T Lymphocyte-Macrophage Hybrid Membrane-Coated Biomimetic Nanoparticles Alleviate Myocarditis via Suppressing Pyroptosis by Targeting Gene Silencing Article Swipe
Yulong Xiong
,
Zhenhao Zhang
,
Shangyu Liu
,
Lishui Shen
,
Lihui Zheng
,
Ligang Ding
,
Limin Liu
,
Lingmin Wu
,
Zhicheng Hu
,
Le Li
,
Zhao Hu
,
Zhuxin Zhang
,
Likun Zhou
,
Mengtong Xu
,
Yan Yao
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-4206914/v1
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-4206914/v1
Utilizing small interfering RNA (siRNA) for gene silencing presents a viable strategy for treating human diseases, including cardiovascular disorders. However, the strategic targeting and delivery of siRNA therapeutics to desired tissues or cell subtypes, followed by endosomal escape into the cytosol, remain challenging. Based on previous research, we identified interferon regulatory factor 1 (IRF1)-mediated macrophage pyroptosis as a potential therapeutic target for myocarditis. Herein, a T lymphocyte-macrophage hybrid membrane-coated zeolitic imidazolate framework-8 (ZIF-8) nano-delivery platform was fabricated for the precise conveyance of siRNA against IRF1 (siIRF1) to the pro-inflammatory M1 macrophages in myocarditis (siIRF1@ZIF@HM). The siIRF1-loaded ZIF-8 nanoparticle exhibited a high siRNA loading capacity and efficient endo-lysosomal escape ability. The application of hybrid membrane coating significantly improved M1 macrophage targeting both in vivo and in vitro . Delivery of siIRF1 effectively suppressed IRF1 expression and concomitantly inhibited pyroptosis in IFN-γ-stimulated macrophages. Consequently, the siIRF1 nanotherapeutic approach demonstrated the potential to attenuate myocardial inflammation and mitigate the progression of myocarditis. Our study reveals that the customized biomimetic nano-delivery system holds great prospects in the treatment of inflammatory diseases.
Related Topics
Concepts
Pyroptosis
Gene silencing
Macrophage
Myocarditis
RNA interference
Membrane
Cell biology
Gene
Chemistry
Biology
Immunology
Medicine
Inflammation
Inflammasome
Biochemistry
RNA
In vitro
Cardiology
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-4206914/v1
- https://www.researchsquare.com/article/rs-4206914/latest.pdf
- OA Status
- green
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4394606516
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4394606516Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-4206914/v1Digital Object Identifier
- Title
-
T Lymphocyte-Macrophage Hybrid Membrane-Coated Biomimetic Nanoparticles Alleviate Myocarditis via Suppressing Pyroptosis by Targeting Gene SilencingWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-04-09Full publication date if available
- Authors
-
Yulong Xiong, Zhenhao Zhang, Shangyu Liu, Lishui Shen, Lihui Zheng, Ligang Ding, Limin Liu, Lingmin Wu, Zhicheng Hu, Le Li, Zhao Hu, Zhuxin Zhang, Likun Zhou, Mengtong Xu, Yan YaoList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-4206914/v1Publisher landing page
- PDF URL
-
https://www.researchsquare.com/article/rs-4206914/latest.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-4206914/latest.pdfDirect OA link when available
- Concepts
-
Pyroptosis, Gene silencing, Macrophage, Myocarditis, RNA interference, Membrane, Cell biology, Gene, Chemistry, Biology, Immunology, Medicine, Inflammation, Inflammasome, Biochemistry, RNA, In vitro, CardiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
46Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4394606516 |
|---|---|
| doi | https://doi.org/10.21203/rs.3.rs-4206914/v1 |
| ids.doi | https://doi.org/10.21203/rs.3.rs-4206914/v1 |
| ids.openalex | https://openalex.org/W4394606516 |
| fwci | |
| type | preprint |
| title | T Lymphocyte-Macrophage Hybrid Membrane-Coated Biomimetic Nanoparticles Alleviate Myocarditis via Suppressing Pyroptosis by Targeting Gene Silencing |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T11112 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2705 |
| topics[0].subfield.display_name | Cardiology and Cardiovascular Medicine |
| topics[0].display_name | Viral Infections and Immunology Research |
| topics[1].id | https://openalex.org/T11495 |
| topics[1].field.id | https://openalex.org/fields/11 |
| topics[1].field.display_name | Agricultural and Biological Sciences |
| topics[1].score | 0.998199999332428 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1103 |
