Synthesis and biological evaluation of rationally designed pyrazoles as insecticidal agents Article Swipe

PDF

Aroog Fatima , Samina Aslam , Sara Janiad , Shah Faisal , Ali Irfan , Javed Iqbal , Gamal A. Shazly , Ansa Madeeha Zafar , Aqeela Shaheen , Sobia Noreen , Emilio Mateev , Yousef A. Bin Jardan ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1007/s11030-024-11094-2

The current research focused on the synthesis of two series of pyrazole derivatives and evaluation of their insecticidal effectiveness. In the first series, seven pyrazole Schiff bases 3a-g were successfully synthesized with yields (79-95%) by condensing phenylfuran-2-carbaldehyde with substituted pyrazole rings. In the second series, eleven amino acid-pyrazole conjugates 6a-k were synthesized utilizing acetic acid, sulfuric acid, morpholine, and EDC. HCl achieving yields of 59% to 94%. The synthesized compounds were assessed for their chemotherapeutic efficacy against locusts and termites by calculating LC₅₀ values, thereby determining their potential as anti-termite and anti-locust agents. Among the eighteen synthesized pyrazole compounds, the Schiff base pyrazole molecules 3f (LC₅₀ = 0.001 μg/mL) and 3d (LC₅₀ = 0.006 μg/mL) demonstrated excellent anti-termite activity compared to the reference drug fipronil (LC₅₀ = 0.038 μg/mL). Pyrazole derivative 6 h with LC₅₀ = 47.68 μg/mL exhibited superior anti-locust activity than the reference drug fipronil (LC₅₀ = 63.09 μg/mL). Additionally, compound 3b, containing NO₂ functionality at the meta position, exhibited notable and significant anti-locust activity with an LC₅₀ values of 100.00 μg/mL. However, the highest mortality was caused by the glycine conjugate of fipronil 6 h of the 2nd series with an LC₅₀ value of 47.68 μg/mL, which also proved to be a potent anti-locust agent. This study explores the efficacy of biologically active pyrazole structures as potential insecticidal agents through a combination of virtual molecular docking analysis and biological experimental investigations. The results demonstrate a strong correlation between the computational predictions and experimental outcomes, suggesting that the pyrazole derivatives exhibit significant insecticidal properties. The findings highlight the potential of these compounds in the development of innovative insecticides, paving the way for future research in pest control strategies.

Related Topics

Chemistry

Computer Science

Engineering

Concepts

Combinatorial chemistry Biochemical engineering Chemistry Computer science Engineering

Metadata

Type: article
Language: en
Landing Page: https://doi.org/10.1007/s11030-024-11094-2
PDF: https://link.springer.com/content/pdf/10.1007/s11030-024-11094-2.pdf
OA Status: hybrid
Cited By: 6
References: 36
Related Works: 10
OpenAlex ID: https://openalex.org/W4406745482

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4406745482

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1007/s11030-024-11094-2

Digital Object Identifier
Title: Synthesis and biological evaluation of rationally designed pyrazoles as insecticidal agents

Work title
Type: article

OpenAlex work type
Language: en

Primary language
Publication year: 2025

Year of publication
Publication date: 2025-01-23

Full publication date if available
Authors: Aroog Fatima, Samina Aslam, Sara Janiad, Shah Faisal, Ali Irfan, Javed Iqbal, Gamal A. Shazly, Ansa Madeeha Zafar, Aqeela Shaheen, Sobia Noreen, Emilio Mateev, Yousef A. Bin Jardan

List of authors in order
Landing page: https://doi.org/10.1007/s11030-024-11094-2

Publisher landing page
PDF URL: https://link.springer.com/content/pdf/10.1007/s11030-024-11094-2.pdf

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: hybrid

Open access status per OpenAlex
OA URL: https://link.springer.com/content/pdf/10.1007/s11030-024-11094-2.pdf

Direct OA link when available
Concepts: Combinatorial chemistry, Biochemical engineering, Chemistry, Computer science, Engineering

