Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis Article Swipe
É. Sbidian
,
Anna Chaimani
,
Robin Guelimi
,
I. García‐Doval
,
Camille Hua
,
Carolyn Hughes
,
Luigi Naldi
,
Maria Kinberger
,
Sivem Afach
,
Laurence Le Cleach
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/14651858.cd011535.pub6
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/14651858.cd011535.pub6
Our review shows that, compared to placebo, the biologics infliximab, bimekizumab, ixekizumab, and risankizumab were the most effective treatments for achieving PASI 90 in people with moderate-to-severe psoriasis on the basis of high-certainty evidence. This NMA evidence is limited to induction therapy (outcomes measured from 8 to 24 weeks after randomisation), and is not sufficient for evaluating longer-term outcomes in this chronic disease. Moreover, we found low numbers of studies for some of the interventions, and the young age (mean 44.6 years) and high level of disease severity (PASI 20.4 at baseline) may not be typical of patients seen in daily clinical practice. We found no significant difference in the assessed interventions and placebo in terms of SAEs, and the safety evidence for most interventions was very low to moderate quality. More randomised trials directly comparing active agents are needed, and these should include systematic subgroup analyses (sex, age, ethnicity, comorbidities, psoriatic arthritis). To provide long-term information on the safety of treatments included in this review, an evaluation of non-randomised studies is needed. Editorial note: This is a living systematic review. Living systematic reviews offer a new approach to review updating, in which the review is continually updated, incorporating relevant new evidence as it becomes available. Please refer to the Cochrane Database of Systematic Reviews for the current status of this review.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1002/14651858.cd011535.pub6
- OA Status
- green
- Cited By
- 116
- References
- 840
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4383998038
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4383998038Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/14651858.cd011535.pub6Digital Object Identifier
- Title
-
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysisWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-07-12Full publication date if available
- Authors
-
É. Sbidian, Anna Chaimani, Robin Guelimi, I. García‐Doval, Camille Hua, Carolyn Hughes, Luigi Naldi, Maria Kinberger, Sivem Afach, Laurence Le CleachList of authors in order
- Landing page
-
https://doi.org/10.1002/14651858.cd011535.pub6Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/10337265Direct OA link when available
- Concepts
-
Medicine, Meta-analysis, Adverse effect, Psoriasis, Placebo, Psoriasis Area and Severity Index, Randomized controlled trial, Data extraction, MEDLINE, Relative risk, Internal medicine, Intensive care medicine, Confidence interval, Dermatology, Alternative medicine, Pathology, Law, Political scienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
116Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 35, 2024: 45, 2023: 19, 2022: 6, 2021: 2Per-year citation counts (last 5 years)
- References (count)
-
840Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.psoriatic | 151 |
| abstract_inverted_index.updating, | 190 |
| abstract_inverted_index.Systematic | 213 |
| abstract_inverted_index.available. | 205 |
| abstract_inverted_index.difference | 107 |
| abstract_inverted_index.ethnicity, | 149 |
| abstract_inverted_index.evaluating | 56 |
| abstract_inverted_index.evaluation | 167 |
| abstract_inverted_index.randomised | 132 |
| abstract_inverted_index.sufficient | 54 |
| abstract_inverted_index.systematic | 144, 179, 182 |
| abstract_inverted_index.treatments | 18, 161 |
| abstract_inverted_index.arthritis). | 152 |
| abstract_inverted_index.continually | 196 |
| abstract_inverted_index.infliximab, | 9 |
| abstract_inverted_index.information | 156 |
| abstract_inverted_index.ixekizumab, | 11 |
| abstract_inverted_index.longer-term | 57 |
| abstract_inverted_index.significant | 106 |
| abstract_inverted_index.bimekizumab, | 10 |
| abstract_inverted_index.risankizumab | 13 |
| abstract_inverted_index.incorporating | 198 |
| abstract_inverted_index.interventions | 111, 124 |
| abstract_inverted_index.comorbidities, | 150 |
| abstract_inverted_index.high-certainty | 32 |
| abstract_inverted_index.interventions, | 74 |
| abstract_inverted_index.non-randomised | 169 |
| abstract_inverted_index.randomisation), | 50 |
| abstract_inverted_index.moderate-to-severe | 26 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 90 |
| countries_distinct_count | 5 |
| institutions_distinct_count | 10 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6399999856948853 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.99572461 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |