Synthesis and Antimicrobial Activity of Chalcone-Derived 1,4-Dihydropyridine Derivatives Using Magnetic Fe2O3@SiO2 as Highly Efficient Nanocatalyst Article Swipe
Dharambeer Singh Malhi
,
Navneet Kaur
,
Manvinder Kaur
,
Haesook Han
,
Pradip K. Bhowmik
,
Fohad Mabood Husain
,
Harvinder Singh Sohal
,
Meenakshi Verma
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/catal15030281
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/catal15030281
The growing threat of bacterial resistance, coupled with the increasing costs associated with drug development, poses significant challenges in the discovery of new antibiotics. The present study reports the synthesis and antimicrobial evaluation of 1,4-dihydropyridine (1,4-DHP) derivatives derived from chalcones, using silica-mediated magnetic iron oxide, Fe2O3@SiO2 nanoparticles as a nanocatalyst. The nanoparticles were characterized using FT-IR, SEM-EDS, XRD, Zeta-Potential, and VSM techniques to confirm their structure and properties. Among them, the series 8a–e (particularly compound 8c) demonstrated strong antimicrobial activity, with effectiveness comparable to standard drugs Fluconazole and Amoxicillin; this was attributed to the presence of polar groups. Other derivatives exhibited moderate activity, with MICs ranging from 25 to 50 μg/mL, while no significant activity was observed against Gram-negative bacteria. These compounds hold potential as promising antimicrobial agents and warrant further investigation for the development of effective therapies.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/catal15030281
- https://www.mdpi.com/2073-4344/15/3/281/pdf?version=1742218272
- OA Status
- gold
- References
- 47
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408525440
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Raw OpenAlex JSON
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https://openalex.org/W4408525440Canonical identifier for this work in OpenAlex
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https://doi.org/10.3390/catal15030281Digital Object Identifier
- Title
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Synthesis and Antimicrobial Activity of Chalcone-Derived 1,4-Dihydropyridine Derivatives Using Magnetic Fe2O3@SiO2 as Highly Efficient NanocatalystWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-03-17Full publication date if available
- Authors
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Dharambeer Singh Malhi, Navneet Kaur, Manvinder Kaur, Haesook Han, Pradip K. Bhowmik, Fohad Mabood Husain, Harvinder Singh Sohal, Meenakshi VermaList of authors in order
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https://doi.org/10.3390/catal15030281Publisher landing page
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https://www.mdpi.com/2073-4344/15/3/281/pdf?version=1742218272Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2073-4344/15/3/281/pdf?version=1742218272Direct OA link when available
- Concepts
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Chalcone, Antimicrobial, Chemistry, Dihydropyridine, Combinatorial chemistry, Organic chemistry, CalciumTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| primary_location.landing_page_url | https://doi.org/10.3390/catal15030281 |
| publication_date | 2025-03-17 |
| publication_year | 2025 |
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