Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway Article Swipe
Dawei Lei
,
Zhengbo Shao
,
Xinrong Zhou
,
Huiping Yuan
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.18632/oncotarget.24343
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.18632/oncotarget.24343
Retinal ischemia-reperfusion (RIR) injury causes neuronal degeneration and initiates various optic nerve diseases. This study aimed to investigate the synergistic neuroprotective effect of rasagiline and idebenone against RIR injury. A combination of rasagiline and idebenone was administered intraperitoneally immediately after establishment of the RIR model. Treatment with the combination of the two drugs resulted in a significant restoration of retinal thickness and retinal ganglion cells. Apoptosis of cells in ganglion cell layers was also ameliorated, suggesting that the effect of the two drugs was synergistic and the expression of brain-derived neurotrophic factor increased. Furthermore, idebenone and rasagiline induced the expression of Lin28A and Lin28B, respectively, which resulted in a reduced expression of microRNAs in the let-7 family and an increased protein output of Dicer. The data obtained from gene overexpression and knockdown experiments indicated that let-7 and Dicer were necessary for the synergistic neuroprotective effect of the two drugs. Our findings suggested that combination therapy with rasagiline and idebenone produced a synergistic effect that ameliorated RIR injury and restored visual function. In addition, the combined treatment provided neuroprotection via enhancement of the selective regulation of let-7 by Lin28A/B. These findings implied that a treatment with the combination of rasagiline and idebenone is a feasible treatment option for optic nerve diseases.
Related Topics
Concepts
Idebenone
Neuroprotection
Rasagiline
Pharmacology
Medicine
Dicer
Ischemia
Chemistry
Internal medicine
Biochemistry
RNA interference
Parkinson's disease
Disease
RNA
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.18632/oncotarget.24343
- http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=24343&path%5B%5D=76470
- OA Status
- diamond
- Cited By
- 25
- References
- 55
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2788707201
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2788707201Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.18632/oncotarget.24343Digital Object Identifier
- Title
-
Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathwayWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-01-30Full publication date if available
- Authors
-
Dawei Lei, Zhengbo Shao, Xinrong Zhou, Huiping YuanList of authors in order
- Landing page
-
https://doi.org/10.18632/oncotarget.24343Publisher landing page
- PDF URL
-
https://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=24343&path%5B%5D=76470Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=24343&path%5B%5D=76470Direct OA link when available
- Concepts
-
Idebenone, Neuroprotection, Rasagiline, Pharmacology, Medicine, Dicer, Ischemia, Chemistry, Internal medicine, Biochemistry, RNA interference, Parkinson's disease, Disease, RNA, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
25Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 3, 2023: 3, 2022: 5, 2021: 5Per-year citation counts (last 5 years)
- References (count)
-
55Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2788707201 |
|---|---|
| doi | https://doi.org/10.18632/oncotarget.24343 |
| ids.doi | https://doi.org/10.18632/oncotarget.24343 |
| ids.mag | 2788707201 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/29552298 |
| ids.openalex | https://openalex.org/W2788707201 |
| fwci | 1.65132694 |
| type | article |
| title | Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway |
| biblio.issue | 15 |
| biblio.volume | 9 |
| biblio.last_page | 12153 |
| biblio.first_page | 12137 |
| topics[0].id | https://openalex.org/T11266 |
| topics[0].field.id | https://openalex.org/fields/28 |
| topics[0].field.display_name | Neuroscience |
| topics[0].score | 0.9965000152587891 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2808 |
| topics[0].subfield.display_name | Neurology |
| topics[0].display_name | Neuroinflammation and Neurodegeneration Mechanisms |
| topics[1].id | https://openalex.org/T10691 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9912999868392944 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Retinal Development and Disorders |