Top concepts (fields/topics) attached by OpenAlex
Cited by: 6

Total citation count in OpenAlex
Citations by year (recent): 2025: 6

Per-year citation counts (last 5 years)
References (count): 36

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4406745482
doi	https://doi.org/10.1007/s11030-024-11094-2
ids.doi	https://doi.org/10.1007/s11030-024-11094-2
ids.pmid	https://pubmed.ncbi.nlm.nih.gov/39849238
ids.openalex	https://openalex.org/W4406745482
fwci	13.24270965
mesh[0].qualifier_ui	Q000138
mesh[0].descriptor_ui	D011720
mesh[0].is_major_topic	True
mesh[0].qualifier_name	chemical synthesis
mesh[0].descriptor_name	Pyrazoles
mesh[1].qualifier_ui	Q000737
mesh[1].descriptor_ui	D011720
mesh[1].is_major_topic	True
mesh[1].qualifier_name	chemistry
mesh[1].descriptor_name	Pyrazoles
mesh[2].qualifier_ui	Q000494
mesh[2].descriptor_ui	D011720
mesh[2].is_major_topic	True
mesh[2].qualifier_name	pharmacology
mesh[2].descriptor_name	Pyrazoles
mesh[3].qualifier_ui	Q000138
mesh[3].descriptor_ui	D007306
mesh[3].is_major_topic	True
mesh[3].qualifier_name	chemical synthesis
mesh[3].descriptor_name	Insecticides
mesh[4].qualifier_ui	Q000494
mesh[4].descriptor_ui	D007306
mesh[4].is_major_topic	True
mesh[4].qualifier_name	pharmacology
mesh[4].descriptor_name	Insecticides
mesh[5].qualifier_ui	Q000737
mesh[5].descriptor_ui	D007306
mesh[5].is_major_topic	True
mesh[5].qualifier_name	chemistry
mesh[5].descriptor_name	Insecticides
mesh[6].qualifier_ui
mesh[6].descriptor_ui	D000818
mesh[6].is_major_topic	False
mesh[6].qualifier_name
mesh[6].descriptor_name	Animals
mesh[7].qualifier_ui
mesh[7].descriptor_ui	D062105
mesh[7].is_major_topic	False
mesh[7].qualifier_name
mesh[7].descriptor_name	Molecular Docking Simulation
mesh[8].qualifier_ui
mesh[8].descriptor_ui	D015195
mesh[8].is_major_topic	True
mesh[8].qualifier_name
mesh[8].descriptor_name	Drug Design
mesh[9].qualifier_ui
mesh[9].descriptor_ui	D013329
mesh[9].is_major_topic	False
mesh[9].qualifier_name
mesh[9].descriptor_name	Structure-Activity Relationship
mesh[10].qualifier_ui	Q000187
mesh[10].descriptor_ui	D020049
mesh[10].is_major_topic	False
mesh[10].qualifier_name	drug effects
mesh[10].descriptor_name	Isoptera
mesh[11].qualifier_ui	Q000138
mesh[11].descriptor_ui	D011720
mesh[11].is_major_topic	True
mesh[11].qualifier_name	chemical synthesis
mesh[11].descriptor_name	Pyrazoles
mesh[12].qualifier_ui	Q000737
mesh[12].descriptor_ui	D011720
mesh[12].is_major_topic	True
mesh[12].qualifier_name	chemistry
mesh[12].descriptor_name	Pyrazoles
mesh[13].qualifier_ui	Q000494
mesh[13].descriptor_ui	D011720
mesh[13].is_major_topic	True
mesh[13].qualifier_name	pharmacology
mesh[13].descriptor_name	Pyrazoles
mesh[14].qualifier_ui	Q000138
mesh[14].descriptor_ui	D007306
mesh[14].is_major_topic	True
mesh[14].qualifier_name	chemical synthesis
mesh[14].descriptor_name	Insecticides
mesh[15].qualifier_ui	Q000494
mesh[15].descriptor_ui	D007306
mesh[15].is_major_topic	True
mesh[15].qualifier_name	pharmacology
mesh[15].descriptor_name	Insecticides
mesh[16].qualifier_ui	Q000737
mesh[16].descriptor_ui	D007306
mesh[16].is_major_topic	True
mesh[16].qualifier_name	chemistry
mesh[16].descriptor_name	Insecticides
mesh[17].qualifier_ui
mesh[17].descriptor_ui	D000818
mesh[17].is_major_topic	False
mesh[17].qualifier_name
mesh[17].descriptor_name	Animals
mesh[18].qualifier_ui
mesh[18].descriptor_ui	D062105
mesh[18].is_major_topic	False
mesh[18].qualifier_name
mesh[18].descriptor_name	Molecular Docking Simulation
mesh[19].qualifier_ui
mesh[19].descriptor_ui	D015195
mesh[19].is_major_topic	True
mesh[19].qualifier_name
mesh[19].descriptor_name	Drug Design
mesh[20].qualifier_ui
mesh[20].descriptor_ui	D013329
mesh[20].is_major_topic	False
mesh[20].qualifier_name
mesh[20].descriptor_name	Structure-Activity Relationship
mesh[21].qualifier_ui	Q000187
mesh[21].descriptor_ui	D020049
mesh[21].is_major_topic	False
mesh[21].qualifier_name	drug effects
mesh[21].descriptor_name	Isoptera
type	article
title	Synthesis and biological evaluation of rationally designed pyrazoles as insecticidal agents
awards[0].id	https://openalex.org/G683586371
awards[0].funder_id	https://openalex.org/F4320321145
awards[0].display_name
awards[0].funder_award_id	RSPD2025R1118
awards[0].funder_display_name	King Saud University
biblio.issue	6
biblio.volume	29
biblio.last_page	5792
biblio.first_page	5773
topics[0].id	https://openalex.org/T10274
topics[0].field.id	https://openalex.org/fields/16
topics[0].field.display_name	Chemistry
topics[0].score	0.9932000041007996
topics[0].domain.id	https://openalex.org/domains/3
topics[0].domain.display_name	Physical Sciences
topics[0].subfield.id	https://openalex.org/subfields/1605
topics[0].subfield.display_name	Organic Chemistry
topics[0].display_name	Synthesis and biological activity
topics[1].id	https://openalex.org/T10211
topics[1].field.id	https://openalex.org/fields/17
topics[1].field.display_name	Computer Science
topics[1].score	0.984000027179718
topics[1].domain.id	https://openalex.org/domains/3