| topics[1].subfield.display_name | Animal Science and Zoology |
| topics[1].display_name | Animal Virus Infections Studies |
| topics[2].id | https://openalex.org/T11668 |
| topics[2].field.id | https://openalex.org/fields/24 |
| topics[2].field.display_name | Immunology and Microbiology |
| topics[2].score | 0.9976999759674072 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2403 |
| topics[2].subfield.display_name | Immunology |
| topics[2].display_name | interferon and immune responses |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C17172800 |
| concepts[0].level | 4 |
| concepts[0].score | 0.8892441987991333 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q7263707 |
| concepts[0].display_name | Pyroptosis |
| concepts[1].id | https://openalex.org/C119056186 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7714502811431885 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q1431332 |
| concepts[1].display_name | Gene silencing |
| concepts[2].id | https://openalex.org/C2779244956 |
| concepts[2].level | 3 |
| concepts[2].score | 0.5968203544616699 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q184204 |
| concepts[2].display_name | Macrophage |
| concepts[3].id | https://openalex.org/C2780875844 |
| concepts[3].level | 2 |
| concepts[3].score | 0.49676162004470825 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q186235 |
| concepts[3].display_name | Myocarditis |
| concepts[4].id | https://openalex.org/C166703698 |
| concepts[4].level | 4 |
| concepts[4].score | 0.43545907735824585 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q201993 |
| concepts[4].display_name | RNA interference |
| concepts[5].id | https://openalex.org/C41625074 |
| concepts[5].level | 2 |
| concepts[5].score | 0.413075715303421 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q176088 |
| concepts[5].display_name | Membrane |
| concepts[6].id | https://openalex.org/C95444343 |
| concepts[6].level | 1 |
| concepts[6].score | 0.40058013796806335 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[6].display_name | Cell biology |
| concepts[7].id | https://openalex.org/C104317684 |
| concepts[7].level | 2 |
| concepts[7].score | 0.3877374529838562 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[7].display_name | Gene |
| concepts[8].id | https://openalex.org/C185592680 |
| concepts[8].level | 0 |
| concepts[8].score | 0.34992900490760803 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[8].display_name | Chemistry |
| concepts[9].id | https://openalex.org/C86803240 |
| concepts[9].level | 0 |
| concepts[9].score | 0.30575281381607056 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[9].display_name | Biology |
| concepts[10].id | https://openalex.org/C203014093 |
| concepts[10].level | 1 |
| concepts[10].score | 0.24279668927192688 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[10].display_name | Immunology |
| concepts[11].id | https://openalex.org/C71924100 |
| concepts[11].level | 0 |
| concepts[11].score | 0.1713632047176361 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[11].display_name | Medicine |
| concepts[12].id | https://openalex.org/C2776914184 |
| concepts[12].level | 2 |
| concepts[12].score | 0.10423097014427185 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q101991 |
| concepts[12].display_name | Inflammation |
| concepts[13].id | https://openalex.org/C2777209026 |
| concepts[13].level | 3 |
| concepts[13].score | 0.10400736331939697 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q412405 |
| concepts[13].display_name | Inflammasome |
| concepts[14].id | https://openalex.org/C55493867 |
| concepts[14].level | 1 |
| concepts[14].score | 0.1010286808013916 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[14].display_name | Biochemistry |
| concepts[15].id | https://openalex.org/C67705224 |
| concepts[15].level | 3 |
| concepts[15].score | 0.09512683749198914 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q11053 |
| concepts[15].display_name | RNA |
| concepts[16].id | https://openalex.org/C202751555 |
| concepts[16].level | 2 |
| concepts[16].score | 0.05724099278450012 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q221681 |
| concepts[16].display_name | In vitro |
| concepts[17].id | https://openalex.org/C164705383 |
| concepts[17].level | 1 |
| concepts[17].score | 0.0 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q10379 |
| concepts[17].display_name | Cardiology |
