Clinical and Experimental Neuroimmunology • Vol 16 • No 3
T cells from newly diagnosed multiple sclerosis patients have enhanced responsiveness to <scp>CD46</scp> activation
November 2024 • Linda Sundvall, Litten Sørensen Rossen, Vivien R. Schack, Bettina Bundgaard, Peter Vestergaard Rasmussen, Thor Petersen, Per Höllsberg
Abstract Objective To evaluate the responsiveness of T cells from newly diagnosed multiple sclerosis (MS) patients to CD46 co‐stimulation, a membrane co‐factor protein potentially involved in MS pathogenesis. Methods T cells from MS patients and non‐diseased symptomatic controls (SC) were activated in vitro with or without αCD46 antibody co‐stimulation. Cytokine responses were measured to assess T‐cell responsiveness. The fold difference between αCD3/CD46 and αCD3/isotype responses was calculated to determine the …