| topics[2].id | https://openalex.org/T10587 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.989300012588501 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2713 |
| topics[2].subfield.display_name | Epidemiology |
| topics[2].display_name | Autophagy in Disease and Therapy |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2777403772 |
| concepts[0].level | 2 |
| concepts[0].score | 0.910494863986969 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q4197874 |
| concepts[0].display_name | Idebenone |
| concepts[1].id | https://openalex.org/C25498285 |
| concepts[1].level | 2 |
| concepts[1].score | 0.8694526553153992 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q1981368 |
| concepts[1].display_name | Neuroprotection |
| concepts[2].id | https://openalex.org/C2781249495 |
| concepts[2].level | 4 |
| concepts[2].score | 0.8176184892654419 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q420685 |
| concepts[2].display_name | Rasagiline |
| concepts[3].id | https://openalex.org/C98274493 |
| concepts[3].level | 1 |
| concepts[3].score | 0.7037950158119202 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[3].display_name | Pharmacology |
| concepts[4].id | https://openalex.org/C71924100 |
| concepts[4].level | 0 |
| concepts[4].score | 0.6270791888237 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[4].display_name | Medicine |
| concepts[5].id | https://openalex.org/C2779867133 |
| concepts[5].level | 5 |
| concepts[5].score | 0.5100999474525452 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q21111297 |
| concepts[5].display_name | Dicer |
| concepts[6].id | https://openalex.org/C541997718 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4424440562725067 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q188151 |
| concepts[6].display_name | Ischemia |
| concepts[7].id | https://openalex.org/C185592680 |
| concepts[7].level | 0 |
| concepts[7].score | 0.18380272388458252 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[7].display_name | Chemistry |
| concepts[8].id | https://openalex.org/C126322002 |
| concepts[8].level | 1 |
| concepts[8].score | 0.16662535071372986 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[8].display_name | Internal medicine |
| concepts[9].id | https://openalex.org/C55493867 |
| concepts[9].level | 1 |
| concepts[9].score | 0.14931344985961914 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[9].display_name | Biochemistry |
| concepts[10].id | https://openalex.org/C166703698 |
| concepts[10].level | 4 |
| concepts[10].score | 0.1217704713344574 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q201993 |
| concepts[10].display_name | RNA interference |
| concepts[11].id | https://openalex.org/C2779734285 |
| concepts[11].level | 3 |
| concepts[11].score | 0.06594660878181458 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q11085 |
| concepts[11].display_name | Parkinson's disease |
| concepts[12].id | https://openalex.org/C2779134260 |
| concepts[12].level | 2 |
| concepts[12].score | 0.0 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[12].display_name | Disease |
| concepts[13].id | https://openalex.org/C67705224 |
| concepts[13].level | 3 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q11053 |
| concepts[13].display_name | RNA |
| concepts[14].id | https://openalex.org/C104317684 |
| concepts[14].level | 2 |
| concepts[14].score | 0.0 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[14].display_name | Gene |
| keywords[0].id | https://openalex.org/keywords/idebenone |
| keywords[0].score | 0.910494863986969 |
| keywords[0].display_name | Idebenone |
| keywords[1].id | https://openalex.org/keywords/neuroprotection |
| keywords[1].score | 0.8694526553153992 |
| keywords[1].display_name | Neuroprotection |
| keywords[2].id | https://openalex.org/keywords/rasagiline |
| keywords[2].score | 0.8176184892654419 |
| keywords[2].display_name | Rasagiline |
| keywords[3].id | https://openalex.org/keywords/pharmacology |
| keywords[3].score | 0.7037950158119202 |
| keywords[3].display_name | Pharmacology |
| keywords[4].id | https://openalex.org/keywords/medicine |
| keywords[4].score | 0.6270791888237 |
| keywords[4].display_name | Medicine |
| keywords[5].id | https://openalex.org/keywords/dicer |
| keywords[5].score | 0.5100999474525452 |
| keywords[5].display_name | Dicer |
