Systematic low-grade chronic inflammation and intrinsic mechanisms in polycystic ovary syndrome Article Swipe
Hongxia Deng
,
Yan Chen
,
Jiadi Xing
,
Nannan Zhang
,
Liangzhi Xu
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2024.1470283
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2024.1470283
Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder affecting 6-20% of women of childbearing age worldwide. Immune cell imbalance and dysregulation of inflammatory factors can lead to systematic low-grade chronic inflammation (SLCI), which plays a pivotal role in the pathogenesis of PCOS. A significant higher infiltration of immune cells such as macrophages and lymphocytes and pro-inflammatory factors IL-6 and TNF-α has been detected in PCOS organ systems, impacting not only the female reproductive system but also other organs such as the cardiovascular, intestine, liver, thyroid, brain and other organs. Obesity, insulin resistance (IR), steroid hormones imbalance and intestinal microecological imbalance, deficiencies in vitamin D and selenium, as well as hyperhomocysteinemia (HHcy) can induce systematic imbalance between pro-inflammatory and anti-inflammatory cells and molecules. The pro-inflammatory cells and cytokines also interact with obesity, steroid hormones imbalance and IR, leading to increased metabolic imbalance and reproductive-endocrine dysfunction in PCOS patients. This review aims to summarize the dysregulation of immune response in PCOS organ system and the intrinsic mechanisms affecting SLCI in PCOS to provide new insights for the systemic inflammatory treatment of PCOS in the future.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2024.1470283
- https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1470283/pdf
- OA Status
- gold
- Cited By
- 28
- References
- 260
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4405609274
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4405609274Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fimmu.2024.1470283Digital Object Identifier
- Title
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Systematic low-grade chronic inflammation and intrinsic mechanisms in polycystic ovary syndromeWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-12-19Full publication date if available
- Authors
-
Hongxia Deng, Yan Chen, Jiadi Xing, Nannan Zhang, Liangzhi XuList of authors in order
- Landing page
-
https://doi.org/10.3389/fimmu.2024.1470283Publisher landing page
- PDF URL
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https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1470283/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1470283/pdfDirect OA link when available
- Concepts
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Polycystic ovary, Inflammation, Immune system, Insulin resistance, Endocrine system, Medicine, Hormone, Endocrinology, Internal medicine, Metabolic syndrome, Immunology, Diabetes mellitusTop concepts (fields/topics) attached by OpenAlex
- Cited by
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28Total citation count in OpenAlex
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2025: 28Per-year citation counts (last 5 years)
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260Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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