| keywords[0].id | https://openalex.org/keywords/pyroptosis |
| keywords[0].score | 0.8892441987991333 |
| keywords[0].display_name | Pyroptosis |
| keywords[1].id | https://openalex.org/keywords/gene-silencing |
| keywords[1].score | 0.7714502811431885 |
| keywords[1].display_name | Gene silencing |
| keywords[2].id | https://openalex.org/keywords/macrophage |
| keywords[2].score | 0.5968203544616699 |
| keywords[2].display_name | Macrophage |
| keywords[3].id | https://openalex.org/keywords/myocarditis |
| keywords[3].score | 0.49676162004470825 |
| keywords[3].display_name | Myocarditis |
| keywords[4].id | https://openalex.org/keywords/rna-interference |
| keywords[4].score | 0.43545907735824585 |
| keywords[4].display_name | RNA interference |
| keywords[5].id | https://openalex.org/keywords/membrane |
| keywords[5].score | 0.413075715303421 |
| keywords[5].display_name | Membrane |
| keywords[6].id | https://openalex.org/keywords/cell-biology |
| keywords[6].score | 0.40058013796806335 |
| keywords[6].display_name | Cell biology |
| keywords[7].id | https://openalex.org/keywords/gene |
| keywords[7].score | 0.3877374529838562 |
| keywords[7].display_name | Gene |
| keywords[8].id | https://openalex.org/keywords/chemistry |
| keywords[8].score | 0.34992900490760803 |
| keywords[8].display_name | Chemistry |
| keywords[9].id | https://openalex.org/keywords/biology |
| keywords[9].score | 0.30575281381607056 |
| keywords[9].display_name | Biology |
| keywords[10].id | https://openalex.org/keywords/immunology |
| keywords[10].score | 0.24279668927192688 |
| keywords[10].display_name | Immunology |
| keywords[11].id | https://openalex.org/keywords/medicine |
| keywords[11].score | 0.1713632047176361 |
| keywords[11].display_name | Medicine |
| keywords[12].id | https://openalex.org/keywords/inflammation |
| keywords[12].score | 0.10423097014427185 |
| keywords[12].display_name | Inflammation |
| keywords[13].id | https://openalex.org/keywords/inflammasome |
| keywords[13].score | 0.10400736331939697 |
| keywords[13].display_name | Inflammasome |
| keywords[14].id | https://openalex.org/keywords/biochemistry |
| keywords[14].score | 0.1010286808013916 |
| keywords[14].display_name | Biochemistry |
| keywords[15].id | https://openalex.org/keywords/rna |
| keywords[15].score | 0.09512683749198914 |
| keywords[15].display_name | RNA |
| keywords[16].id | https://openalex.org/keywords/in-vitro |
| keywords[16].score | 0.05724099278450012 |
| keywords[16].display_name | In vitro |
| language | en |
| locations[0].id | doi:10.21203/rs.3.rs-4206914/v1 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402450 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Research Square (Research Square) |
| locations[0].source.host_organization | https://openalex.org/I4210096694 |
| locations[0].source.host_organization_name | Research Square (United States) |
| locations[0].source.host_organization_lineage | https://openalex.org/I4210096694 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.researchsquare.com/article/rs-4206914/latest.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.21203/rs.3.rs-4206914/v1 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5000673995 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-5476-6405 |
| authorships[0].author.display_name | Yulong Xiong |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I200296433, https://openalex.org/I2801228662 |
| authorships[0].affiliations[0].raw_affiliation_string | Chinese Academy of Medical Sciences and Peking Union Medical College |
| authorships[0].institutions[0].id | https://openalex.org/I200296433 |
| authorships[0].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[0].institutions[1].id | https://openalex.org/I2801228662 |
| authorships[0].institutions[1].ror | https://ror.org/04jztag35 |
| authorships[0].institutions[1].type | healthcare |
| authorships[0].institutions[1].lineage | https://openalex.org/I2801228662 |
| authorships[0].institutions[1].country_code | CN |
| authorships[0].institutions[1].display_name | Peking Union Medical College Hospital |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Yulong Xiong |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Chinese Academy of Medical Sciences and Peking Union Medical College |
| authorships[1].author.id | https://openalex.org/A5043073466 |
| authorships[1].author.orcid | https://orcid.org/0009-0006-1501-2209 |
