Systemic inflammatory markers in individuals with cerebral palsy Article Swipe
Jessica Pingel
,
Lee Barber
,
Ida Torp Andersen
,
Ferdinand von Walden
,
Christian Wong
,
Simon Døssing
,
Jens Bo Nielsen
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1177/2058739218823474
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1177/2058739218823474
Individuals with cerebral palsy (CP) develop skeletal muscle contractures that impair muscle function. In turn, contractures affect the ability to ambulate and often promote a sedentary lifestyle. The aim of the present study was to investigate the systemic inflammatory markers transforming growth factor beta-1 (TGFβ1), C-reactive protein (CRP), and interleukin-6 (IL-6) in children and adults with CP. Blood samples of n = 34 participants (24 individuals with CP (n = 14 children with CP age 10.36 ± 1.1 and n = 10 adults with CP age 38.80 ± 3.6) and 10 healthy adults age 36.63 ± 3.8) were analyzed for circulating levels of TGFβ1, CRP, and IL-6 using Sandwich Enzyme linked immunosorbent assay (ELISA) analyses (R&D systems). TGFβ1 and CRP levels were significantly higher in children with CP compared to both adults with CP (TGFβ1: P < 0.0005 and P < 0.0002, respectively) and healthy adults (CRP: P < 0.0001 and P < 0.0001, respectively), while no differences were observed between the adults with CP and healthy adults in TGFβ1 ( P = 0.29) and CRP ( P = 0.59), respectively. Furthermore, IL-6 levels showed no significant differences between the groups. The present findings indicate that the level of systemic inflammation is increased in children with CP. We speculate that persisting inflammation in children with CP might influence the development of muscle contractures, resulting in reduced muscle mass and marked muscle weakness in adults with CP.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/2058739218823474
- https://journals.sagepub.com/doi/pdf/10.1177/2058739218823474
- OA Status
- gold
- Cited By
- 22
- References
- 12
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2912199795
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2912199795Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1177/2058739218823474Digital Object Identifier
- Title
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Systemic inflammatory markers in individuals with cerebral palsyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
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2019-01-01Full publication date if available
- Authors
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Jessica Pingel, Lee Barber, Ida Torp Andersen, Ferdinand von Walden, Christian Wong, Simon Døssing, Jens Bo NielsenList of authors in order
- Landing page
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https://doi.org/10.1177/2058739218823474Publisher landing page
- PDF URL
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https://journals.sagepub.com/doi/pdf/10.1177/2058739218823474Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://journals.sagepub.com/doi/pdf/10.1177/2058739218823474Direct OA link when available
- Concepts
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Medicine, Cerebral palsy, Internal medicine, Inflammation, Muscle contracture, Muscle weakness, Young adult, C-reactive protein, Endocrinology, Gastroenterology, Physical therapy, SurgeryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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22Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 3, 2023: 7, 2022: 3, 2021: 2Per-year citation counts (last 5 years)
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12Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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