topics[1].domain.display_name	Physical Sciences
topics[1].subfield.id	https://openalex.org/subfields/1703
topics[1].subfield.display_name	Computational Theory and Mathematics
topics[1].display_name	Computational Drug Discovery Methods
topics[2].id	https://openalex.org/T11900
topics[2].field.id	https://openalex.org/fields/11
topics[2].field.display_name	Agricultural and Biological Sciences
topics[2].score	0.9811000227928162
topics[2].domain.id	https://openalex.org/domains/1
topics[2].domain.display_name	Life Sciences
topics[2].subfield.id	https://openalex.org/subfields/1105
topics[2].subfield.display_name	Ecology, Evolution, Behavior and Systematics
topics[2].display_name	Fungal Plant Pathogen Control
funders[0].id	https://openalex.org/F4320321145
funders[0].ror	https://ror.org/02f81g417
funders[0].display_name	King Saud University
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C21951064
concepts[0].level	1
concepts[0].score	0.5795005559921265
concepts[0].wikidata	https://www.wikidata.org/wiki/Q899212
concepts[0].display_name	Combinatorial chemistry
concepts[1].id	https://openalex.org/C183696295
concepts[1].level	1
concepts[1].score	0.4538766145706177
concepts[1].wikidata	https://www.wikidata.org/wiki/Q2487696
concepts[1].display_name	Biochemical engineering
concepts[2].id	https://openalex.org/C185592680
concepts[2].level	0
concepts[2].score	0.38971641659736633
concepts[2].wikidata	https://www.wikidata.org/wiki/Q2329
concepts[2].display_name	Chemistry
concepts[3].id	https://openalex.org/C41008148
concepts[3].level	0
concepts[3].score	0.3455308973789215
concepts[3].wikidata	https://www.wikidata.org/wiki/Q21198
concepts[3].display_name	Computer science
concepts[4].id	https://openalex.org/C127413603
concepts[4].level	0
concepts[4].score	0.19111835956573486
concepts[4].wikidata	https://www.wikidata.org/wiki/Q11023
concepts[4].display_name	Engineering
keywords[0].id	https://openalex.org/keywords/combinatorial-chemistry
keywords[0].score	0.5795005559921265
keywords[0].display_name	Combinatorial chemistry
keywords[1].id	https://openalex.org/keywords/biochemical-engineering
keywords[1].score	0.4538766145706177
keywords[1].display_name	Biochemical engineering
keywords[2].id	https://openalex.org/keywords/chemistry
keywords[2].score	0.38971641659736633
keywords[2].display_name	Chemistry
keywords[3].id	https://openalex.org/keywords/computer-science
keywords[3].score	0.3455308973789215
keywords[3].display_name	Computer science
keywords[4].id	https://openalex.org/keywords/engineering
keywords[4].score	0.19111835956573486
keywords[4].display_name	Engineering
language	en
locations[0].id	doi:10.1007/s11030-024-11094-2
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S105791650
locations[0].source.issn	1381-1991, 1573-501X
locations[0].source.type	journal
locations[0].source.is_oa	False
locations[0].source.issn_l	1381-1991
locations[0].source.is_core	True
locations[0].source.is_in_doaj	False
locations[0].source.display_name	Molecular Diversity
locations[0].source.host_organization	https://openalex.org/P4310319900
locations[0].source.host_organization_name	Springer Science+Business Media
locations[0].source.host_organization_lineage	https://openalex.org/P4310319900, https://openalex.org/P4310319965
locations[0].source.host_organization_lineage_names	Springer Science+Business Media, Springer Nature
locations[0].license	cc-by-nc-nd
locations[0].pdf_url	https://link.springer.com/content/pdf/10.1007/s11030-024-11094-2.pdf
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id	https://openalex.org/licenses/cc-by-nc-nd
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	Molecular Diversity
locations[0].landing_page_url	https://doi.org/10.1007/s11030-024-11094-2
locations[1].id	pmid:39849238
locations[1].is_oa	False
locations[1].source.id	https://openalex.org/S4306525036
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	PubMed
locations[1].source.host_organization	https://openalex.org/I1299303238
locations[1].source.host_organization_name	National Institutes of Health
locations[1].source.host_organization_lineage	https://openalex.org/I1299303238
locations[1].license
locations[1].pdf_url
locations[1].version	publishedVersion
locations[1].raw_type
locations[1].license_id
locations[1].is_accepted	True
locations[1].is_published	True
locations[1].raw_source_name	Molecular diversity
locations[1].landing_page_url	https://pubmed.ncbi.nlm.nih.gov/39849238
locations[2].id	pmh:oai:europepmc.org:11445246
locations[2].is_oa	True
locations[2].source.id	https://openalex.org/S4306400806
locations[2].source.issn
locations[2].source.type	repository
locations[2].source.is_oa	False
locations[2].source.issn_l
locations[2].source.is_core	False
locations[2].source.is_in_doaj	False
locations[2].source.display_name	Europe PMC (PubMed Central)
locations[2].source.host_organization	https://openalex.org/I1303153112
locations[2].source.host_organization_name	European Bioinformatics Institute
locations[2].source.host_organization_lineage	https://openalex.org/I1303153112
