and with temporal meta‐ROI. The MMSE rate of change was calculated to quantify cognitive decline over follow‐up period. We assessed the voxelwise relationship between baseline tau status and tau‐PET rate of change. Results We found a voxelwise positive association between rate of accumulation of tau and tau status at baseline in both anterior temporal lobes. Furthermore, we found an interaction effect between tau‐PET at baseline and parahippocampal rate of atrophy on MMSE rate of change (standardized β = 0.48, p < 0.0001). Conclusion Our results suggest that tau status at baseline might impact the rate of accumulation of tau, and that higher baseline levels of tau interact with cortical thinning of parahippocampal regions, leading to faster rates of cognitive decline. Our results emphasize the importance of preventing tau burden to prevent faster pace of cognitive decline during the disease’s trajectory.
Related Topics
Concepts
Disease
Cognitive decline
Thinning
Neuroscience
Medicine
Psychology
Dementia
Internal medicine
Biology
Ecology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/alz.085973
- OA Status
- hybrid
- Related Works
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- OpenAlex ID
- https://openalex.org/W4406201180
All OpenAlex metadata
Raw OpenAlex JSON
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https://doi.org/10.1002/alz.085973Digital Object Identifier
- Title
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Synergic effect of tau tangles and cortical thinning on cognitive decline in aging and Alzheimer’s diseaseWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-12-01Full publication date if available
- Authors
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Lydia Trudel, Joseph Therriault, Nesrine Rahmouni, Étienne Aumont, Yi‐Ting Wang, Stijn Servaes, Arthur C. Macedo, Tevy Chan, Jaime Fernández Arias, Brandon J. Hall, Seyyed Ali Hosseini, Kely Monica Quispialaya Socualaya, Sulantha Mathotaarachchi, Jenna Stevenson, Firoza Z Lussier, Serge Gauthier, Tharick A. Pascoal, Pedro Rosa‐NetoList of authors in order
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https://doi.org/10.1002/alz.085973Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1002/alz.085973Direct OA link when available
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Disease, Cognitive decline, Thinning, Neuroscience, Medicine, Psychology, Dementia, Internal medicine, Biology, EcologyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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| abstract_inverted_index.AB‐Tau‐, | 157 |
| abstract_inverted_index.Amyloid‐β | 149 |
| abstract_inverted_index.Furthermore, | 234 |
| abstract_inverted_index.accumulation | 77, 221, 275 |
| abstract_inverted_index.participant, | 177 |
| abstract_inverted_index.participants | 104 |
| abstract_inverted_index.relationship | 201 |
| abstract_inverted_index.trajectories | 32 |
| abstract_inverted_index.(standardized | 254 |
| abstract_inverted_index.accumulation, | 35 |
| abstract_inverted_index.parahippocampal | 21, 89, 245, 290 |
| cited_by_percentile_year | |
| countries_distinct_count | 2 |
| institutions_distinct_count | 18 |
| citation_normalized_percentile.value | 0.34200304 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |