Synthesis and evaluation of isothiazolo[4,5-b]pyridines as cyclin G-associated kinase (GAK) inhibitors Article Swipe
Related Concepts
In silico
Kinase
Chemistry
Cyclin
Stereochemistry
Biochemistry
Cell cycle
Cell
Gene
Yulia Ivanova
,
Sander Spittaels
,
Ling‐Jie Gao
,
Dominique Schols
,
Luc Van Meervelt
,
Matheus Froeyen
,
Wim Dehaen
,
Steven De Jonghe
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1039/d4ob00908h
· OA: W4401738706
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1039/d4ob00908h
· OA: W4401738706
A novel route to various substituted isothiazolo[4,5- b ]pyridines was established. The compounds completely lacked GAK affinity, which was explained by in silico analysis.
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