System-Level Sensitivity Analysis of SiNW-bioFET-Based Biosensing Using Lock-In Amplification Article Swipe
François Patou
,
Maria Dimaki
,
Claus Kjargaard
,
Jan Madsen
,
Winnie Edith Svendsen
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1109/jsen.2017.2742018
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1109/jsen.2017.2742018
Although Silicon Nanowire biological Field-Effect Transistors (SiNW-bioFETs) have steadily demonstrated their ability to detect biological markers at ultra-low concentration, they have not yet translated into routine diagnostics applications. One of the challenges inherent to the technology is that it requires an instrumentation capable of recovering ultra-low signal variations from sensors usually designed and operated in a highly-resistive configuration. Often overlooked, the SiNWbioFET/ instrument interactions are yet critical factors in determining overall system biodetection performances. Here, we carry out for the first time the system-level sensitivity analysis of a generic SiNW-bioFET model coupled to a custom-design instrument based on the lock-in amplifier. By investigating a large parametric space spanning over both sensor and instrumentation specifications, we demonstrate that systemwide investigations can be instrumental in identifying the design trade-offs that will ensure the lowest Limits-of-Detection. The generic character of our analytical model allows us to elaborate on the most general SiNW-bioFET/instrument interactions and their overall implications on detection performances. Our model can be adapted to better match specific sensor or instrument designs to either ensure that ultra-high sensitivity SiNW-bioFETs are coupled with an appropriately sensitive and noise-rejecting instrumentation, or to best tailor SiNW-bioFET design to the specifications of an existing instrument.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1109/jsen.2017.2742018
- OA Status
- green
- Cited By
- 5
- References
- 35
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W2748984026Canonical identifier for this work in OpenAlex
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https://doi.org/10.1109/jsen.2017.2742018Digital Object Identifier
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System-Level Sensitivity Analysis of SiNW-bioFET-Based Biosensing Using Lock-In AmplificationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2017Year of publication
- Publication date
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2017-08-21Full publication date if available
- Authors
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François Patou, Maria Dimaki, Claus Kjargaard, Jan Madsen, Winnie Edith SvendsenList of authors in order
- Landing page
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https://doi.org/10.1109/jsen.2017.2742018Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://orbit.dtu.dk/en/publications/957c8c6e-dc49-435c-a5c2-5c725e90e4e6Direct OA link when available
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Biosensor, Sensitivity (control systems), Lock (firearm), Materials science, Optoelectronics, Computer science, Nanotechnology, Electronic engineering, Engineering, Mechanical engineeringTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
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2025: 1, 2022: 1, 2021: 2, 2018: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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