locations[2].license	other-oa
locations[2].pdf_url
locations[2].version	submittedVersion
locations[2].raw_type	Text
locations[2].license_id	https://openalex.org/licenses/other-oa
locations[2].is_accepted	False
locations[2].is_published	False
locations[2].raw_source_name
locations[2].landing_page_url	https://www.ncbi.nlm.nih.gov/pmc/articles/12638334
indexed_in	crossref, pubmed
authorships[0].author.id	https://openalex.org/A5088049634
authorships[0].author.orcid
authorships[0].author.display_name	Aroog Fatima
authorships[0].countries	PK
authorships[0].affiliations[0].institution_ids	https://openalex.org/I4210126226
authorships[0].affiliations[0].raw_affiliation_string	Department of Chemistry, The Women University Multan, Multan, 2023, Pakistan
authorships[0].institutions[0].id	https://openalex.org/I4210126226
authorships[0].institutions[0].ror	https://ror.org/035ggvj17
authorships[0].institutions[0].type	education
authorships[0].institutions[0].lineage	https://openalex.org/I4210126226
authorships[0].institutions[0].country_code	PK
authorships[0].institutions[0].display_name	The Women University Multan
authorships[0].author_position	first
authorships[0].raw_author_name	Aroog Fatima
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	Department of Chemistry, The Women University Multan, Multan, 2023, Pakistan
authorships[1].author.id	https://openalex.org/A5088192350
authorships[1].author.orcid	https://orcid.org/0000-0001-8902-9376
authorships[1].author.display_name	Samina Aslam
authorships[1].countries	PK
authorships[1].affiliations[0].institution_ids	https://openalex.org/I4210126226
authorships[1].affiliations[0].raw_affiliation_string	Department of Chemistry, The Women University Multan, Multan, 2023, Pakistan
authorships[1].institutions[0].id	https://openalex.org/I4210126226
authorships[1].institutions[0].ror	https://ror.org/035ggvj17
authorships[1].institutions[0].type	education
authorships[1].institutions[0].lineage	https://openalex.org/I4210126226
authorships[1].institutions[0].country_code	PK
authorships[1].institutions[0].display_name	The Women University Multan
authorships[1].author_position	middle
authorships[1].raw_author_name	Samina Aslam
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	Department of Chemistry, The Women University Multan, Multan, 2023, Pakistan
authorships[2].author.id	https://openalex.org/A5116000674
authorships[2].author.orcid
authorships[2].author.display_name	Sara Janiad
authorships[2].countries	PK
authorships[2].affiliations[0].institution_ids	https://openalex.org/I4210126226
authorships[2].affiliations[0].raw_affiliation_string	Department of Microbiology and Molecular Genetics, The Women University Multan, Multan, 2023, Pakistan
authorships[2].institutions[0].id	https://openalex.org/I4210126226
authorships[2].institutions[0].ror	https://ror.org/035ggvj17
authorships[2].institutions[0].type	education
authorships[2].institutions[0].lineage	https://openalex.org/I4210126226
authorships[2].institutions[0].country_code	PK
authorships[2].institutions[0].display_name	The Women University Multan
authorships[2].author_position	middle
authorships[2].raw_author_name	Sara Janiad
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	Department of Microbiology and Molecular Genetics, The Women University Multan, Multan, 2023, Pakistan
authorships[3].author.id	https://openalex.org/A5012584451
authorships[3].author.orcid	https://orcid.org/0000-0002-5105-6982
authorships[3].author.display_name	Shah Faisal
authorships[3].countries	PK
authorships[3].affiliations[0].institution_ids	https://openalex.org/I206573129
authorships[3].affiliations[0].raw_affiliation_string	Department of Chemistry, Islamia College University Peshawar, Peshawar, 25120, Pakistan
authorships[3].institutions[0].id	https://openalex.org/I206573129
authorships[3].institutions[0].ror	https://ror.org/02p2c1595
authorships[3].institutions[0].type	education
authorships[3].institutions[0].lineage	https://openalex.org/I206573129
authorships[3].institutions[0].country_code	PK
authorships[3].institutions[0].display_name	Islamia College University
authorships[3].author_position	middle
authorships[3].raw_author_name	Shah Faisal
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	Department of Chemistry, Islamia College University Peshawar, Peshawar, 25120, Pakistan
authorships[4].author.id	https://openalex.org/A5010528666
authorships[4].author.orcid	https://orcid.org/0000-0002-8977-3303
authorships[4].author.display_name	Ali Irfan
authorships[4].countries	PK
authorships[4].affiliations[0].institution_ids	https://openalex.org/I194348271
authorships[4].affiliations[0].raw_affiliation_string	Department of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan
authorships[4].institutions[0].id	https://openalex.org/I194348271
authorships[4].institutions[0].ror	https://ror.org/051zgra59
authorships[4].institutions[0].type	education
authorships[4].institutions[0].lineage	https://openalex.org/I194348271
authorships[4].institutions[0].country_code	PK