| keywords[6].id | https://openalex.org/keywords/ischemia |
| keywords[6].score | 0.4424440562725067 |
| keywords[6].display_name | Ischemia |
| keywords[7].id | https://openalex.org/keywords/chemistry |
| keywords[7].score | 0.18380272388458252 |
| keywords[7].display_name | Chemistry |
| keywords[8].id | https://openalex.org/keywords/internal-medicine |
| keywords[8].score | 0.16662535071372986 |
| keywords[8].display_name | Internal medicine |
| keywords[9].id | https://openalex.org/keywords/biochemistry |
| keywords[9].score | 0.14931344985961914 |
| keywords[9].display_name | Biochemistry |
| keywords[10].id | https://openalex.org/keywords/rna-interference |
| keywords[10].score | 0.1217704713344574 |
| keywords[10].display_name | RNA interference |
| keywords[11].id | https://openalex.org/keywords/parkinsons-disease |
| keywords[11].score | 0.06594660878181458 |
| keywords[11].display_name | Parkinson's disease |
| language | en |
| locations[0].id | doi:10.18632/oncotarget.24343 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S126644158 |
| locations[0].source.issn | 1949-2553 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1949-2553 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Oncotarget |
| locations[0].source.host_organization | https://openalex.org/P4310316297 |
| locations[0].source.host_organization_name | Impact Journals LLC |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310316297 |
| locations[0].license | cc-by |
| locations[0].pdf_url | http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=24343&path%5B%5D=76470 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Oncotarget |
| locations[0].landing_page_url | https://doi.org/10.18632/oncotarget.24343 |
| locations[1].id | pmid:29552298 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Oncotarget |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/29552298 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:5844734 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Oncotarget |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/5844734 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5016400829 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Dawei Lei |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I156144747, https://openalex.org/I4210132813 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Ophthalmology, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China |
| authorships[0].institutions[0].id | https://openalex.org/I156144747 |
| authorships[0].institutions[0].ror | https://ror.org/05jscf583 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I156144747 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Harbin Medical University |
| authorships[0].institutions[1].id | https://openalex.org/I4210132813 |
| authorships[0].institutions[1].ror | https://ror.org/03s8txj32 |
| authorships[0].institutions[1].type | healthcare |
| authorships[0].institutions[1].lineage | https://openalex.org/I4210132813 |
| authorships[0].institutions[1].country_code | CN |
| authorships[0].institutions[1].display_name | Second Affiliated Hospital of Harbin Medical University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Dawei Lei |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Ophthalmology, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China |
| authorships[1].author.id | https://openalex.org/A5073741770 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-4695-8305 |
| authorships[1].author.display_name | Zhengbo Shao |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I156144747, https://openalex.org/I4210132813 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Ophthalmology, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China |
| authorships[1].institutions[0].id | https://openalex.org/I156144747 |
| authorships[1].institutions[0].ror | https://ror.org/05jscf583 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I156144747 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Harbin Medical University |
| authorships[1].institutions[1].id | https://openalex.org/I4210132813 |
| authorships[1].institutions[1].ror | https://ror.org/03s8txj32 |
| authorships[1].institutions[1].type | healthcare |
| authorships[1].institutions[1].lineage | https://openalex.org/I4210132813 |
| authorships[1].institutions[1].country_code | CN |
