Synthesis of fused-ring systems and diarylmethane flavonoids via ortho-quinone methide intermediates Article Swipe

View

Vidia Afina Nuraini , Valerio Falasca , Daniel S. Wenholz , David StC. Black , Naresh Kumar ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1039/d4ra08704f

Facile syntheses of a series of novel fused-ring flavanone systems via Mannich reactions and o -QM cycloadditions and evaluation of their anticancer effects.

Related Topics

Chemistry

Hydroquinone

Organic Chemistry

Concepts

Quinone methide Ring (chemistry) Chemistry Quinone Stereochemistry Organic chemistry

Metadata

Type: article
Language: en
Landing Page: https://doi.org/10.1039/d4ra08704f
OA Status: gold
Cited By: 2
References: 47
Related Works: 10
OpenAlex ID: https://openalex.org/W4406932828

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4406932828

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1039/d4ra08704f

Digital Object Identifier
Title: Synthesis of fused-ring systems and diarylmethane flavonoids via ortho-quinone methide intermediates

Work title
Type: article

OpenAlex work type
Language: en

Primary language
Publication year: 2025

Year of publication
Publication date: 2025-01-01

Full publication date if available
Authors: Vidia Afina Nuraini, Valerio Falasca, Daniel S. Wenholz, David StC. Black, Naresh Kumar

List of authors in order
Landing page: https://doi.org/10.1039/d4ra08704f

Publisher landing page
Open access: Yes

Whether a free full text is available
OA status: gold

Open access status per OpenAlex
OA URL: https://doi.org/10.1039/d4ra08704f

Direct OA link when available
Concepts: Quinone methide, Ring (chemistry), Chemistry, Quinone, Stereochemistry, Organic chemistry

Top concepts (fields/topics) attached by OpenAlex
Cited by: 2

Total citation count in OpenAlex
Citations by year (recent): 2025: 2

Per-year citation counts (last 5 years)
References (count): 47

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4406932828
doi	https://doi.org/10.1039/d4ra08704f
ids.doi	https://doi.org/10.1039/d4ra08704f
ids.pmid	https://pubmed.ncbi.nlm.nih.gov/39882010
ids.openalex	https://openalex.org/W4406932828
fwci	4.41423655
type	article
title	Synthesis of fused-ring systems and diarylmethane flavonoids via ortho-quinone methide intermediates
biblio.issue	4
biblio.volume	15
biblio.last_page	2929
biblio.first_page	2912
topics[0].id	https://openalex.org/T12973
topics[0].field.id	https://openalex.org/fields/16
topics[0].field.display_name	Chemistry
topics[0].score	1.0
topics[0].domain.id	https://openalex.org/domains/3
topics[0].domain.display_name	Physical Sciences
topics[0].subfield.id	https://openalex.org/subfields/1605
topics[0].subfield.display_name	Organic Chemistry
topics[0].display_name	Synthesis of Indole Derivatives
topics[1].id	https://openalex.org/T10817
topics[1].field.id	https://openalex.org/fields/16
topics[1].field.display_name	Chemistry
topics[1].score	0.9941999912261963
topics[1].domain.id	https://openalex.org/domains/3
topics[1].domain.display_name	Physical Sciences
topics[1].subfield.id	https://openalex.org/subfields/1605
topics[1].subfield.display_name	Organic Chemistry
topics[1].display_name	Multicomponent Synthesis of Heterocycles
topics[2].id	https://openalex.org/T13023
topics[2].field.id	https://openalex.org/fields/27
topics[2].field.display_name	Medicine
topics[2].score	0.9936000108718872
topics[2].domain.id	https://openalex.org/domains/4
topics[2].domain.display_name	Health Sciences
topics[2].subfield.id	https://openalex.org/subfields/2736
topics[2].subfield.display_name	Pharmacology
topics[2].display_name	Synthesis of Organic Compounds
funders[0].id	https://openalex.org/F4320320965
funders[0].ror	https://ror.org/03r8z3t63
funders[0].display_name	University of New South Wales
funders[1].id	https://openalex.org/F4320328515
funders[1].ror
funders[1].display_name	Lembaga Pengelola Dana Pendidikan
is_xpac	False
apc_list.value	850
apc_list.currency	GBP
apc_list.value_usd	1042
apc_paid.value	850
apc_paid.currency	GBP
apc_paid.value_usd	1042
concepts[0].id	https://openalex.org/C2778407918
concepts[0].level	3
concepts[0].score	0.9498039484024048
concepts[0].wikidata	https://www.wikidata.org/wiki/Q7272333
concepts[0].display_name	Quinone methide
concepts[1].id	https://openalex.org/C2780378348
concepts[1].level	2
concepts[1].score	0.7410982251167297
concepts[1].wikidata	https://www.wikidata.org/wiki/Q25351438
concepts[1].display_name	Ring (chemistry)
concepts[2].id	https://openalex.org/C185592680
concepts[2].level	0
concepts[2].score	0.683404803276062
concepts[2].wikidata	https://www.wikidata.org/wiki/Q2329
concepts[2].display_name	Chemistry
concepts[3].id	https://openalex.org/C2780643102
concepts[3].level	2
concepts[3].score	0.49150168895721436
concepts[3].wikidata	https://www.wikidata.org/wiki/Q412382
concepts[3].display_name	Quinone
concepts[4].id	https://openalex.org/C71240020
concepts[4].level	1
concepts[4].score	0.4897055923938751
concepts[4].wikidata	https://www.wikidata.org/wiki/Q186011
concepts[4].display_name	Stereochemistry
concepts[5].id	https://openalex.org/C178790620
concepts[5].level	1
concepts[5].score	0.24248859286308289
concepts[5].wikidata	https://www.wikidata.org/wiki/Q11351
concepts[5].display_name	Organic chemistry
keywords[0].id	https://openalex.org/keywords/quinone-methide
keywords[0].score	0.9498039484024048
keywords[0].display_name	Quinone methide
keywords[1].id	https://openalex.org/keywords/ring
keywords[1].score	0.7410982251167297
keywords[1].display_name	Ring (chemistry)
keywords[2].id	https://openalex.org/keywords/chemistry
keywords[2].score	0.683404803276062
keywords[2].display_name	Chemistry
keywords[3].id	https://openalex.org/keywords/quinone
keywords[3].score	0.49150168895721436
keywords[3].display_name	Quinone
keywords[4].id	https://openalex.org/keywords/stereochemistry
keywords[4].score	0.4897055923938751
keywords[4].display_name	Stereochemistry
keywords[5].id	https://openalex.org/keywords/organic-chemistry
keywords[5].score	0.24248859286308289
keywords[5].display_name	Organic chemistry
language	en
locations[0].id	doi:10.1039/d4ra08704f
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S2481244646
locations[0].source.issn	2046-2069
locations[0].source.type	journal
locations[0].source.is_oa	True
locations[0].source.issn_l	2046-2069
locations[0].source.is_core	True
locations[0].source.is_in_doaj	True
locations[0].source.display_name	RSC Advances
locations[0].source.host_organization	https://openalex.org/P4310320556
locations[0].source.host_organization_name	Royal Society of Chemistry
locations[0].source.host_organization_lineage	https://openalex.org/P4310320556
locations[0].source.host_organization_lineage_names	Royal Society of Chemistry
locations[0].license
locations[0].pdf_url
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	RSC Advances
locations[0].landing_page_url	https://doi.org/10.1039/d4ra08704f
locations[1].id	pmid:39882010
locations[1].is_oa	False
locations[1].source.id	https://openalex.org/S4306525036
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	PubMed
locations[1].source.host_organization	https://openalex.org/I1299303238
locations[1].source.host_organization_name	National Institutes of Health
locations[1].source.host_organization_lineage	https://openalex.org/I1299303238
locations[1].license
locations[1].pdf_url
locations[1].version	publishedVersion
locations[1].raw_type
locations[1].license_id
locations[1].is_accepted	True
locations[1].is_published	True
locations[1].raw_source_name	RSC advances
locations[1].landing_page_url	https://pubmed.ncbi.nlm.nih.gov/39882010
locations[2].id	pmh:oai:pubmedcentral.nih.gov:11775649
locations[2].is_oa	True
locations[2].source.id	https://openalex.org/S2764455111
locations[2].source.issn
locations[2].source.type	repository
locations[2].source.is_oa	False
locations[2].source.issn_l
locations[2].source.is_core	False
locations[2].source.is_in_doaj	False
locations[2].source.display_name	PubMed Central
locations[2].source.host_organization	https://openalex.org/I1299303238
locations[2].source.host_organization_name	National Institutes of Health
locations[2].source.host_organization_lineage	https://openalex.org/I1299303238
locations[2].license
locations[2].pdf_url
locations[2].version	submittedVersion
locations[2].raw_type	Text
locations[2].license_id
locations[2].is_accepted	False
locations[2].is_published	False
locations[2].raw_source_name	RSC Adv
locations[2].landing_page_url	https://www.ncbi.nlm.nih.gov/pmc/articles/11775649
indexed_in	crossref, doaj, pubmed
authorships[0].author.id	https://openalex.org/A5027490907
authorships[0].author.orcid
authorships[0].author.display_name	Vidia Afina Nuraini
authorships[0].countries	AU, ID
authorships[0].affiliations[0].institution_ids	https://openalex.org/I130218214
authorships[0].affiliations[0].raw_affiliation_string	Study Program of Chemistry, Universitas Pendidikan Indonesia, Jl. Dr Setiabudhi 229, Bandung 40154, Indonesia
authorships[0].affiliations[1].institution_ids	https://openalex.org/I31746571
authorships[0].affiliations[1].raw_affiliation_string	School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia
authorships[0].institutions[0].id	https://openalex.org/I31746571
authorships[0].institutions[0].ror	https://ror.org/03r8z3t63
authorships[0].institutions[0].type	education
authorships[0].institutions[0].lineage	https://openalex.org/I31746571
authorships[0].institutions[0].country_code	AU
authorships[0].institutions[0].display_name	UNSW Sydney
authorships[0].institutions[1].id	https://openalex.org/I130218214
authorships[0].institutions[1].ror	https://ror.org/044b0xj37
authorships[0].institutions[1].type	education
authorships[0].institutions[1].lineage	https://openalex.org/I130218214
authorships[0].institutions[1].country_code	ID
authorships[0].institutions[1].display_name	Indonesia University of Education
authorships[0].author_position	first
authorships[0].raw_author_name	Vidia A. Nuraini
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia, Study Program of Chemistry, Universitas Pendidikan Indonesia, Jl. Dr Setiabudhi 229, Bandung 40154, Indonesia
authorships[1].author.id	https://openalex.org/A5060510429
authorships[1].author.orcid	https://orcid.org/0000-0002-3592-9034
authorships[1].author.display_name	Valerio Falasca
authorships[1].countries	AU
authorships[1].affiliations[0].institution_ids	https://openalex.org/I31746571
authorships[1].affiliations[0].raw_affiliation_string	School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia
authorships[1].institutions[0].id	https://openalex.org/I31746571
authorships[1].institutions[0].ror	https://ror.org/03r8z3t63
authorships[1].institutions[0].type	education
