Systematic identification and characterization of long non-coding RNAs in mouse mature sperm Article Swipe
Xiaoning Zhang
,
Fengxin Gao
,
Jianbo Fu
,
Peng Zhang
,
Yuqing Wang
,
Xuhui Zeng
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0173402
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0173402
Increasing studies have shown that mature spermatozoa contain many transcripts including mRNAs and miRNAs. However, the expression profile of long non-coding RNAs (lncRNAs) in mammalian sperm has not been systematically investigated. Here, we used highly purified RNA to investigate lncRNA expression profiles in mouse mature sperm by stranded-specific RNA-seq. We identified 20,907 known and 4,088 novel lncRNAs transcripts, and the existence of intact lncRNAs was confirmed by RT-PCR and fluorescence in situ hybridization on two representative lncRNAs. Compared to round spermatids, 1,794 upregulated and 165 downregulated lncRNAs and 4,435 upregulated and 3,920 downregulated mRNAs were identified in sperm. Based on the "Cis and Trans" RNA-RNA interaction principle, we found 14,259 targeted coding genes of differently expressed lncRNAs. In terms of Gene ontology (GO) analysis, differentially expressed lncRNAs targeted genes mainly related to nucleic acid metabolic, protein modification, chromatin and histone modification, heterocycle compound metabolic, sperm function, spermatogenesis and other processes. In contrast, differentially expressed transcripts of mRNAs were highly enriched for protein metabolic process and RNA metabolic, spermatogenesis, sperm motility, cell cycle, chromatin organization, heterocycle and aromatic compound metabolic processes. Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis showed that the differentially expressed lncRNAs were involved in RNA transport, mRNA surveillance pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, protein processing in endoplasmic reticulum. Metabolic pathways, mRNA surveillance pathway, AMPK signaling pathway, cell cycle, RNA transport splicesome and endocytosis incorporated with the differentially expressed mRNA. Furthermore, many lncRNAs were specifically expressed in testis/sperm, and 880 lncRNAs were conserved between human and mouse. In summary, this study provides a preliminary database valuable for identifying lncRNAs critical in the late stage of spermatogenesis or important for sperm function regulation, fertilization and early embryo development.
Related Topics
Concepts
Biology
KEGG
RNA
Chromatin
Cell biology
Long non-coding RNA
microRNA
Gene
XIST
Messenger RNA
Gene expression
Genetics
Transcriptome
X chromosome
X-inactivation
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0173402
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0173402&type=printable
- OA Status
- gold
- Cited By
- 59
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2595616599
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2595616599Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1371/journal.pone.0173402Digital Object Identifier
- Title
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Systematic identification and characterization of long non-coding RNAs in mouse mature spermWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-03-14Full publication date if available
- Authors
-
Xiaoning Zhang, Fengxin Gao, Jianbo Fu, Peng Zhang, Yuqing Wang, Xuhui ZengList of authors in order
- Landing page
-
https://doi.org/10.1371/journal.pone.0173402Publisher landing page
- PDF URL
-
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0173402&type=printableDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0173402&type=printableDirect OA link when available
- Concepts
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Biology, KEGG, RNA, Chromatin, Cell biology, Long non-coding RNA, microRNA, Gene, XIST, Messenger RNA, Gene expression, Genetics, Transcriptome, X chromosome, X-inactivationTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
59Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 3, 2023: 4, 2022: 8, 2021: 7Per-year citation counts (last 5 years)
- References (count)
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41Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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