| authorships[1].institutions[1].display_name | Second Affiliated Hospital of Harbin Medical University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Zhengbo Shao |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Ophthalmology, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China |
| authorships[2].author.id | https://openalex.org/A5114030106 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Xinrong Zhou |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I156144747, https://openalex.org/I4210132813 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Ophthalmology, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China |
| authorships[2].institutions[0].id | https://openalex.org/I156144747 |
| authorships[2].institutions[0].ror | https://ror.org/05jscf583 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I156144747 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Harbin Medical University |
| authorships[2].institutions[1].id | https://openalex.org/I4210132813 |
| authorships[2].institutions[1].ror | https://ror.org/03s8txj32 |
| authorships[2].institutions[1].type | healthcare |
| authorships[2].institutions[1].lineage | https://openalex.org/I4210132813 |
| authorships[2].institutions[1].country_code | CN |
| authorships[2].institutions[1].display_name | Second Affiliated Hospital of Harbin Medical University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Xinrong Zhou |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Ophthalmology, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China |
| authorships[3].author.id | https://openalex.org/A5101663699 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-8750-6191 |
| authorships[3].author.display_name | Huiping Yuan |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I156144747, https://openalex.org/I4210132813 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Ophthalmology, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China |
| authorships[3].institutions[0].id | https://openalex.org/I156144747 |
| authorships[3].institutions[0].ror | https://ror.org/05jscf583 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I156144747 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Harbin Medical University |
| authorships[3].institutions[1].id | https://openalex.org/I4210132813 |
| authorships[3].institutions[1].ror | https://ror.org/03s8txj32 |
| authorships[3].institutions[1].type | healthcare |
| authorships[3].institutions[1].lineage | https://openalex.org/I4210132813 |
| authorships[3].institutions[1].country_code | CN |
| authorships[3].institutions[1].display_name | Second Affiliated Hospital of Harbin Medical University |
| authorships[3].author_position | last |
| authorships[3].raw_author_name | Huiping Yuan |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Ophthalmology, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=24343&path%5B%5D=76470 |
| open_access.oa_status | diamond |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11266 |
| primary_topic.field.id | https://openalex.org/fields/28 |
| primary_topic.field.display_name | Neuroscience |
| primary_topic.score | 0.9965000152587891 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2808 |
| primary_topic.subfield.display_name | Neurology |
| primary_topic.display_name | Neuroinflammation and Neurodegeneration Mechanisms |
| related_works | https://openalex.org/W2094629462, https://openalex.org/W2390264603, https://openalex.org/W2913172157, https://openalex.org/W1985502451, https://openalex.org/W2064240001, https://openalex.org/W2788707201, https://openalex.org/W98161189, https://openalex.org/W2410672174, https://openalex.org/W2066913392, https://openalex.org/W2919770770 |
| cited_by_count | 25 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 3 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 3 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 5 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 5 |
| counts_by_year[5].year | 2020 |
| counts_by_year[5].cited_by_count | 5 |
| counts_by_year[6].year | 2019 |
| counts_by_year[6].cited_by_count | 1 |
| counts_by_year[7].year | 2018 |
| counts_by_year[7].cited_by_count | 1 |
| locations_count | 3 |
| best_oa_location.id | doi:10.18632/oncotarget.24343 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S126644158 |
| best_oa_location.source.issn | 1949-2553 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1949-2553 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Oncotarget |