| authorships[1].author.display_name | Zhenhao Zhang |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I200296433, https://openalex.org/I2801228662 |
| authorships[1].affiliations[0].raw_affiliation_string | Chinese Academy of Medical Sciences and Peking Union Medical College |
| authorships[1].institutions[0].id | https://openalex.org/I200296433 |
| authorships[1].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[1].institutions[1].id | https://openalex.org/I2801228662 |
| authorships[1].institutions[1].ror | https://ror.org/04jztag35 |
| authorships[1].institutions[1].type | healthcare |
| authorships[1].institutions[1].lineage | https://openalex.org/I2801228662 |
| authorships[1].institutions[1].country_code | CN |
| authorships[1].institutions[1].display_name | Peking Union Medical College Hospital |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Zhenhao Zhang |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Chinese Academy of Medical Sciences and Peking Union Medical College |
| authorships[2].author.id | https://openalex.org/A5069953819 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-8395-2741 |
| authorships[2].author.display_name | Shangyu Liu |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I200296433, https://openalex.org/I2801228662 |
| authorships[2].affiliations[0].raw_affiliation_string | Chinese Academy of Medical Sciences and Peking Union Medical College |
| authorships[2].institutions[0].id | https://openalex.org/I200296433 |
| authorships[2].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[2].institutions[1].id | https://openalex.org/I2801228662 |
| authorships[2].institutions[1].ror | https://ror.org/04jztag35 |
| authorships[2].institutions[1].type | healthcare |
| authorships[2].institutions[1].lineage | https://openalex.org/I2801228662 |
| authorships[2].institutions[1].country_code | CN |
| authorships[2].institutions[1].display_name | Peking Union Medical College Hospital |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Shangyu Liu |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Chinese Academy of Medical Sciences and Peking Union Medical College |
| authorships[3].author.id | https://openalex.org/A5075396360 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-6268-4215 |
| authorships[3].author.display_name | Lishui Shen |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I200296433, https://openalex.org/I2801228662 |
| authorships[3].affiliations[0].raw_affiliation_string | Chinese Academy of Medical Sciences and Peking Union Medical College |
| authorships[3].institutions[0].id | https://openalex.org/I200296433 |
| authorships[3].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[3].institutions[1].id | https://openalex.org/I2801228662 |
| authorships[3].institutions[1].ror | https://ror.org/04jztag35 |
| authorships[3].institutions[1].type | healthcare |
| authorships[3].institutions[1].lineage | https://openalex.org/I2801228662 |
| authorships[3].institutions[1].country_code | CN |
| authorships[3].institutions[1].display_name | Peking Union Medical College Hospital |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Lishui Shen |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Chinese Academy of Medical Sciences and Peking Union Medical College |
| authorships[4].author.id | https://openalex.org/A5101593355 |
| authorships[4].author.orcid | https://orcid.org/0009-0000-2867-411X |
| authorships[4].author.display_name | Lihui Zheng |
| authorships[4].affiliations[0].raw_affiliation_string | Fuwai Hospital |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Lihui Zheng |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Fuwai Hospital |
| authorships[5].author.id | https://openalex.org/A5066141242 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-5610-5974 |
| authorships[5].author.display_name | Ligang Ding |
| authorships[5].affiliations[0].raw_affiliation_string | Fuwai Hospital |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Ligang Ding |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Fuwai Hospital |
| authorships[6].author.id | https://openalex.org/A5110376652 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-0670-5338 |
| authorships[6].author.display_name | Limin Liu |
| authorships[6].affiliations[0].raw_affiliation_string | Fuwai Hospital |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Limin Liu |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Fuwai Hospital |
| authorships[7].author.id | https://openalex.org/A5102668264 |
| authorships[7].author.orcid | https://orcid.org/0009-0006-5180-4772 |
| authorships[7].author.display_name | Lingmin Wu |
| authorships[7].affiliations[0].raw_affiliation_string | Fuwai Hospital |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Lingmin Wu |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Fuwai Hospital |
| authorships[8].author.id | https://openalex.org/A5077776876 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-3899-0711 |
| authorships[8].author.display_name | Zhicheng Hu |
| authorships[8].affiliations[0].raw_affiliation_string | Fuwai Hospital |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Zhicheng Hu |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Fuwai Hospital |
| authorships[9].author.id | https://openalex.org/A5100450296 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-6740-9375 |
| authorships[9].author.display_name | Le Li |
| authorships[9].countries | CN |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I200296433, https://openalex.org/I2801228662 |
| authorships[9].affiliations[0].raw_affiliation_string | Chinese Academy of Medical Sciences and Peking Union Medical College |
| authorships[9].institutions[0].id | https://openalex.org/I200296433 |
| authorships[9].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[9].institutions[0].country_code | CN |
| authorships[9].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[9].institutions[1].id | https://openalex.org/I2801228662 |
| authorships[9].institutions[1].ror | https://ror.org/04jztag35 |
| authorships[9].institutions[1].type | healthcare |
| authorships[9].institutions[1].lineage | https://openalex.org/I2801228662 |
| authorships[9].institutions[1].country_code | CN |
| authorships[9].institutions[1].display_name | Peking Union Medical College Hospital |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Le Li |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Chinese Academy of Medical Sciences and Peking Union Medical College |
| authorships[10].author.id | https://openalex.org/A5101264939 |
| authorships[10].author.orcid | https://orcid.org/0009-0001-1887-6145 |
| authorships[10].author.display_name | Zhao Hu |
| authorships[10].countries | CN |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I200296433, https://openalex.org/I2801228662 |
| authorships[10].affiliations[0].raw_affiliation_string | Chinese Academy of Medical Sciences and Peking Union Medical College |
| authorships[10].institutions[0].id | https://openalex.org/I200296433 |
| authorships[10].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[10].institutions[0].country_code | CN |
| authorships[10].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[10].institutions[1].id | https://openalex.org/I2801228662 |
| authorships[10].institutions[1].ror | https://ror.org/04jztag35 |
| authorships[10].institutions[1].type | healthcare |
| authorships[10].institutions[1].lineage | https://openalex.org/I2801228662 |
| authorships[10].institutions[1].country_code | CN |
| authorships[10].institutions[1].display_name | Peking Union Medical College Hospital |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Zhao Hu |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Chinese Academy of Medical Sciences and Peking Union Medical College |
| authorships[11].author.id | https://openalex.org/A5032035060 |
| authorships[11].author.orcid | https://orcid.org/0000-0001-6048-6610 |
| authorships[11].author.display_name | Zhuxin Zhang |
| authorships[11].countries | CN |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I200296433, https://openalex.org/I2801228662 |
| authorships[11].affiliations[0].raw_affiliation_string | Chinese Academy of Medical Sciences and Peking Union Medical College |
| authorships[11].institutions[0].id | https://openalex.org/I200296433 |
| authorships[11].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[11].institutions[0].country_code | CN |
| authorships[11].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[11].institutions[1].id | https://openalex.org/I2801228662 |
| authorships[11].institutions[1].ror | https://ror.org/04jztag35 |
| authorships[11].institutions[1].type | healthcare |
| authorships[11].institutions[1].lineage | https://openalex.org/I2801228662 |
| authorships[11].institutions[1].country_code | CN |