authorships[4].institutions[0].display_name	Government College University, Faisalabad
authorships[4].author_position	middle
authorships[4].raw_author_name	Ali Irfan
authorships[4].is_corresponding	True
authorships[4].raw_affiliation_strings	Department of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan
authorships[5].author.id	https://openalex.org/A5070616634
authorships[5].author.orcid	https://orcid.org/0000-0002-4520-7721
authorships[5].author.display_name	Javed Iqbal
authorships[5].countries	PK
authorships[5].affiliations[0].institution_ids	https://openalex.org/I4210102737
authorships[5].affiliations[0].raw_affiliation_string	Department of Agricultural Engineering, Khwaja Fareed University of Engineering and Information Technology (KFUEIT), Rahim Yar Khan, 64200, Pakistan
authorships[5].institutions[0].id	https://openalex.org/I4210102737
authorships[5].institutions[0].ror	https://ror.org/0161dyt30
authorships[5].institutions[0].type	education
authorships[5].institutions[0].lineage	https://openalex.org/I4210102737
authorships[5].institutions[0].country_code	PK
authorships[5].institutions[0].display_name	Khwaja Fareed University of Engineering and Information Technology
authorships[5].author_position	middle
authorships[5].raw_author_name	Javed Iqbal
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	Department of Agricultural Engineering, Khwaja Fareed University of Engineering and Information Technology (KFUEIT), Rahim Yar Khan, 64200, Pakistan
authorships[6].author.id	https://openalex.org/A5065900864
authorships[6].author.orcid	https://orcid.org/0000-0002-1291-2088
authorships[6].author.display_name	Gamal A. Shazly
authorships[6].countries	SA
authorships[6].affiliations[0].institution_ids	https://openalex.org/I28022161
authorships[6].affiliations[0].raw_affiliation_string	Department of Pharmaceutics, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia
authorships[6].institutions[0].id	https://openalex.org/I28022161
authorships[6].institutions[0].ror	https://ror.org/02f81g417
authorships[6].institutions[0].type	education
authorships[6].institutions[0].lineage	https://openalex.org/I28022161
authorships[6].institutions[0].country_code	SA
authorships[6].institutions[0].display_name	King Saud University
authorships[6].author_position	middle
authorships[6].raw_author_name	Gamal A. Shazly
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	Department of Pharmaceutics, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia
authorships[7].author.id	https://openalex.org/A5040259913
authorships[7].author.orcid	https://orcid.org/0000-0001-6277-6486
authorships[7].author.display_name	Ansa Madeeha Zafar
authorships[7].countries	PK
authorships[7].affiliations[0].institution_ids	https://openalex.org/I2800060998
authorships[7].affiliations[0].raw_affiliation_string	Department of Chemistry, Government Sadiq College Women University, Bahawalpur, 63100, Pakistan
authorships[7].institutions[0].id	https://openalex.org/I2800060998
authorships[7].institutions[0].ror	https://ror.org/01zp49f50
authorships[7].institutions[0].type	education
authorships[7].institutions[0].lineage	https://openalex.org/I2800060998
authorships[7].institutions[0].country_code	PK
authorships[7].institutions[0].display_name	Government Sadiq College Women University
authorships[7].author_position	middle
authorships[7].raw_author_name	Ansa Madeeha Zafar
authorships[7].is_corresponding	False
authorships[7].raw_affiliation_strings	Department of Chemistry, Government Sadiq College Women University, Bahawalpur, 63100, Pakistan
authorships[8].author.id	https://openalex.org/A5112562998
authorships[8].author.orcid
authorships[8].author.display_name	Aqeela Shaheen
authorships[8].countries	PK
authorships[8].affiliations[0].institution_ids	https://openalex.org/I2800060998
authorships[8].affiliations[0].raw_affiliation_string	Department of Chemistry, Government Sadiq College Women University, Bahawalpur, 63100, Pakistan
authorships[8].institutions[0].id	https://openalex.org/I2800060998
authorships[8].institutions[0].ror	https://ror.org/01zp49f50
authorships[8].institutions[0].type	education
authorships[8].institutions[0].lineage	https://openalex.org/I2800060998
authorships[8].institutions[0].country_code	PK
authorships[8].institutions[0].display_name	Government Sadiq College Women University
authorships[8].author_position	middle
authorships[8].raw_author_name	Aqeela Shaheen
authorships[8].is_corresponding	False
authorships[8].raw_affiliation_strings	Department of Chemistry, Government Sadiq College Women University, Bahawalpur, 63100, Pakistan
authorships[9].author.id	https://openalex.org/A5052159031
authorships[9].author.orcid	https://orcid.org/0000-0002-0815-2223
authorships[9].author.display_name	Sobia Noreen
authorships[9].countries	PK
authorships[9].affiliations[0].institution_ids	https://openalex.org/I160968435
authorships[9].affiliations[0].raw_affiliation_string	Institute of Chemistry, University of Sargodha, Sargodha, 40100, Pakistan
