Systemic Complement Activation Profiles in Nonexudative Age-Related Macular Degeneration: A Meta-Analysis Article Swipe
Jonathan B. Lin
,
Stylianos Serghiou
,
Joan W. Miller
,
Demetrios G. Vavvas
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/jcm11092371
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/jcm11092371
Although complement inhibition has emerged as a possible therapeutic strategy for age-related macular degeneration (AMD), there is not a clear consensus regarding what aspects of the complement pathway are dysregulated in AMD and when this occurs relative to disease stage. We recently published a systematic review describing systemic complement activation profiles in patients with early/intermediate AMD or geographic atrophy (GA) compared to non-AMD controls. Here, we sought to meta-analyze these results to estimate the magnitude of complement dysregulation in AMD using restricted maximum likelihood estimation. The seven meta-analyzed studies included 710 independent participants with 23 effect sizes. Compared with non-AMD controls, patients with early/intermediate nonexudative AMD (N = 246) had significantly higher systemic complement activation, as quantified by the levels of complement proteins generated by common final pathway activation, and significantly lower systemic complement inhibition. In contrast, there were no statistically significant differences in the systemic levels of complement common final pathway activation products or complement inhibition in patients with GA (N = 178) versus non-AMD controls. We provide evidence that systemic complement over-activation is a feature of early/intermediate nonexudative AMD; no such evidence was identified for patients with GA. These findings provide mechanistic insights and inform future clinical trials.
Related Topics
Concepts
Macular degeneration
Complement system
Medicine
Meta-analysis
Complement (music)
Alternative complement pathway
Geographic atrophy
Immunology
Complement component 3
Internal medicine
Antibody
Phenotype
Genetics
Ophthalmology
Biology
Gene
Complementation
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm11092371
- https://www.mdpi.com/2077-0383/11/9/2371/pdf?version=1650709102
- OA Status
- gold
- Cited By
- 5
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4224276471
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4224276471Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/jcm11092371Digital Object Identifier
- Title
-
Systemic Complement Activation Profiles in Nonexudative Age-Related Macular Degeneration: A Meta-AnalysisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-04-23Full publication date if available
- Authors
-
Jonathan B. Lin, Stylianos Serghiou, Joan W. Miller, Demetrios G. VavvasList of authors in order
- Landing page
-
https://doi.org/10.3390/jcm11092371Publisher landing page
- PDF URL
-
https://www.mdpi.com/2077-0383/11/9/2371/pdf?version=1650709102Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2077-0383/11/9/2371/pdf?version=1650709102Direct OA link when available
- Concepts
-
Macular degeneration, Complement system, Medicine, Meta-analysis, Complement (music), Alternative complement pathway, Geographic atrophy, Immunology, Complement component 3, Internal medicine, Antibody, Phenotype, Genetics, Ophthalmology, Biology, Gene, ComplementationTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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26Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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