Systemic Dosing of Thymosin Beta 4 before and after Ischemia Does Not Attenuate Global Myocardial Ischemia-Reperfusion Injury in Pigs Article Swipe
Christoffer Stark
,
Miikka Tarkia
,
Rasmus Kentala
,
Markus Malmberg
,
Tommi Vähäsilta
,
Matti Savo
,
Ville-Veikko Hynninen
,
Mikko Helenius
,
Saku Ruohonen
,
Juho Jalkanen
,
Pekka Taimen
,
Tero‐Pekka Alastalo
,
Antti Saraste
,
Juhani Knuuti
,
Timo Savunen
,
Juha Koskenvuo
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2016.00115
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2016.00115
The use of cardiopulmonary bypass (CPB) and aortic cross-clamping causes myocardial ischemia-reperfusion injury (I-RI) and can lead to reduced postoperative cardiac function. We investigated whether this injury could be attenuated by thymosin beta 4 (TB4), a peptide which has showed cardioprotective effects. Pigs received either TB4 or vehicle and underwent CPB and aortic cross-clamping for 60 min with cold intermittent blood-cardioplegia and were then followed for 30 h. Myocardial function and blood flow was studied by cardiac magnetic resonance and PET imaging. Tissue and plasma samples were analyzed to determine the amount of cardiomyocyte necrosis and apoptosis as well as pharmacokinetics of the peptide. In vitro studies were performed to assess its influence on blood coagulation and vasomotor tone. Serum levels of the peptide were increased after administration compared to control samples. TB4 did not decrease the amount of cell death. Cardiac function and global myocardial blood flow was similar between the study groups. At high doses a vasoconstrictor effect on mesentery arteries and a vasodilator effect on coronary arteries was observed and blood clot firmness was reduced when tested in the presence of an antiplatelet agent. Despite promising results in previous trials the cardioprotective effect of TB4 was not demonstrated in this model for global myocardial I-RI.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fphar.2016.00115
- https://www.frontiersin.org/articles/10.3389/fphar.2016.00115/pdf
- OA Status
- gold
- Cited By
- 10
- References
- 53
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2345367464
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2345367464Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fphar.2016.00115Digital Object Identifier
- Title
-
Systemic Dosing of Thymosin Beta 4 before and after Ischemia Does Not Attenuate Global Myocardial Ischemia-Reperfusion Injury in PigsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-05-03Full publication date if available
- Authors
-
Christoffer Stark, Miikka Tarkia, Rasmus Kentala, Markus Malmberg, Tommi Vähäsilta, Matti Savo, Ville-Veikko Hynninen, Mikko Helenius, Saku Ruohonen, Juho Jalkanen, Pekka Taimen, Tero‐Pekka Alastalo, Antti Saraste, Juhani Knuuti, Timo Savunen, Juha KoskenvuoList of authors in order
- Landing page
-
https://doi.org/10.3389/fphar.2016.00115Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fphar.2016.00115/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/articles/10.3389/fphar.2016.00115/pdfDirect OA link when available
- Concepts
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Medicine, Reperfusion injury, Ischemia, Blood flow, Cardiology, Internal medicine, Cardiopulmonary bypass, Cardiac function curve, Myocardial stunning, Vasodilation, Anesthesia, Pharmacology, Heart failureTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
10Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 1, 2022: 1, 2021: 1, 2019: 2Per-year citation counts (last 5 years)
- References (count)
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53Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| publication_year | 2016 |
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