authorships[9].institutions[0].id	https://openalex.org/I160968435
authorships[9].institutions[0].ror	https://ror.org/0086rpr26
authorships[9].institutions[0].type	education
authorships[9].institutions[0].lineage	https://openalex.org/I160968435
authorships[9].institutions[0].country_code	PK
authorships[9].institutions[0].display_name	University of Sargodha
authorships[9].author_position	middle
authorships[9].raw_author_name	Sobia Noreen
authorships[9].is_corresponding	False
authorships[9].raw_affiliation_strings	Institute of Chemistry, University of Sargodha, Sargodha, 40100, Pakistan
authorships[10].author.id	https://openalex.org/A5011166542
authorships[10].author.orcid	https://orcid.org/0000-0002-5885-7213
authorships[10].author.display_name	Emilio Mateev
authorships[10].countries	BG
authorships[10].affiliations[0].institution_ids	https://openalex.org/I30147112
authorships[10].affiliations[0].raw_affiliation_string	Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University, Sofia, Bulgaria
authorships[10].institutions[0].id	https://openalex.org/I30147112
authorships[10].institutions[0].ror	https://ror.org/01n9zy652
authorships[10].institutions[0].type	education
authorships[10].institutions[0].lineage	https://openalex.org/I30147112
authorships[10].institutions[0].country_code	BG
authorships[10].institutions[0].display_name	Medical University of Sofia
authorships[10].author_position	middle
authorships[10].raw_author_name	Emilio Mateev
authorships[10].is_corresponding	False
authorships[10].raw_affiliation_strings	Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University, Sofia, Bulgaria
authorships[11].author.id	https://openalex.org/A5031834080
authorships[11].author.orcid	https://orcid.org/0000-0003-3302-4036
authorships[11].author.display_name	Yousef A. Bin Jardan
authorships[11].countries	SA
authorships[11].affiliations[0].institution_ids	https://openalex.org/I28022161
authorships[11].affiliations[0].raw_affiliation_string	Department of Pharmaceutics, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia
authorships[11].institutions[0].id	https://openalex.org/I28022161
authorships[11].institutions[0].ror	https://ror.org/02f81g417
authorships[11].institutions[0].type	education
authorships[11].institutions[0].lineage	https://openalex.org/I28022161
authorships[11].institutions[0].country_code	SA
authorships[11].institutions[0].display_name	King Saud University
authorships[11].author_position	last
authorships[11].raw_author_name	Yousef A. Bin Jardan
authorships[11].is_corresponding	False
authorships[11].raw_affiliation_strings	Department of Pharmaceutics, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia
has_content.pdf	True
has_content.grobid_xml	True
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://link.springer.com/content/pdf/10.1007/s11030-024-11094-2.pdf
open_access.oa_status	hybrid
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Synthesis and biological evaluation of rationally designed pyrazoles as insecticidal agents
has_fulltext	True
is_retracted	False
updated_date	2025-11-23T05:10:03.516525
primary_topic.id	https://openalex.org/T10274
primary_topic.field.id	https://openalex.org/fields/16
primary_topic.field.display_name	Chemistry
primary_topic.score	0.9932000041007996
primary_topic.domain.id	https://openalex.org/domains/3
primary_topic.domain.display_name	Physical Sciences
primary_topic.subfield.id	https://openalex.org/subfields/1605
primary_topic.subfield.display_name	Organic Chemistry
primary_topic.display_name	Synthesis and biological activity
related_works	https://openalex.org/W4387497383, https://openalex.org/W2948807893, https://openalex.org/W2899084033, https://openalex.org/W2778153218, https://openalex.org/W2748952813, https://openalex.org/W1531601525, https://openalex.org/W4391375266, https://openalex.org/W2078814861, https://openalex.org/W2527526854, https://openalex.org/W1976181487
cited_by_count	6
counts_by_year[0].year	2025
counts_by_year[0].cited_by_count	6
locations_count	3
best_oa_location.id	doi:10.1007/s11030-024-11094-2
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S105791650
best_oa_location.source.issn	1381-1991, 1573-501X
best_oa_location.source.type	journal
best_oa_location.source.is_oa	False
best_oa_location.source.issn_l	1381-1991
best_oa_location.source.is_core	True
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	Molecular Diversity
best_oa_location.source.host_organization	https://openalex.org/P4310319900
best_oa_location.source.host_organization_name	Springer Science+Business Media
best_oa_location.source.host_organization_lineage	https://openalex.org/P4310319900, https://openalex.org/P4310319965
best_oa_location.source.host_organization_lineage_names	Springer Science+Business Media, Springer Nature
best_oa_location.license	cc-by-nc-nd
best_oa_location.pdf_url	https://link.springer.com/content/pdf/10.1007/s11030-024-11094-2.pdf
best_oa_location.version	publishedVersion
best_oa_location.raw_type	journal-article
best_oa_location.license_id	https://openalex.org/licenses/cc-by-nc-nd