| best_oa_location.source.host_organization | https://openalex.org/P4310316297 |
| best_oa_location.source.host_organization_name | Impact Journals LLC |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310316297 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=24343&path%5B%5D=76470 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Oncotarget |
| best_oa_location.landing_page_url | https://doi.org/10.18632/oncotarget.24343 |
| primary_location.id | doi:10.18632/oncotarget.24343 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S126644158 |
| primary_location.source.issn | 1949-2553 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1949-2553 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Oncotarget |
| primary_location.source.host_organization | https://openalex.org/P4310316297 |
| primary_location.source.host_organization_name | Impact Journals LLC |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310316297 |
| primary_location.license | cc-by |
| primary_location.pdf_url | http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=24343&path%5B%5D=76470 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Oncotarget |
| primary_location.landing_page_url | https://doi.org/10.18632/oncotarget.24343 |
| publication_date | 2018-01-30 |
| publication_year | 2018 |
| referenced_works | https://openalex.org/W1982422365, https://openalex.org/W2093073160, https://openalex.org/W267801964, https://openalex.org/W2127176298, https://openalex.org/W2342957942, https://openalex.org/W1964987417, https://openalex.org/W353261369, https://openalex.org/W2415965336, https://openalex.org/W2146819974, https://openalex.org/W2323333461, https://openalex.org/W2079343445, https://openalex.org/W2005103775, https://openalex.org/W1906327883, https://openalex.org/W992989925, https://openalex.org/W1993959309, https://openalex.org/W2034806022, https://openalex.org/W2124112939, https://openalex.org/W1969698545, https://openalex.org/W2466272585, https://openalex.org/W1972717420, https://openalex.org/W1979710386, https://openalex.org/W2021330818, https://openalex.org/W1981787317, https://openalex.org/W2062171726, https://openalex.org/W1971317397, https://openalex.org/W2120778802, https://openalex.org/W2098559329, https://openalex.org/W2591411653, https://openalex.org/W4254771604, https://openalex.org/W2019167811, https://openalex.org/W2172157901, https://openalex.org/W2060907567, https://openalex.org/W2102406841, https://openalex.org/W1980257381, https://openalex.org/W1986493401, https://openalex.org/W2000446926, https://openalex.org/W2034122901, https://openalex.org/W2008456822, https://openalex.org/W2385522828, https://openalex.org/W1996032414, https://openalex.org/W2060787577, https://openalex.org/W2318853101, https://openalex.org/W2550624398, https://openalex.org/W2075652797, https://openalex.org/W1982178700, https://openalex.org/W2561772137, https://openalex.org/W2002483881, https://openalex.org/W1938436444, https://openalex.org/W2531444520, https://openalex.org/W2281405694, https://openalex.org/W2560199324, https://openalex.org/W2167027929, https://openalex.org/W1523693806, https://openalex.org/W2135706825, https://openalex.org/W2736362061 |
| referenced_works_count | 55 |
| abstract_inverted_index.A | 29 |
| abstract_inverted_index.a | 55, 108, 160, 192, 202 |
| abstract_inverted_index.In | 171 |
| abstract_inverted_index.an | 118 |
| abstract_inverted_index.by | 186 |
| abstract_inverted_index.in | 54, 68, 107, 113 |
| abstract_inverted_index.is | 201 |
| abstract_inverted_index.of | 22, 31, 41, 49, 58, 66, 79, 88, 100, 111, 122, 145, 180, 184, 197 |
| abstract_inverted_index.to | 16 |
| abstract_inverted_index.Our | 149 |
| abstract_inverted_index.RIR | 27, 43, 165 |
| abstract_inverted_index.The | 124 |
| abstract_inverted_index.and | 7, 24, 33, 61, 85, 95, 102, 117, 130, 136, 157, 167, 199 |
| abstract_inverted_index.for | 140, 206 |
| abstract_inverted_index.the | 18, 42, 47, 50, 77, 80, 86, 98, 114, 141, 146, 173, 181, 195 |
| abstract_inverted_index.two | 51, 81, 147 |
| abstract_inverted_index.via | 178 |
| abstract_inverted_index.was | 35, 72, 83 |
| abstract_inverted_index.This | 13 |
| abstract_inverted_index.also | 73 |
| abstract_inverted_index.cell | 70 |
| abstract_inverted_index.data | 125 |
| abstract_inverted_index.from | 127 |
| abstract_inverted_index.gene | 128 |
