Synthesis and cytotoxicity evaluation of novel cyclic/non-cyclic N-aryl enamino amides against human cancer cell lines Article Swipe
Shahab Bohlooli
,
Negin Nejatkhah
,
Saghi Sepehri
,
Donya Doostkamel
,
Nima Razzaghi‐Asl
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.4103/1735-5362.301341
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.4103/1735-5362.301341
DHPMTs were better cytotoxic agents than non-cyclic enamino amides. Structure activity relationship studies guided us toward the design of DHPMT derivatives with OH and NH groups particularly on meta position of 4-phenyl ring and hydrophobic bulky substituents on carboxamide side chain within the structure. Possible interaction with the hydrophobic site(s) of the cellular target was supposed. The results of this study emphasized the potential role of DHPMTs and their optimized derivatives as privileged medicinal scaffolds to inhibit the growth of gastric, breast, and liver cancer cells.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4103/1735-5362.301341
- OA Status
- gold
- Cited By
- 4
- References
- 16
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3110544344
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3110544344Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.4103/1735-5362.301341Digital Object Identifier
- Title
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Synthesis and cytotoxicity evaluation of novel cyclic/non-cyclic N-aryl enamino amides against human cancer cell linesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-01-01Full publication date if available
- Authors
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Shahab Bohlooli, Negin Nejatkhah, Saghi Sepehri, Donya Doostkamel, Nima Razzaghi‐AslList of authors in order
- Landing page
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https://doi.org/10.4103/1735-5362.301341Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.4103/1735-5362.301341Direct OA link when available
- Concepts
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Cytotoxicity, Chemistry, Stereochemistry, IC50, Aryl, Cytotoxic T cell, Hep G2, Cancer cell, Growth inhibition, Cell growth, Cell culture, Carboxamide, Cancer cell lines, In vitro, Combinatorial chemistry, Cancer, Biochemistry, Organic chemistry, Biology, Medicine, Internal medicine, Genetics, AlkylTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 2, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
16Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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