Synergistic effect of teclistamab with PD-1 inhibition: a case of acute interstitial nephritis with dual immunotherapy Article Swipe
Arjunmohan Mohan
,
Elena-Bianca Barbir
,
Loren Herrera Hernandez
,
Nelson Leung
,
Sandra M. Herrmann
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/ckj/sfae425
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/ckj/sfae425
We report a case of acute interstitial nephritis (AIN) in a 68-year-old male with squamous cell carcinoma (SCC) and relapsed/refractory multiple myeloma (RRMM) who developed acute kidney injury (AKI) shortly after starting teclistamab for RRMM. Despite stable renal function on immune checkpoint inhibitor (ICI) therapy for SCC, proton pump inhibitors and trimethoprim-sulfamethoxazole for 3 years, AKI only occurred post-teclistamab initiation. Biopsy-confirmed AIN with serum creatinine improved only after pulse-dose steroids. This case highlights a potential synergistic nephrotoxic effect of teclistamab and ICIs, warranting further investigation into teclistamab's renal safety.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/ckj/sfae425
- https://academic.oup.com/ckj/advance-article-pdf/doi/10.1093/ckj/sfae425/61249975/sfae425.pdf
- OA Status
- gold
- Cited By
- 1
- References
- 4
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4405680133
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4405680133Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/ckj/sfae425Digital Object Identifier
- Title
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Synergistic effect of teclistamab with PD-1 inhibition: a case of acute interstitial nephritis with dual immunotherapyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-12-20Full publication date if available
- Authors
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Arjunmohan Mohan, Elena-Bianca Barbir, Loren Herrera Hernandez, Nelson Leung, Sandra M. HerrmannList of authors in order
- Landing page
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https://doi.org/10.1093/ckj/sfae425Publisher landing page
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https://academic.oup.com/ckj/advance-article-pdf/doi/10.1093/ckj/sfae425/61249975/sfae425.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://academic.oup.com/ckj/advance-article-pdf/doi/10.1093/ckj/sfae425/61249975/sfae425.pdfDirect OA link when available
- Concepts
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Dual (grammatical number), Immunotherapy, Medicine, Interstitial nephritis, Nephritis, Dual role, Cancer research, Immunology, Internal medicine, Chemistry, Immune system, Kidney, Philosophy, Combinatorial chemistry, LinguisticsTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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4Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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