Synergy of botanical drug extracts from Dracaena cochinchinensis stemwood and Ardisia elliptica fruit in multifunctional effects on neuroprotection and anti-inflammation Article Swipe
Dusadee Ospondpant
,
Queenie Wing Sze Lai
,
Tina Ting-Xia Dong
,
Karl Wah Keung Tsim
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2024.1399549
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2024.1399549
Combination therapy is one of the promising approaches in developing therapeutics to cure complex diseases, such as Alzheimer’s disease (AD). In Thai traditional medicines, the clinical application often comprises multiple botanical drugs as a formulation. The synergistic interactions between botanical drugs in combination therapies are proposed to have several advantages, including increased therapeutic efficacy, and decreased toxicity and/or adverse effects. This study aimed to explore the therapeutic functions of a botanical hybrid preparation (BHP) of two botanical drugs within a traditional multi-herbal formulation. The synergistic actions of BHP of Dracaena cochinchinensis stemwood (DCS) and Ardisia elliptica fruit (AEF) at a specific ratio of 1:9 w/w were illustrated in neuroprotection and anti-inflammation. In cultured PC12 cells, BHP of DCS and AEF showed synergistic functions in inducing neuronal differentiation, characterized by neurofilament expression and neurite outgrowth. In addition, BHP of DCS and AEF exhibited a synergistic effect in inhibiting the aggregation of Aβ, a hallmark of AD pathology. The activated BV2 microglial cells induced by LPS were synergistically suppressed by the BHP of DCS and AEF, as evaluated by the expression of pro-inflammatory markers, including TNF-α, IL-1β, and iNOS, as well as the morphological change of microglial cells. The findings suggested that the effects of BHP of DCS and AEF were greater than individual botanical drugs in a specific ratio of 1:9 w/w to enhance neuroprotective and anti-inflammatory functions.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fphar.2024.1399549
- OA Status
- gold
- Cited By
- 7
- References
- 25
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4396557673Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fphar.2024.1399549Digital Object Identifier
- Title
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Synergy of botanical drug extracts from Dracaena cochinchinensis stemwood and Ardisia elliptica fruit in multifunctional effects on neuroprotection and anti-inflammationWork title
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
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2024-05-01Full publication date if available
- Authors
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Dusadee Ospondpant, Queenie Wing Sze Lai, Tina Ting-Xia Dong, Karl Wah Keung TsimList of authors in order
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https://doi.org/10.3389/fphar.2024.1399549Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.3389/fphar.2024.1399549Direct OA link when available
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Neuroprotection, Pharmacology, Inflammation, Traditional medicine, Drug, Neurite, Medicine, Biology, Chemistry, Biochemistry, Immunology, In vitroTop concepts (fields/topics) attached by OpenAlex
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7Total citation count in OpenAlex
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2025: 6, 2024: 1Per-year citation counts (last 5 years)
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