| abstract_inverted_index.that | 76, 134, 152, 163, 191 |
| abstract_inverted_index.were | 138 |
| abstract_inverted_index.with | 46, 155, 194 |
| abstract_inverted_index.(RIR) | 2 |
| abstract_inverted_index.Dicer | 137 |
| abstract_inverted_index.These | 188 |
| abstract_inverted_index.after | 39 |
| abstract_inverted_index.aimed | 15 |
| abstract_inverted_index.cells | 67 |
| abstract_inverted_index.drugs | 52, 82 |
| abstract_inverted_index.let-7 | 115, 135, 185 |
| abstract_inverted_index.nerve | 11, 208 |
| abstract_inverted_index.optic | 10, 207 |
| abstract_inverted_index.study | 14 |
| abstract_inverted_index.which | 105 |
| abstract_inverted_index.Dicer. | 123 |
| abstract_inverted_index.Lin28A | 101 |
| abstract_inverted_index.causes | 4 |
| abstract_inverted_index.cells. | 64 |
| abstract_inverted_index.drugs. | 148 |
| abstract_inverted_index.effect | 21, 78, 144, 162 |
| abstract_inverted_index.factor | 91 |
| abstract_inverted_index.family | 116 |
| abstract_inverted_index.injury | 3, 166 |
| abstract_inverted_index.layers | 71 |
| abstract_inverted_index.model. | 44 |
| abstract_inverted_index.option | 205 |
| abstract_inverted_index.output | 121 |
| abstract_inverted_index.visual | 169 |
| abstract_inverted_index.Lin28B, | 103 |
| abstract_inverted_index.Retinal | 0 |
| abstract_inverted_index.against | 26 |
| abstract_inverted_index.implied | 190 |
| abstract_inverted_index.induced | 97 |
| abstract_inverted_index.injury. | 28 |
| abstract_inverted_index.protein | 120 |
| abstract_inverted_index.reduced | 109 |
| abstract_inverted_index.retinal | 59, 62 |
| abstract_inverted_index.therapy | 154 |
| abstract_inverted_index.various | 9 |
| abstract_inverted_index.combined | 174 |
| abstract_inverted_index.feasible | 203 |
| abstract_inverted_index.findings | 150, 189 |
| abstract_inverted_index.ganglion | 63, 69 |
| abstract_inverted_index.neuronal | 5 |
| abstract_inverted_index.obtained | 126 |
| abstract_inverted_index.produced | 159 |
| abstract_inverted_index.provided | 176 |
| abstract_inverted_index.restored | 168 |
| abstract_inverted_index.resulted | 53, 106 |
| abstract_inverted_index.Apoptosis | 65 |
| abstract_inverted_index.Lin28A/B. | 187 |
| abstract_inverted_index.Treatment | 45 |
| abstract_inverted_index.addition, | 172 |
| abstract_inverted_index.diseases. | 12, 209 |
| abstract_inverted_index.function. | 170 |
| abstract_inverted_index.idebenone | 25, 34, 94, 158, 200 |
| abstract_inverted_index.increased | 119 |
| abstract_inverted_index.indicated | 133 |
| abstract_inverted_index.initiates | 8 |
| abstract_inverted_index.knockdown | 131 |
| abstract_inverted_index.microRNAs | 112 |
| abstract_inverted_index.necessary | 139 |
| abstract_inverted_index.selective | 182 |
| abstract_inverted_index.suggested | 151 |
| abstract_inverted_index.thickness | 60 |
| abstract_inverted_index.treatment | 175, 193, 204 |
| abstract_inverted_index.expression | 87, 99, 110 |
| abstract_inverted_index.increased. | 92 |
| abstract_inverted_index.rasagiline | 23, 32, 96, 156, 198 |
| abstract_inverted_index.regulation | 183 |
| abstract_inverted_index.suggesting | 75 |
| abstract_inverted_index.ameliorated | 164 |
| abstract_inverted_index.combination | 30, 48, 153, 196 |
| abstract_inverted_index.enhancement | 179 |
| abstract_inverted_index.experiments | 132 |
| abstract_inverted_index.immediately | 38 |
| abstract_inverted_index.investigate | 17 |
| abstract_inverted_index.restoration | 57 |
| abstract_inverted_index.significant | 56 |
| abstract_inverted_index.synergistic | 19, 84, 142, 161 |
| abstract_inverted_index.Furthermore, | 93 |
| abstract_inverted_index.administered | 36 |
| abstract_inverted_index.ameliorated, | 74 |
| abstract_inverted_index.degeneration | 6 |
| abstract_inverted_index.neurotrophic | 90 |
| abstract_inverted_index.brain-derived | 89 |
| abstract_inverted_index.establishment | 40 |
| abstract_inverted_index.respectively, | 104 |
| abstract_inverted_index.overexpression | 129 |
| abstract_inverted_index.neuroprotection | 177 |
| abstract_inverted_index.neuroprotective | 20, 143 |
| abstract_inverted_index.intraperitoneally | 37 |
| abstract_inverted_index.ischemia-reperfusion | 1 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 90 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8299999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.79758776 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |