Synthesis of Imine Congeners of Resveratrol and Evaluation of Their Anti-Platelet Activity Article Swipe

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Mohammad A. Bigdeli , Maryam Sabbaghan , Marjan Esfahanizadeh , Farzad Kobarfard , Sara Vitalini , Marcello Iriti , Javad Sharifi‐Rad ·

YOU? · · 2018 · Open Access · · DOI: https://doi.org/10.3390/m1039

Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a cardioprotective phytochemical occurring in many plant products. In this study, a new series of imine congeners of resveratrol has been synthesized in which the imine moiety replaced the double bond in the structure of resveratrol. In addition, the in vitro antiplatelet activity of these resveratrol derivatives has been evaluated against adenosine diphosphate (ADP), arachidonic acid (AA), and collagen as platelet aggregation inducers. In general, the synthesized compounds were active as antiplatelet agents, and, therefore, the imine functional group may be considered as an effective replacement for a double bond in resveratrol for developing new and promising antiplatelet drugs.

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Resveratrol Chemistry Imine Double bond Moiety Phytoalexin Phytochemical Stereochemistry Biochemistry Organic chemistry Catalysis

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Type: article
Language: en
Landing Page: https://doi.org/10.3390/m1039
PDF: https://www.mdpi.com/1422-8599/2019/1/M1039/pdf?version=1545634386
OA Status: gold
Cited By: 6
References: 41
Related Works: 10
OpenAlex ID: https://openalex.org/W2906546817

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DOI: https://doi.org/10.3390/m1039

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Title: Synthesis of Imine Congeners of Resveratrol and Evaluation of Their Anti-Platelet Activity

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Type: article

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Language: en

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Publication year: 2018

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Publication date: 2018-12-22

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Authors: Mohammad A. Bigdeli, Maryam Sabbaghan, Marjan Esfahanizadeh, Farzad Kobarfard, Sara Vitalini, Marcello Iriti, Javad Sharifi‐Rad

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Landing page: https://doi.org/10.3390/m1039

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Concepts: Resveratrol, Chemistry, Imine, Double bond, Moiety, Phytoalexin, Phytochemical, Stereochemistry, Biochemistry, Organic chemistry, Catalysis

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Cited by: 6

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