Table S1 from Tumor Intrinsic Efficacy by SHP2 and RTK Inhibitors in KRAS-Mutant Cancers Article Swipe

View

Huai-Xiang Hao , Hongyun Wang , Chen Liu , Steven Kovats , Roberto Velazquez , Hengyu Lu , Bhavesh Pant , Matthew D. Shirley , Matthew J. Meyer , Minying Pu , Joanne Lim , Michael Fleming , LeighAnn Alexander , Ali Farsidjani , Matthew J. LaMarche , Susan E. Moody , Serena J. Silver , Giordano Caponigro , Darrin D. Stuart , Tinya J. Abrams , Peter S. Hammerman , Juliet A. Williams , Jeffrey A. Engelman , Silvia Goldoni , Morvarid Mohseni ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/1535-7163.22505916

Supplementary Table 1: List of all cell lines in the CCLE (Cancer Cell Line Encyclopedia) where sensitivity to SHP2 (PTPN11) knockdown was evaluated in 2D. Lineage, and genetic status of KRAS and BRAF are shown. Blank cells represent cell line data where genetic or sensitivity data do not exist. Values depicted are the ATARIS quantile normalized z-score. Additional details on the methodology of the screen are published (58).

Related Topics

Concepts

KRAS Cancer cell lines Gene knockdown Cancer research Cancer Medicine Biology Cell culture Internal medicine Genetics Cancer cell Colorectal cancer

Metadata

Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/1535-7163.22505916
OA Status: gold
Related Works: 10
OpenAlex ID: https://openalex.org/W4362482407

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4362482407

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1158/1535-7163.22505916

Digital Object Identifier
Title: Table S1 from Tumor Intrinsic Efficacy by SHP2 and RTK Inhibitors in KRAS-Mutant Cancers

Work title
Type: preprint

OpenAlex work type
Language: en

Primary language
Publication year: 2023

Year of publication
Publication date: 2023-04-03

Full publication date if available
Authors: Huai-Xiang Hao, Hongyun Wang, Chen Liu, Steven Kovats, Roberto Velazquez, Hengyu Lu, Bhavesh Pant, Matthew D. Shirley, Matthew J. Meyer, Minying Pu, Joanne Lim, Michael Fleming, LeighAnn Alexander, Ali Farsidjani, Matthew J. LaMarche, Susan E. Moody, Serena J. Silver, Giordano Caponigro, Darrin D. Stuart, Tinya J. Abrams, Peter S. Hammerman, Juliet A. Williams, Jeffrey A. Engelman, Silvia Goldoni, Morvarid Mohseni

List of authors in order
Landing page: https://doi.org/10.1158/1535-7163.22505916

Publisher landing page
Open access: Yes

Whether a free full text is available
OA status: gold

Open access status per OpenAlex
OA URL: https://doi.org/10.1158/1535-7163.22505916

Direct OA link when available
Concepts: KRAS, Cancer cell lines, Gene knockdown, Cancer research, Cancer, Medicine, Biology, Cell culture, Internal medicine, Genetics, Cancer cell, Colorectal cancer

Top concepts (fields/topics) attached by OpenAlex
Cited by: 0

Total citation count in OpenAlex
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4362482407
doi	https://doi.org/10.1158/1535-7163.22505916
ids.doi	https://doi.org/10.1158/1535-7163.22505916
ids.openalex	https://openalex.org/W4362482407
fwci	0.0
type	preprint
title	Table S1 from Tumor Intrinsic Efficacy by SHP2 and RTK Inhibitors in KRAS-Mutant Cancers
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
topics[0].id	https://openalex.org/T12104
topics[0].field.id	https://openalex.org/fields/13
topics[0].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[0].score	0.9991999864578247
topics[0].domain.id	https://openalex.org/domains/1
topics[0].domain.display_name	Life Sciences
topics[0].subfield.id	https://openalex.org/subfields/1312
topics[0].subfield.display_name	Molecular Biology
topics[0].display_name	Protein Tyrosine Phosphatases
topics[1].id	https://openalex.org/T10602
topics[1].field.id	https://openalex.org/fields/13
topics[1].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[1].score	0.975600004196167
topics[1].domain.id	https://openalex.org/domains/1
topics[1].domain.display_name	Life Sciences
topics[1].subfield.id	https://openalex.org/subfields/1312
topics[1].subfield.display_name	Molecular Biology
topics[1].display_name	Glycosylation and Glycoproteins Research
topics[2].id	https://openalex.org/T12387
topics[2].field.id	https://openalex.org/fields/24
topics[2].field.display_name	Immunology and Microbiology
topics[2].score	0.9661999940872192
topics[2].domain.id	https://openalex.org/domains/1
topics[2].domain.display_name	Life Sciences
topics[2].subfield.id	https://openalex.org/subfields/2403
topics[2].subfield.display_name	Immunology
topics[2].display_name	Galectins and Cancer Biology
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C2781187634
concepts[0].level	4
concepts[0].score	0.8571178317070007
concepts[0].wikidata	https://www.wikidata.org/wiki/Q20969980
concepts[0].display_name	KRAS
concepts[1].id	https://openalex.org/C2994372470
concepts[1].level	4
concepts[1].score	0.48448964953422546
concepts[1].wikidata	https://www.wikidata.org/wiki/Q4118072
concepts[1].display_name	Cancer cell lines
concepts[2].id	https://openalex.org/C173396325
concepts[2].level	3
concepts[2].score	0.45829519629478455
concepts[2].wikidata	https://www.wikidata.org/wiki/Q1501275
concepts[2].display_name	Gene knockdown
concepts[3].id	https://openalex.org/C502942594
concepts[3].level	1
concepts[3].score	0.4279518127441406
concepts[3].wikidata	https://www.wikidata.org/wiki/Q3421914
concepts[3].display_name	Cancer research
concepts[4].id	https://openalex.org/C121608353
concepts[4].level	2
concepts[4].score	0.37049806118011475
concepts[4].wikidata	https://www.wikidata.org/wiki/Q12078
concepts[4].display_name	Cancer
concepts[5].id	https://openalex.org/C71924100
concepts[5].level	0
concepts[5].score	0.360172301530838
concepts[5].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[5].display_name	Medicine
concepts[6].id	https://openalex.org/C86803240
concepts[6].level	0
concepts[6].score	0.3494340777397156
concepts[6].wikidata	https://www.wikidata.org/wiki/Q420
concepts[6].display_name	Biology
concepts[7].id	https://openalex.org/C81885089
concepts[7].level	2
concepts[7].score	0.3150576949119568
concepts[7].wikidata	https://www.wikidata.org/wiki/Q189082
concepts[7].display_name	Cell culture
concepts[8].id	https://openalex.org/C126322002
concepts[8].level	1
concepts[8].score	0.2891540825366974
concepts[8].wikidata	https://www.wikidata.org/wiki/Q11180
concepts[8].display_name	Internal medicine
concepts[9].id	https://openalex.org/C54355233
concepts[9].level	1
concepts[9].score	0.26116234064102173
concepts[9].wikidata	https://www.wikidata.org/wiki/Q7162
concepts[9].display_name	Genetics
concepts[10].id	https://openalex.org/C96232424
concepts[10].level	3
concepts[10].score	0.15771722793579102
concepts[10].wikidata	https://www.wikidata.org/wiki/Q4118072
concepts[10].display_name	Cancer cell
concepts[11].id	https://openalex.org/C526805850
concepts[11].level	3
concepts[11].score	0.0
concepts[11].wikidata	https://www.wikidata.org/wiki/Q188874
concepts[11].display_name	Colorectal cancer
keywords[0].id	https://openalex.org/keywords/kras
keywords[0].score	0.8571178317070007
keywords[0].display_name	KRAS
keywords[1].id	https://openalex.org/keywords/cancer-cell-lines
keywords[1].score	0.48448964953422546
keywords[1].display_name	Cancer cell lines
keywords[2].id	https://openalex.org/keywords/gene-knockdown
keywords[2].score	0.45829519629478455
keywords[2].display_name	Gene knockdown
keywords[3].id	https://openalex.org/keywords/cancer-research
keywords[3].score	0.4279518127441406
keywords[3].display_name	Cancer research
keywords[4].id	https://openalex.org/keywords/cancer
keywords[4].score	0.37049806118011475
keywords[4].display_name	Cancer
keywords[5].id	https://openalex.org/keywords/medicine
keywords[5].score	0.360172301530838
keywords[5].display_name	Medicine
keywords[6].id	https://openalex.org/keywords/biology
keywords[6].score	0.3494340777397156
keywords[6].display_name	Biology
keywords[7].id	https://openalex.org/keywords/cell-culture
keywords[7].score	0.3150576949119568
keywords[7].display_name	Cell culture
keywords[8].id	https://openalex.org/keywords/internal-medicine
keywords[8].score	0.2891540825366974
keywords[8].display_name	Internal medicine
keywords[9].id	https://openalex.org/keywords/genetics
keywords[9].score	0.26116234064102173
keywords[9].display_name	Genetics
keywords[10].id	https://openalex.org/keywords/cancer-cell
keywords[10].score	0.15771722793579102
keywords[10].display_name	Cancer cell
language	en
locations[0].id	doi:10.1158/1535-7163.22505916
locations[0].is_oa	True
locations[0].source
locations[0].license	cc-by
locations[0].pdf_url
locations[0].version	acceptedVersion
locations[0].raw_type	posted-content
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	https://doi.org/10.1158/1535-7163.22505916
indexed_in	crossref
authorships[0].author.id	https://openalex.org/A5049400334
authorships[0].author.orcid
authorships[0].author.display_name	Huai-Xiang Hao
authorships[0].author_position	first
authorships[0].raw_author_name	Huai-Xiang Hao
authorships[0].is_corresponding	False
authorships[1].author.id	https://openalex.org/A5034804463
authorships[1].author.orcid	https://orcid.org/0000-0001-5169-7387
authorships[1].author.display_name	Hongyun Wang
authorships[1].author_position	middle
authorships[1].raw_author_name	Hongyun Wang
authorships[1].is_corresponding	False
authorships[2].author.id	https://openalex.org/A5100322216
authorships[2].author.orcid	https://orcid.org/0009-0003-0430-6146
authorships[2].author.display_name	Chen Liu
authorships[2].author_position	middle
authorships[2].raw_author_name	Chen Liu
authorships[2].is_corresponding	False
authorships[3].author.id	https://openalex.org/A5067698369
authorships[3].author.orcid
authorships[3].author.display_name	Steven Kovats
authorships[3].author_position	middle
authorships[3].raw_author_name	Steven Kovats
authorships[3].is_corresponding	False
authorships[4].author.id	https://openalex.org/A5022940770
authorships[4].author.orcid	https://orcid.org/0000-0002-2008-3654
authorships[4].author.display_name	Roberto Velazquez
authorships[4].author_position	middle
authorships[4].raw_author_name	Roberto Velazquez
authorships[4].is_corresponding	False
authorships[5].author.id	https://openalex.org/A5112085916
authorships[5].author.orcid
authorships[5].author.display_name	Hengyu Lu
authorships[5].author_position	middle
authorships[5].raw_author_name	Hengyu Lu
authorships[5].is_corresponding	False
authorships[6].author.id	https://openalex.org/A5060001183
authorships[6].author.orcid	https://orcid.org/0000-0002-7053-3481
authorships[6].author.display_name	Bhavesh Pant
authorships[6].author_position	middle
authorships[6].raw_author_name	Bhavesh Pant
authorships[6].is_corresponding	False
authorships[7].author.id	https://openalex.org/A5017572224
authorships[7].author.orcid	https://orcid.org/0000-0003-0855-9274
authorships[7].author.display_name	Matthew D. Shirley
authorships[7].author_position	middle
authorships[7].raw_author_name	Matthew Shirley
authorships[7].is_corresponding	False
authorships[8].author.id	https://openalex.org/A5006564877
authorships[8].author.orcid	https://orcid.org/0000-0003-4486-3214
authorships[8].author.display_name	Matthew J. Meyer
authorships[8].author_position	middle
authorships[8].raw_author_name	Matthew J. Meyer
authorships[8].is_corresponding	False
authorships[9].author.id	https://openalex.org/A5086522167
authorships[9].author.orcid
authorships[9].author.display_name	Minying Pu
authorships[9].author_position	middle
authorships[9].raw_author_name	Minying Pu
authorships[9].is_corresponding	False
authorships[10].author.id	https://openalex.org/A5084946395
authorships[10].author.orcid	https://orcid.org/0000-0002-1326-8634
authorships[10].author.display_name	Joanne Lim
authorships[10].author_position	middle
authorships[10].raw_author_name	Joanne Lim
authorships[10].is_corresponding	False
authorships[11].author.id	https://openalex.org/A5049907850
authorships[11].author.orcid	https://orcid.org/0000-0002-2185-4502
authorships[11].author.display_name	Michael Fleming
authorships[11].author_position	middle
authorships[11].raw_author_name	Michael Fleming
authorships[11].is_corresponding	False
authorships[12].author.id	https://openalex.org/A5032231175
authorships[12].author.orcid
authorships[12].author.display_name	LeighAnn Alexander
authorships[12].author_position	middle
authorships[12].raw_author_name	LeighAnn Alexander
authorships[12].is_corresponding	False
authorships[13].author.id	https://openalex.org/A5084193116
authorships[13].author.orcid
authorships[13].author.display_name	Ali Farsidjani
authorships[13].author_position	middle
authorships[13].raw_author_name	Ali Farsidjani
authorships[13].is_corresponding	False
authorships[14].author.id	https://openalex.org/A5041672891
authorships[14].author.orcid	https://orcid.org/0000-0002-6588-2302
authorships[14].author.display_name	Matthew J. LaMarche
authorships[14].author_position	middle
authorships[14].raw_author_name	Matthew J. LaMarche
authorships[14].is_corresponding	False
authorships[15].author.id	https://openalex.org/A5054375076
authorships[15].author.orcid	https://orcid.org/0009-0002-7714-1170
authorships[15].author.display_name	Susan E. Moody
authorships[15].author_position	middle
authorships[15].raw_author_name	Susan Moody
authorships[15].is_corresponding	False
authorships[16].author.id	https://openalex.org/A5042569887
authorships[16].author.orcid	https://orcid.org/0000-0001-8090-2941
authorships[16].author.display_name	Serena J. Silver
authorships[16].author_position	middle
authorships[16].raw_author_name	Serena J. Silver
authorships[16].is_corresponding	False
authorships[17].author.id	https://openalex.org/A5025118565
authorships[17].author.orcid
authorships[17].author.display_name	Giordano Caponigro
authorships[17].author_position	middle
authorships[17].raw_author_name	Giordano Caponigro
authorships[17].is_corresponding	False
authorships[18].author.id	https://openalex.org/A5049772515
authorships[18].author.orcid	https://orcid.org/0000-0002-4666-4000
authorships[18].author.display_name	Darrin D. Stuart
authorships[18].author_position	middle
authorships[18].raw_author_name	Darrin D. Stuart
authorships[18].is_corresponding	False
authorships[19].author.id	https://openalex.org/A5091240262
authorships[19].author.orcid
authorships[19].author.display_name	Tinya J. Abrams
authorships[19].author_position	middle
authorships[19].raw_author_name	Tinya J. Abrams
authorships[19].is_corresponding	False
authorships[20].author.id	https://openalex.org/A5004171995
authorships[20].author.orcid	https://orcid.org/0009-0006-9143-899X
authorships[20].author.display_name	Peter S. Hammerman
authorships[20].author_position	middle
authorships[20].raw_author_name	Peter S. Hammerman
authorships[20].is_corresponding	False
authorships[21].author.id	https://openalex.org/A5004972144
authorships[21].author.orcid	https://orcid.org/0000-0002-9019-9812
authorships[21].author.display_name	Juliet A. Williams
authorships[21].author_position	middle
authorships[21].raw_author_name	Juliet Williams
authorships[21].is_corresponding	False
authorships[22].author.id	https://openalex.org/A5040093136
authorships[22].author.orcid	https://orcid.org/0009-0004-0775-4523
authorships[22].author.display_name	Jeffrey A. Engelman
authorships[22].author_position	middle
authorships[22].raw_author_name	Jeffrey A. Engelman
authorships[22].is_corresponding	False
authorships[23].author.id	https://openalex.org/A5005515075
authorships[23].author.orcid
authorships[23].author.display_name	Silvia Goldoni
authorships[23].author_position	middle
authorships[23].raw_author_name	Silvia Goldoni
authorships[23].is_corresponding	False
authorships[24].author.id	https://openalex.org/A5046896380
authorships[24].author.orcid	https://orcid.org/0000-0002-0964-924X
