Synthesis and evaluation of radiogallium-labeled long-chain fatty acid derivatives as myocardial metabolic imaging agents Article Swipe
Nurmaya Effendi
,
Kenji Mishiro
,
Hiroshi Wakabayashi
,
Malwina Gabryel-Skrodzka
,
Kazuhiro Shiba
,
Junichi Taki
,
Renata Jastrząb
,
Seigo Kinuya
,
Kazuma Ogawa
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0261226
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0261226
Since long-chain fatty acids work as the primary energy source for the myocardium, radiolabeled long-chain fatty acids play an important role as imaging agents to diagnose metabolic heart dysfunction and heart diseases. With the aim of developing radiogallium-labeled fatty acids, herein four fatty acid-based tracers, [ 67 Ga]Ga-HBED-CC-PDA, [ 67 Ga]Ga-HBED-CC-MHDA, [ 67 Ga]Ga-DOTA-PDA, and [ 67 Ga]Ga-DOTA-MHDA, which are [ 67 Ga]Ga-HBED-CC and [ 67 Ga]Ga-DOTA conjugated with pentadecanoic acid (PDA) and 3-methylhexadecanoic acid (MHDA), were synthesized, and their potential for myocardial metabolic imaging was evaluated. Those tracers were found to be chemically stable in 0.1 M phosphate buffered saline. Initial [ 67 Ga]Ga-HBED-CC-PDA, [ 67 Ga]Ga-HBED-CC-MHDA, [ 67 Ga]Ga-DOTA-PDA, and [ 67 Ga]Ga-DOTA-MHDA uptakes in the heart at 0.5 min postinjection were 5.01 ± 0.30%ID/g, 5.74 ± 1.02%ID/g, 5.67 ± 0.22%ID/g, and 5.29 ± 0.10%ID/g, respectively. These values were significantly lower than that of [ 123 I]BMIPP (21.36 ± 2.73%ID/g). For their clinical application as myocardial metabolic imaging agents, further structural modifications are required to increase their uptake in the heart.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0261226
- OA Status
- gold
- Cited By
- 3
- References
- 42
- Related Works
- 10
- OpenAlex ID
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- OpenAlex ID
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https://openalex.org/W4200320875Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1371/journal.pone.0261226Digital Object Identifier
- Title
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Synthesis and evaluation of radiogallium-labeled long-chain fatty acid derivatives as myocardial metabolic imaging agentsWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-12-15Full publication date if available
- Authors
-
Nurmaya Effendi, Kenji Mishiro, Hiroshi Wakabayashi, Malwina Gabryel-Skrodzka, Kazuhiro Shiba, Junichi Taki, Renata Jastrząb, Seigo Kinuya, Kazuma OgawaList of authors in order
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https://doi.org/10.1371/journal.pone.0261226Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.1371/journal.pone.0261226Direct OA link when available
- Concepts
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Chemistry, Fatty acid, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
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2025: 1, 2024: 2Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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