best_oa_location.is_accepted	True
best_oa_location.is_published	True
best_oa_location.raw_source_name	Molecular Diversity
best_oa_location.landing_page_url	https://doi.org/10.1007/s11030-024-11094-2
primary_location.id	doi:10.1007/s11030-024-11094-2
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S105791650
primary_location.source.issn	1381-1991, 1573-501X
primary_location.source.type	journal
primary_location.source.is_oa	False
primary_location.source.issn_l	1381-1991
primary_location.source.is_core	True
primary_location.source.is_in_doaj	False
primary_location.source.display_name	Molecular Diversity
primary_location.source.host_organization	https://openalex.org/P4310319900
primary_location.source.host_organization_name	Springer Science+Business Media
primary_location.source.host_organization_lineage	https://openalex.org/P4310319900, https://openalex.org/P4310319965
primary_location.source.host_organization_lineage_names	Springer Science+Business Media, Springer Nature
primary_location.license	cc-by-nc-nd
primary_location.pdf_url	https://link.springer.com/content/pdf/10.1007/s11030-024-11094-2.pdf
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id	https://openalex.org/licenses/cc-by-nc-nd
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	Molecular Diversity
primary_location.landing_page_url	https://doi.org/10.1007/s11030-024-11094-2
publication_date	2025-01-23
publication_year	2025
referenced_works	https://openalex.org/W2969031962, https://openalex.org/W955006108, https://openalex.org/W3085225911, https://openalex.org/W1970995802, https://openalex.org/W2066014580, https://openalex.org/W3000158978, https://openalex.org/W2568761365, https://openalex.org/W2064460437, https://openalex.org/W4229444754, https://openalex.org/W3173575018, https://openalex.org/W2622043758, https://openalex.org/W3081311712, https://openalex.org/W2061465090, https://openalex.org/W1867233816, https://openalex.org/W2040129095, https://openalex.org/W2972682363, https://openalex.org/W3164571468, https://openalex.org/W1986842837, https://openalex.org/W1600247354, https://openalex.org/W3045228316, https://openalex.org/W4206617617, https://openalex.org/W3107032160, https://openalex.org/W2987160832, https://openalex.org/W2334737408, https://openalex.org/W2034013560, https://openalex.org/W2950935132, https://openalex.org/W2804822363, https://openalex.org/W2134967712, https://openalex.org/W3168436232, https://openalex.org/W6817391364, https://openalex.org/W4239761798, https://openalex.org/W2801057074, https://openalex.org/W3040888400, https://openalex.org/W2097982654, https://openalex.org/W3011073742, https://openalex.org/W4234088793
referenced_works_count	36
abstract_inverted_index.6	131, 186
abstract_inverted_index.=	106, 112, 126, 135, 148
abstract_inverted_index.a	204, 223, 237
abstract_inverted_index.h	132, 187
abstract_inverted_index.3d	110
abstract_inverted_index.3f	104
abstract_inverted_index.In	19, 41
abstract_inverted_index.an	168, 193
abstract_inverted_index.as	88, 218
abstract_inverted_index.at	157
abstract_inverted_index.be	203
abstract_inverted_index.by	34, 80, 180
abstract_inverted_index.in	264, 276
abstract_inverted_index.of	7, 10, 15, 63, 171, 184, 188, 196, 213, 225, 261, 267
abstract_inverted_index.on	4
abstract_inverted_index.to	65, 120, 202
abstract_inverted_index.2nd	190
abstract_inverted_index.3b,	153
abstract_inverted_index.59%	64
abstract_inverted_index.HCl	60
abstract_inverted_index.The	0, 67, 234, 256
abstract_inverted_index.and	13, 58, 78, 90, 109, 163, 230, 244
abstract_inverted_index.for	72, 273
abstract_inverted_index.the	5, 20, 42, 94, 99, 121, 143, 158, 175, 181, 189, 211, 241, 249, 259, 265, 271
abstract_inverted_index.two	8
abstract_inverted_index.was	178
abstract_inverted_index.way	272
abstract_inverted_index.3a-g	27
abstract_inverted_index.6a-k	49
abstract_inverted_index.94%.	66
abstract_inverted_index.EDC.	59
abstract_inverted_index.This	208
abstract_inverted_index.also	200
abstract_inverted_index.base	101
abstract_inverted_index.drug	123, 145
abstract_inverted_index.meta	159
abstract_inverted_index.pest	277
abstract_inverted_index.than	142
abstract_inverted_index.that	248
abstract_inverted_index.were	28, 50, 70
abstract_inverted_index.with	31, 37, 133, 167, 192
abstract_inverted_index.0.001	107
abstract_inverted_index.0.006	113
abstract_inverted_index.0.038	127
abstract_inverted_index.47.68	136, 197
abstract_inverted_index.63.09	149
abstract_inverted_index.Among	93
abstract_inverted_index.acid,	54, 56
abstract_inverted_index.amino	46
abstract_inverted_index.bases	26
abstract_inverted_index.first	21
abstract_inverted_index.seven	23
abstract_inverted_index.study	209
abstract_inverted_index.their	16, 73, 86
abstract_inverted_index.these	262
abstract_inverted_index.value	195
abstract_inverted_index.which	199
abstract_inverted_index.100.00	172
abstract_inverted_index.Schiff	25, 100
abstract_inverted_index.acetic	53
abstract_inverted_index.active	215
abstract_inverted_index.agent.	207