authorships[1].institutions[0].lineage	https://openalex.org/I31746571
authorships[1].institutions[0].country_code	AU
authorships[1].institutions[0].display_name	UNSW Sydney
authorships[1].author_position	middle
authorships[1].raw_author_name	Valerio Falasca
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia
authorships[2].author.id	https://openalex.org/A5025802097
authorships[2].author.orcid	https://orcid.org/0000-0002-5526-4359
authorships[2].author.display_name	Daniel S. Wenholz
authorships[2].countries	AU
authorships[2].affiliations[0].raw_affiliation_string	Noxopharm Limited, Chatswood, NSW, Australia
authorships[2].affiliations[1].institution_ids	https://openalex.org/I31746571
authorships[2].affiliations[1].raw_affiliation_string	School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia
authorships[2].institutions[0].id	https://openalex.org/I31746571
authorships[2].institutions[0].ror	https://ror.org/03r8z3t63
authorships[2].institutions[0].type	education
authorships[2].institutions[0].lineage	https://openalex.org/I31746571
authorships[2].institutions[0].country_code	AU
authorships[2].institutions[0].display_name	UNSW Sydney
authorships[2].author_position	middle
authorships[2].raw_author_name	Daniel S. Wenholz
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	Noxopharm Limited, Chatswood, NSW, Australia, School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia
authorships[3].author.id	https://openalex.org/A5042129724
authorships[3].author.orcid	https://orcid.org/0000-0001-9300-4737
authorships[3].author.display_name	David StC. Black
authorships[3].countries	AU
authorships[3].affiliations[0].institution_ids	https://openalex.org/I31746571
authorships[3].affiliations[0].raw_affiliation_string	School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia
authorships[3].institutions[0].id	https://openalex.org/I31746571
authorships[3].institutions[0].ror	https://ror.org/03r8z3t63
authorships[3].institutions[0].type	education
authorships[3].institutions[0].lineage	https://openalex.org/I31746571
authorships[3].institutions[0].country_code	AU
authorships[3].institutions[0].display_name	UNSW Sydney
authorships[3].author_position	middle
authorships[3].raw_author_name	David StC. Black
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia
authorships[4].author.id	https://openalex.org/A5100634543
authorships[4].author.orcid	https://orcid.org/0000-0002-0951-9621
authorships[4].author.display_name	Naresh Kumar
authorships[4].countries	AU
authorships[4].affiliations[0].institution_ids	https://openalex.org/I31746571
authorships[4].affiliations[0].raw_affiliation_string	School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia
authorships[4].institutions[0].id	https://openalex.org/I31746571
authorships[4].institutions[0].ror	https://ror.org/03r8z3t63
authorships[4].institutions[0].type	education
authorships[4].institutions[0].lineage	https://openalex.org/I31746571
authorships[4].institutions[0].country_code	AU
authorships[4].institutions[0].display_name	UNSW Sydney
authorships[4].author_position	last
authorships[4].raw_author_name	Naresh Kumar
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia
has_content.pdf	False
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://doi.org/10.1039/d4ra08704f
open_access.oa_status	gold
open_access.any_repository_has_fulltext	False
created_date	2025-01-30T00:00:00
display_name	Synthesis of fused-ring systems and diarylmethane flavonoids via ortho-quinone methide intermediates
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T12973
primary_topic.field.id	https://openalex.org/fields/16
primary_topic.field.display_name	Chemistry
primary_topic.score	1.0
primary_topic.domain.id	https://openalex.org/domains/3
primary_topic.domain.display_name	Physical Sciences
primary_topic.subfield.id	https://openalex.org/subfields/1605
primary_topic.subfield.display_name	Organic Chemistry
primary_topic.display_name	Synthesis of Indole Derivatives
related_works	https://openalex.org/W4391375266, https://openalex.org/W1967860679, https://openalex.org/W2003302531, https://openalex.org/W2067042484, https://openalex.org/W1967712579, https://openalex.org/W2131538346, https://openalex.org/W4241809051, https://openalex.org/W2006826001, https://openalex.org/W2951810408, https://openalex.org/W2104975925
cited_by_count	2
counts_by_year[0].year	2025
counts_by_year[0].cited_by_count	2
locations_count	3
best_oa_location.id	doi:10.1039/d4ra08704f