| authorships[11].institutions[1].display_name | Peking Union Medical College Hospital |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Zhuxin Zhang |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Chinese Academy of Medical Sciences and Peking Union Medical College |
| authorships[12].author.id | https://openalex.org/A5109052434 |
| authorships[12].author.orcid | |
| authorships[12].author.display_name | Likun Zhou |
| authorships[12].countries | CN |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I200296433, https://openalex.org/I2801228662 |
| authorships[12].affiliations[0].raw_affiliation_string | Chinese Academy of Medical Sciences and Peking Union Medical College |
| authorships[12].institutions[0].id | https://openalex.org/I200296433 |
| authorships[12].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[12].institutions[0].country_code | CN |
| authorships[12].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[12].institutions[1].id | https://openalex.org/I2801228662 |
| authorships[12].institutions[1].ror | https://ror.org/04jztag35 |
| authorships[12].institutions[1].type | healthcare |
| authorships[12].institutions[1].lineage | https://openalex.org/I2801228662 |
| authorships[12].institutions[1].country_code | CN |
| authorships[12].institutions[1].display_name | Peking Union Medical College Hospital |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Likun Zhou |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Chinese Academy of Medical Sciences and Peking Union Medical College |
| authorships[13].author.id | https://openalex.org/A5013125091 |
| authorships[13].author.orcid | https://orcid.org/0009-0007-6753-9931 |
| authorships[13].author.display_name | Mengtong Xu |
| authorships[13].countries | CN |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I200296433, https://openalex.org/I2801228662 |
| authorships[13].affiliations[0].raw_affiliation_string | Chinese Academy of Medical Sciences and Peking Union Medical College |
| authorships[13].institutions[0].id | https://openalex.org/I200296433 |
| authorships[13].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[13].institutions[0].country_code | CN |
| authorships[13].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[13].institutions[1].id | https://openalex.org/I2801228662 |
| authorships[13].institutions[1].ror | https://ror.org/04jztag35 |
| authorships[13].institutions[1].type | healthcare |
| authorships[13].institutions[1].lineage | https://openalex.org/I2801228662 |
| authorships[13].institutions[1].country_code | CN |
| authorships[13].institutions[1].display_name | Peking Union Medical College Hospital |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Mengtong Xu |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Chinese Academy of Medical Sciences and Peking Union Medical College |
| authorships[14].author.id | https://openalex.org/A5091304020 |
| authorships[14].author.orcid | https://orcid.org/0000-0003-2845-0911 |
| authorships[14].author.display_name | Yan Yao |
| authorships[14].affiliations[0].raw_affiliation_string | Fuwai Hospital |
| authorships[14].author_position | last |
| authorships[14].raw_author_name | Yan Yao |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Fuwai Hospital |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.researchsquare.com/article/rs-4206914/latest.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | T Lymphocyte-Macrophage Hybrid Membrane-Coated Biomimetic Nanoparticles Alleviate Myocarditis via Suppressing Pyroptosis by Targeting Gene Silencing |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11112 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2705 |
| primary_topic.subfield.display_name | Cardiology and Cardiovascular Medicine |
| primary_topic.display_name | Viral Infections and Immunology Research |
| related_works | https://openalex.org/W3006826877, https://openalex.org/W2979508935, https://openalex.org/W819328480, https://openalex.org/W2952117239, https://openalex.org/W2270468432, https://openalex.org/W2163149544, https://openalex.org/W3090370327, https://openalex.org/W3143562902, https://openalex.org/W2171008594, https://openalex.org/W2411136628 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.21203/rs.3.rs-4206914/v1 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402450 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Research Square (Research Square) |