abstract_inverted_index.agents	221
abstract_inverted_index.caused	179
abstract_inverted_index.eleven	45
abstract_inverted_index.future	274
abstract_inverted_index.paving	270
abstract_inverted_index.potent	205
abstract_inverted_index.proved	201
abstract_inverted_index.rings.	40
abstract_inverted_index.second	43
abstract_inverted_index.series	9, 191
abstract_inverted_index.strong	238
abstract_inverted_index.values	170
abstract_inverted_index.yields	32, 62
abstract_inverted_index.μg/mL	137
abstract_inverted_index.against	76
abstract_inverted_index.agents.	92
abstract_inverted_index.between	240
abstract_inverted_index.control	278
abstract_inverted_index.current	1
abstract_inverted_index.docking	228
abstract_inverted_index.exhibit	252
abstract_inverted_index.focused	3
abstract_inverted_index.glycine	182
abstract_inverted_index.highest	176
abstract_inverted_index.locusts	77
abstract_inverted_index.notable	162
abstract_inverted_index.results	235
abstract_inverted_index.series,	22, 44
abstract_inverted_index.thereby	84
abstract_inverted_index.through	222
abstract_inverted_index.values,	83
abstract_inverted_index.virtual	226
abstract_inverted_index.μg/mL)	108, 114
abstract_inverted_index.μg/mL,	198
abstract_inverted_index.μg/mL.	173
abstract_inverted_index.(79-95%)	33
abstract_inverted_index.However,	174
abstract_inverted_index.Pyrazole	129
abstract_inverted_index.activity	118, 141, 166
abstract_inverted_index.analysis	229
abstract_inverted_index.assessed	71
abstract_inverted_index.compared	119
abstract_inverted_index.compound	152
abstract_inverted_index.efficacy	75, 212
abstract_inverted_index.eighteen	95
abstract_inverted_index.explores	210
abstract_inverted_index.findings	257
abstract_inverted_index.fipronil	124, 146, 185
abstract_inverted_index.pyrazole	11, 24, 39, 97, 102, 216, 250
abstract_inverted_index.research	2, 275
abstract_inverted_index.sulfuric	55
abstract_inverted_index.superior	139
abstract_inverted_index.termites	79
abstract_inverted_index.μg/mL).	128, 150
abstract_inverted_index.achieving	61
abstract_inverted_index.compounds	69, 263
abstract_inverted_index.conjugate	183
abstract_inverted_index.excellent	116
abstract_inverted_index.exhibited	138, 161
abstract_inverted_index.highlight	258
abstract_inverted_index.molecular	227
abstract_inverted_index.molecules	103
abstract_inverted_index.mortality	177
abstract_inverted_index.outcomes,	246
abstract_inverted_index.position,	160
abstract_inverted_index.potential	87, 219, 260
abstract_inverted_index.reference	122, 144
abstract_inverted_index.synthesis	6
abstract_inverted_index.utilizing	52
abstract_inverted_index.biological	231
abstract_inverted_index.compounds,	98
abstract_inverted_index.condensing	35
abstract_inverted_index.conjugates	48
abstract_inverted_index.containing	154
abstract_inverted_index.derivative	130
abstract_inverted_index.evaluation	14
abstract_inverted_index.innovative	268
abstract_inverted_index.structures	217
abstract_inverted_index.suggesting	247
abstract_inverted_index.anti-locust	91, 140, 165, 206
abstract_inverted_index.calculating	81
abstract_inverted_index.combination	224
abstract_inverted_index.correlation	239
abstract_inverted_index.demonstrate	236
abstract_inverted_index.derivatives	12, 251
abstract_inverted_index.determining	85
abstract_inverted_index.development	266
abstract_inverted_index.morpholine,	57
abstract_inverted_index.predictions	243
abstract_inverted_index.properties.	255
abstract_inverted_index.significant	164, 253
abstract_inverted_index.strategies.	279
abstract_inverted_index.substituted	38
abstract_inverted_index.synthesized	30, 51, 68, 96
abstract_inverted_index.anti-termite	89, 117
abstract_inverted_index.biologically	214
abstract_inverted_index.demonstrated	115
abstract_inverted_index.experimental	232, 245
abstract_inverted_index.insecticidal	17, 220, 254
abstract_inverted_index.successfully	29
abstract_inverted_index.Additionally,	151
abstract_inverted_index.acid-pyrazole	47
abstract_inverted_index.computational	242
abstract_inverted_index.functionality	156
abstract_inverted_index.insecticides,	269
abstract_inverted_index.NO<sub>2</sub>	155
abstract_inverted_index.effectiveness.	18
abstract_inverted_index.LC<sub>50</sub>	82, 134, 169, 194
abstract_inverted_index.investigations.	233
abstract_inverted_index.(LC<sub>50</sub>	105, 111, 125, 147
abstract_inverted_index.chemotherapeutic	74
abstract_inverted_index.phenylfuran-2-carbaldehyde	36
cited_by_percentile_year.max	99
cited_by_percentile_year.min	98
corresponding_author_ids	https://openalex.org/A5010528666
countries_distinct_count	3
institutions_distinct_count	12
corresponding_institution_ids	https://openalex.org/I194348271
sustainable_development_goals[0].id	https://metadata.un.org/sdg/2
sustainable_development_goals[0].score	0.5400000214576721
sustainable_development_goals[0].display_name	Zero hunger
citation_normalized_percentile.value	0.97351596
citation_normalized_percentile.is_in_top_1_percent	True
citation_normalized_percentile.is_in_top_10_percent	True