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S2481244646
best_oa_location.source.issn	2046-2069
best_oa_location.source.type	journal
best_oa_location.source.is_oa	True
best_oa_location.source.issn_l	2046-2069
best_oa_location.source.is_core	True
best_oa_location.source.is_in_doaj	True
best_oa_location.source.display_name	RSC Advances
best_oa_location.source.host_organization	https://openalex.org/P4310320556
best_oa_location.source.host_organization_name	Royal Society of Chemistry
best_oa_location.source.host_organization_lineage	https://openalex.org/P4310320556
best_oa_location.source.host_organization_lineage_names	Royal Society of Chemistry
best_oa_location.license
best_oa_location.pdf_url
best_oa_location.version	publishedVersion
best_oa_location.raw_type	journal-article
best_oa_location.license_id
best_oa_location.is_accepted	True
best_oa_location.is_published	True
best_oa_location.raw_source_name	RSC Advances
best_oa_location.landing_page_url	https://doi.org/10.1039/d4ra08704f
primary_location.id	doi:10.1039/d4ra08704f
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S2481244646
primary_location.source.issn	2046-2069
primary_location.source.type	journal
primary_location.source.is_oa	True
primary_location.source.issn_l	2046-2069
primary_location.source.is_core	True
primary_location.source.is_in_doaj	True
primary_location.source.display_name	RSC Advances
primary_location.source.host_organization	https://openalex.org/P4310320556
primary_location.source.host_organization_name	Royal Society of Chemistry
primary_location.source.host_organization_lineage	https://openalex.org/P4310320556
primary_location.source.host_organization_lineage_names	Royal Society of Chemistry
primary_location.license
primary_location.pdf_url
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	RSC Advances
primary_location.landing_page_url	https://doi.org/10.1039/d4ra08704f
publication_date	2025-01-01
publication_year	2025
referenced_works	https://openalex.org/W2109483752, https://openalex.org/W2946049599, https://openalex.org/W4313587978, https://openalex.org/W2170479969, https://openalex.org/W2137522598, https://openalex.org/W2046183902, https://openalex.org/W2911273765, https://openalex.org/W1515251819, https://openalex.org/W2043566285, https://openalex.org/W2315010272, https://openalex.org/W2134977638, https://openalex.org/W2092999115, https://openalex.org/W2345005972, https://openalex.org/W2036821043, https://openalex.org/W2341353291, https://openalex.org/W2950830097, https://openalex.org/W2277272100, https://openalex.org/W2074214865, https://openalex.org/W2047710091, https://openalex.org/W2096095251, https://openalex.org/W2169303530, https://openalex.org/W2603103039, https://openalex.org/W2579124279, https://openalex.org/W2548174718, https://openalex.org/W2587467193, https://openalex.org/W1968539328, https://openalex.org/W1530000774, https://openalex.org/W2066069189, https://openalex.org/W2172409555, https://openalex.org/W2156682732, https://openalex.org/W1968896254, https://openalex.org/W1416485680, https://openalex.org/W2143719775, https://openalex.org/W2467831794, https://openalex.org/W1968224788, https://openalex.org/W2039547504, https://openalex.org/W2022046918, https://openalex.org/W2132301852, https://openalex.org/W2949395534, https://openalex.org/W2052167854, https://openalex.org/W1988055030, https://openalex.org/W2795534427, https://openalex.org/W2589253199, https://openalex.org/W2584265948, https://openalex.org/W1869454284, https://openalex.org/W2112229424, https://openalex.org/W2604186167
referenced_works_count	47
abstract_inverted_index.a	3
abstract_inverted_index.o	14
abstract_inverted_index.of	2, 5, 19
abstract_inverted_index.-QM	15
abstract_inverted_index.and	13, 17
abstract_inverted_index.via	10
abstract_inverted_index.novel	6
abstract_inverted_index.their	20
abstract_inverted_index.Facile	0
abstract_inverted_index.series	4
abstract_inverted_index.Mannich	11
abstract_inverted_index.systems	9
abstract_inverted_index.effects.	22
abstract_inverted_index.flavanone	8
abstract_inverted_index.reactions	12
abstract_inverted_index.syntheses	1
abstract_inverted_index.anticancer	21
abstract_inverted_index.evaluation	18
abstract_inverted_index.fused-ring	7
abstract_inverted_index.cycloadditions	16
cited_by_percentile_year.max	97
cited_by_percentile_year.min	95
countries_distinct_count	2
institutions_distinct_count	5
citation_normalized_percentile.value	0.87617465
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	True