| best_oa_location.source.host_organization | https://openalex.org/I4210096694 |
| best_oa_location.source.host_organization_name | Research Square (United States) |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I4210096694 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.researchsquare.com/article/rs-4206914/latest.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.21203/rs.3.rs-4206914/v1 |
| primary_location.id | doi:10.21203/rs.3.rs-4206914/v1 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402450 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Research Square (Research Square) |
| primary_location.source.host_organization | https://openalex.org/I4210096694 |
| primary_location.source.host_organization_name | Research Square (United States) |
| primary_location.source.host_organization_lineage | https://openalex.org/I4210096694 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.researchsquare.com/article/rs-4206914/latest.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.21203/rs.3.rs-4206914/v1 |
| publication_date | 2024-04-09 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2890977746, https://openalex.org/W3103940138, https://openalex.org/W2165568633, https://openalex.org/W4306839866, https://openalex.org/W2111652408, https://openalex.org/W1991445486, https://openalex.org/W4285387202, https://openalex.org/W3143156272, https://openalex.org/W4306399327, https://openalex.org/W3048788919, https://openalex.org/W1985970823, https://openalex.org/W4388493942, https://openalex.org/W3123330838, https://openalex.org/W2920438880, https://openalex.org/W3121527138, https://openalex.org/W4362659823, https://openalex.org/W2889191136, https://openalex.org/W2053929414, https://openalex.org/W2145479354, https://openalex.org/W3013635432, https://openalex.org/W4323566593, https://openalex.org/W4295364795, https://openalex.org/W2770893462, https://openalex.org/W2318173837, https://openalex.org/W4388982335, https://openalex.org/W3070570833, https://openalex.org/W3031854953, https://openalex.org/W2729471090, https://openalex.org/W2139482086, https://openalex.org/W4200426115, https://openalex.org/W3117028850, https://openalex.org/W2159861093, https://openalex.org/W4283205050, https://openalex.org/W3123779494, https://openalex.org/W3028016297, https://openalex.org/W2588708434, https://openalex.org/W2478711226, https://openalex.org/W3179878281, https://openalex.org/W1993337563, https://openalex.org/W4324363258, https://openalex.org/W2488042065, https://openalex.org/W2594133976, https://openalex.org/W3105908160, https://openalex.org/W3035771130, https://openalex.org/W3042575218, https://openalex.org/W4213245349 |
| referenced_works_count | 46 |
| abstract_inverted_index.. | 127 |
| abstract_inverted_index.1 | 53 |
| abstract_inverted_index.T | 66 |
| abstract_inverted_index.a | 10, 58, 65, 100 |
| abstract_inverted_index.M1 | 90, 118 |
| abstract_inverted_index.as | 57 |
| abstract_inverted_index.by | 36 |
| abstract_inverted_index.in | 92, 122, 125, 139, 172 |
| abstract_inverted_index.of | 26, 82, 112, 129, 158, 175 |
| abstract_inverted_index.on | 45 |
| abstract_inverted_index.or | 32 |
| abstract_inverted_index.to | 29, 87, 150 |
| abstract_inverted_index.we | 48 |
| abstract_inverted_index.Our | 160 |
| abstract_inverted_index.RNA | 4 |
| abstract_inverted_index.The | 95, 110 |
| abstract_inverted_index.and | 24, 105, 124, 135, 154 |
| abstract_inverted_index.for | 6, 13, 62, 78 |
| abstract_inverted_index.the | 21, 40, 79, 88, 143, 148, 156, 164, 173 |
| abstract_inverted_index.was | 76 |
| abstract_inverted_index.IRF1 | 85, 133 |
| abstract_inverted_index.both | 121 |
| abstract_inverted_index.cell | 33 |
| abstract_inverted_index.gene | 7 |
| abstract_inverted_index.high | 101 |
| abstract_inverted_index.into | 39 |
| abstract_inverted_index.that | 163 |
| abstract_inverted_index.vivo | 123 |
| abstract_inverted_index.Based | 44 |
| abstract_inverted_index.ZIF-8 | 97 |
| abstract_inverted_index.great | 170 |
| abstract_inverted_index.holds | 169 |
| abstract_inverted_index.human | 15 |
| abstract_inverted_index.siRNA | 27, 83, 102 |
| abstract_inverted_index.small | 2 |
| abstract_inverted_index.study | 161 |
| abstract_inverted_index.vitro | 126 |
| abstract_inverted_index.escape | 38, 108 |
| abstract_inverted_index.factor | 52 |
| abstract_inverted_index.hybrid | 68, 113 |
| abstract_inverted_index.remain | 42 |
| abstract_inverted_index.siIRF1 | 130, 144 |
| abstract_inverted_index.system | 168 |
| abstract_inverted_index.target | 61 |
| abstract_inverted_index.viable | 11 |
| abstract_inverted_index.(ZIF-8) | 73 |
| abstract_inverted_index.(siRNA) | 5 |
| abstract_inverted_index.Herein, | 64 |
| abstract_inverted_index.against | 84 |
| abstract_inverted_index.coating | 115 |
| abstract_inverted_index.desired | 30 |
| abstract_inverted_index.loading | 103 |
| abstract_inverted_index.precise | 80 |
| abstract_inverted_index.reveals | 162 |
| abstract_inverted_index.tissues | 31 |
| abstract_inverted_index.(siIRF1) | 86 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Delivery | 128 |
| abstract_inverted_index.However, | 20 |
| abstract_inverted_index.ability. | 109 |
| abstract_inverted_index.approach | 146 |
| abstract_inverted_index.capacity | 104 |
| abstract_inverted_index.cytosol, | 41 |
| abstract_inverted_index.delivery | 25 |
| abstract_inverted_index.followed | 35 |
| abstract_inverted_index.improved | 117 |
| abstract_inverted_index.membrane | 114 |
| abstract_inverted_index.mitigate | 155 |
| abstract_inverted_index.platform | 75 |
| abstract_inverted_index.presents | 9 |
| abstract_inverted_index.previous | 46 |
| abstract_inverted_index.strategy | 12 |
| abstract_inverted_index.treating | 14 |
| abstract_inverted_index.zeolitic | 70 |
| abstract_inverted_index.Utilizing | 1 |
| abstract_inverted_index.attenuate | 151 |
| abstract_inverted_index.diseases, | 16 |
| abstract_inverted_index.diseases. | 177 |
| abstract_inverted_index.efficient | 106 |
| abstract_inverted_index.endosomal | 37 |
| abstract_inverted_index.exhibited | 99 |
| abstract_inverted_index.including | 17 |
| abstract_inverted_index.inhibited | 137 |
| abstract_inverted_index.potential | 59, 149 |
| abstract_inverted_index.prospects | 171 |
| abstract_inverted_index.research, | 47 |
| abstract_inverted_index.silencing | 8 |
| abstract_inverted_index.strategic | 22 |
| abstract_inverted_index.subtypes, | 34 |
| abstract_inverted_index.targeting | 23, 120 |
| abstract_inverted_index.treatment | 174 |
| abstract_inverted_index.biomimetic | 166 |
| abstract_inverted_index.conveyance | 81 |
| abstract_inverted_index.customized | 165 |
| abstract_inverted_index.disorders. | 19 |
| abstract_inverted_index.expression | 134 |
| abstract_inverted_index.fabricated | 77 |
| abstract_inverted_index.identified | 49 |
| abstract_inverted_index.interferon | 50 |
| abstract_inverted_index.macrophage | 55, 119 |
| abstract_inverted_index.myocardial | 152 |
| abstract_inverted_index.pyroptosis | 56, 138 |
| abstract_inverted_index.regulatory | 51 |
| abstract_inverted_index.suppressed | 132 |
| abstract_inverted_index.application | 111 |
| abstract_inverted_index.effectively | 131 |
| abstract_inverted_index.framework-8 | 72 |
| abstract_inverted_index.imidazolate | 71 |
| abstract_inverted_index.interfering | 3 |
| abstract_inverted_index.macrophages | 91 |
| abstract_inverted_index.myocarditis | 93 |
| abstract_inverted_index.progression | 157 |
| abstract_inverted_index.therapeutic | 60 |
| abstract_inverted_index.challenging. | 43 |
| abstract_inverted_index.demonstrated | 147 |
| abstract_inverted_index.inflammation | 153 |
| abstract_inverted_index.inflammatory | 176 |
| abstract_inverted_index.macrophages. | 141 |
| abstract_inverted_index.myocarditis. | 63, 159 |
| abstract_inverted_index.nanoparticle | 98 |
| abstract_inverted_index.therapeutics | 28 |
| abstract_inverted_index.Consequently, | 142 |
| abstract_inverted_index.concomitantly | 136 |
| abstract_inverted_index.nano-delivery | 74, 167 |
| abstract_inverted_index.siIRF1-loaded | 96 |
| abstract_inverted_index.significantly | 116 |
| abstract_inverted_index.cardiovascular | 18 |
| abstract_inverted_index.endo-lysosomal | 107 |
| abstract_inverted_index.(IRF1)-mediated | 54 |
| abstract_inverted_index.membrane-coated | 69 |
| abstract_inverted_index.nanotherapeutic | 145 |
| abstract_inverted_index.(siIRF1@ZIF@HM). | 94 |
| abstract_inverted_index.pro-inflammatory | 89 |
| abstract_inverted_index.IFN-γ-stimulated | 140 |
| abstract_inverted_index.lymphocyte-macrophage | 67 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 15 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7400000095367432 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.09686176 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |