Tamarind Seed Polysaccharide Hydrolysate Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis via Regulating the Gut Microbiota Article Swipe
Kangjia Jiang
,
Duo Wang
,
Le Su
,
Xinli Liu
,
Qiulin Yue
,
Song Zhang
,
Lin Zhao
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ph16081133
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ph16081133
(1) Background: Ulcerative colitis (UC) is a disease caused by noninfectious chronic inflammation characterized by varying degrees of inflammation affecting the colon or its entire mucosal surface. Current therapeutic strategies rely on the suppression of the immune response, which is effective, but can have detrimental effects. Recently, different plant polysaccharides and their degradation products have received increasing attention due to their prominent biological activities. The aim of this research was to evaluate the mitigation of inflammation exhibited by tamarind seed polysaccharide hydrolysate (TSPH) ingestion in colitis mice. (2) Methods: TSPH was obtained from the hydrolysis of tamarind seed polysaccharide (TSP) by trifluoroacetic acid (TFA). The structure and physical properties of TSPH were characterized by ultraviolet spectroscopy (UV), thin-layer chromatography (TLC), fourier transform infrared spectroscopy (FT-IR), and High-Performance Liquid Chromatography and Electrospray Ionization Mass Spectrometry (HPLC–ESI/MS) analysis. Then, the alleviative effects of the action of TSPH on 2.5% dextran sodium sulfate (DSS)-induced colitis mice were investigated. (3) Results: TSPH restored pathological lesions in the colon and inhibited the over-secretion of pro-inflammatory cytokines in UC mice. The relative expression level of mRNA for colonic tight junction proteins was increased. These findings suggested that TSPH could reduce inflammation in the colon. Additionally, the structure of the gut microbiota was also altered, with beneficial bacteria, including Prevotella and Blautia, significantly enriched by TSPH. Moreover, the richness of Blautia was positively correlated with acetic acid. (4) Conclusions: In conclusion, TSPH suppressed colonic inflammation, alleviated imbalances in the intestinal flora and regulated bacterial metabolites. Thus, this also implies that TSPH has the potential to be a functional food against colitis.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ph16081133
- https://www.mdpi.com/1424-8247/16/8/1133/pdf?version=1691665184
- OA Status
- gold
- Cited By
- 6
- References
- 64
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4385741073
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4385741073Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ph16081133Digital Object Identifier
- Title
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Tamarind Seed Polysaccharide Hydrolysate Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis via Regulating the Gut MicrobiotaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-08-10Full publication date if available
- Authors
-
Kangjia Jiang, Duo Wang, Le Su, Xinli Liu, Qiulin Yue, Song Zhang, Lin ZhaoList of authors in order
- Landing page
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https://doi.org/10.3390/ph16081133Publisher landing page
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https://www.mdpi.com/1424-8247/16/8/1133/pdf?version=1691665184Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1424-8247/16/8/1133/pdf?version=1691665184Direct OA link when available
- Concepts
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Ulcerative colitis, Colitis, Inflammation, Chemistry, Hydrolysate, Polysaccharide, Inflammatory bowel disease, Gut flora, Microbiology, Carrageenan, Pharmacology, Biochemistry, Hydrolysis, Immunology, Medicine, Biology, Internal medicine, DiseaseTop concepts (fields/topics) attached by OpenAlex
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6Total citation count in OpenAlex
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2025: 4, 2024: 1, 2023: 1Per-year citation counts (last 5 years)
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64Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.investigated. | 154 |
| abstract_inverted_index.noninfectious | 10 |
| abstract_inverted_index.significantly | 215 |
| abstract_inverted_index.Chromatography | 128 |
| abstract_inverted_index.chromatography | 118 |
| abstract_inverted_index.over-secretion | 167 |
| abstract_inverted_index.polysaccharide | 80, 98 |
| abstract_inverted_index.(HPLC–ESI/MS) | 134 |
| abstract_inverted_index.polysaccharides | 49 |
| abstract_inverted_index.trifluoroacetic | 101 |
| abstract_inverted_index.High-Performance | 126 |
| abstract_inverted_index.pro-inflammatory | 169 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5100366521, https://openalex.org/A5015565945 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I152269853, https://openalex.org/I4210142748 |
| citation_normalized_percentile.value | 0.78315228 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |