T-CELL RECEPTOR (TCR)-VΒ REPERTOIRE FLOW CYTOMETRY FOR T-CELL LYMPHOPROLIFERATIVE DISORDER: A RETROSPECTIVE ANALYSIS OF A SINGLE-CENTER REAL-LIFE LABORATORY EXPERIENCE Article Swipe
Marco Antonacci
,
Jacopo Micozzi
,
Alessandro Nanni Costa
,
Alessandro Laganà
,
Maria Laura Milani
,
Stefania Intoppa
,
Vittorio Bellomarino
,
Maria Grazia Nardacci
,
Mario Biglietto
,
Stefano Imperatore
,
Maria Laura Bisegna
,
Maurizio Martelli
,
Irene Della Starza
,
Maria Stefania De Propris
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.4084/mjhid.2025.016
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.4084/mjhid.2025.016
Background: Discrimination between clonal and reactive cell proliferation is critical for the correct management of T-cell lymphocytosis. Multiparametric flow cytometry (MFC) represents a valuable tool, particularly because it allows to evaluate the T-cell receptor (TCR) Vβ repertoire to pinpoint eventual clonality in T-cell lymphocytosis. A restricted expansion of a single out of the 24 evaluable families or a “clonogram-off” pattern are highly suggestive of the presence of a clonal T-cell population. However, data available on the concordance between MFC TCR-Vβ repertoire and molecular analysis of TCR gene rearrangements, which is regarded as the gold standard for assessing T-cell clonality, are limited. Objective and methods: We performed a retrospective monocentric study including 307 patients referred to our center for lymphocytosis between 2003 and 2024. The aim of our study was to investigate the diagnostic accuracy of MFC TCR-Vβ repertoire analysis and to compare its performance with molecular analysis of TCR gene rearrangements, for the identification of T-cell clonality. Results: MFC TCR-Vβ repertoire analysis demonstrated a restricted expansion of a single Vβ family in 67.5% of cases, while clonality in the remaining 32.5% was inferred by a “clonogram-off” pattern. For 215 (70%) patients both MFC TCR-Vβ repertoire analysis and molecular analysis of TCR gene rearrangements were available, showing an absolute concordance (215 out of 215 cases, 100%) between the two methods. Conclusion: MFC TCR-Vβ repertoire analysis is a rapid, cheap, sensitive, and reliable tool to identify clonal T-cell lymphocytosis. It represents an absolute valid first-line diagnostic approach, and it should be included into the routinely laboratory work-up performed MFC analysis for peripheral lymphocytosis.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4084/mjhid.2025.016
- https://www.mjhid.org/mjhid/article/download/5882/4632
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408038484
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4408038484Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.4084/mjhid.2025.016Digital Object Identifier
- Title
-
T-CELL RECEPTOR (TCR)-VΒ REPERTOIRE FLOW CYTOMETRY FOR T-CELL LYMPHOPROLIFERATIVE DISORDER: A RETROSPECTIVE ANALYSIS OF A SINGLE-CENTER REAL-LIFE LABORATORY EXPERIENCEWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-02-27Full publication date if available
- Authors
-
Marco Antonacci, Jacopo Micozzi, Alessandro Nanni Costa, Alessandro Laganà, Maria Laura Milani, Stefania Intoppa, Vittorio Bellomarino, Maria Grazia Nardacci, Mario Biglietto, Stefano Imperatore, Maria Laura Bisegna, Maurizio Martelli, Irene Della Starza, Maria Stefania De ProprisList of authors in order
- Landing page
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https://doi.org/10.4084/mjhid.2025.016Publisher landing page
- PDF URL
-
https://www.mjhid.org/mjhid/article/download/5882/4632Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mjhid.org/mjhid/article/download/5882/4632Direct OA link when available
- Concepts
-
Medicine, Flow cytometry, T-cell receptor, Single Center, Lymphoproliferative disorders, Center (category theory), T cell, Immunology, Internal medicine, Lymphoma, Crystallography, Chemistry, Immune systemTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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