authorships[24].author.display_name	Morvarid Mohseni
authorships[24].author_position	last
authorships[24].raw_author_name	Morvarid Mohseni
authorships[24].is_corresponding	False
has_content.pdf	False
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://doi.org/10.1158/1535-7163.22505916
open_access.oa_status	gold
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Table S1 from Tumor Intrinsic Efficacy by SHP2 and RTK Inhibitors in KRAS-Mutant Cancers
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T12104
primary_topic.field.id	https://openalex.org/fields/13
primary_topic.field.display_name	Biochemistry, Genetics and Molecular Biology
primary_topic.score	0.9991999864578247
primary_topic.domain.id	https://openalex.org/domains/1
primary_topic.domain.display_name	Life Sciences
primary_topic.subfield.id	https://openalex.org/subfields/1312
primary_topic.subfield.display_name	Molecular Biology
primary_topic.display_name	Protein Tyrosine Phosphatases
related_works	https://openalex.org/W3030972949, https://openalex.org/W4306404900, https://openalex.org/W1686926070, https://openalex.org/W3204273758, https://openalex.org/W4367603427, https://openalex.org/W3093086801, https://openalex.org/W1564105650, https://openalex.org/W2965386709, https://openalex.org/W2405593806, https://openalex.org/W4242472523
cited_by_count	0
locations_count	1
best_oa_location.id	doi:10.1158/1535-7163.22505916
best_oa_location.is_oa	True
best_oa_location.source
best_oa_location.license	cc-by
best_oa_location.pdf_url
best_oa_location.version	acceptedVersion
best_oa_location.raw_type	posted-content
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	https://doi.org/10.1158/1535-7163.22505916
primary_location.id	doi:10.1158/1535-7163.22505916
primary_location.is_oa	True
primary_location.source
primary_location.license	cc-by
primary_location.pdf_url
primary_location.version	acceptedVersion
primary_location.raw_type	posted-content
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	https://doi.org/10.1158/1535-7163.22505916
publication_date	2023-04-03
publication_year	2023
referenced_works_count	0
abstract_inverted_index.1:	2
abstract_inverted_index.do	46
abstract_inverted_index.in	8, 23
abstract_inverted_index.of	4, 29, 62
abstract_inverted_index.on	59
abstract_inverted_index.or	43
abstract_inverted_index.to	17
abstract_inverted_index.2D.	24
abstract_inverted_index.all	5
abstract_inverted_index.and	26, 31
abstract_inverted_index.are	33, 51, 65
abstract_inverted_index.not	47
abstract_inverted_index.the	9, 52, 60, 63
abstract_inverted_index.was	21
abstract_inverted_index.BRAF	32
abstract_inverted_index.CCLE	10
abstract_inverted_index.Cell	12
abstract_inverted_index.KRAS	30
abstract_inverted_index.Line	13
abstract_inverted_index.List	3
abstract_inverted_index.SHP2	18
abstract_inverted_index.cell	6, 38
abstract_inverted_index.data	40, 45
abstract_inverted_index.line	39
abstract_inverted_index.Blank	35
abstract_inverted_index.Table	1
abstract_inverted_index.cells	36
abstract_inverted_index.lines	7
abstract_inverted_index.where	15, 41
abstract_inverted_index.ATARIS	53
abstract_inverted_index.Values	49
abstract_inverted_index.exist.	48
abstract_inverted_index.screen	64
abstract_inverted_index.shown.	34
abstract_inverted_index.status	28
abstract_inverted_index.(Cancer	11
abstract_inverted_index.details	58
abstract_inverted_index.genetic	27, 42
abstract_inverted_index.(PTPN11)	19
abstract_inverted_index.Lineage,	25
abstract_inverted_index.depicted	50
abstract_inverted_index.quantile	54
abstract_inverted_index.z-score.	56
abstract_inverted_index.evaluated	22
abstract_inverted_index.knockdown	20
abstract_inverted_index.published	66
abstract_inverted_index.represent	37
abstract_inverted_index.Additional	57
abstract_inverted_index.normalized	55
abstract_inverted_index.methodology	61
abstract_inverted_index.sensitivity	16, 44
abstract_inverted_index.Encyclopedia)	14
abstract_inverted_index.(58).</p>	67
abstract_inverted_index.<p>Supplementary	0
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	25
sustainable_development_goals[0].id	https://metadata.un.org/sdg/3
sustainable_development_goals[0].score	0.7099999785423279
sustainable_development_goals[0].display_name	Good health and well-being
citation_normalized_percentile.value	0.16433406
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False