Targeted Analysis of the Size Distribution of Heavy Chain-Modified Hyaluronan with Solid-State Nanopores Article Swipe
Dorothea Erxleben
,
Rebecca J. Dodd
,
Anthony J. Day
,
Dixy E. Green
,
Paul L. DeAngelis
,
Suruchi Poddar
,
Jan J. Enghild
,
Janet L. Huebner
,
Virginia B. Kraus
,
Amanda Watkins
,
Heidi L. Reesink
,
Elaheh Rahbar
,
Adam R. Hall
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1021/acs.analchem.3c04387
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1021/acs.analchem.3c04387
The glycosaminoglycan hyaluronan (HA) plays important roles in diverse physiological functions where the distribution of its molecular weight (MW) can influence its behavior and is known to change in response to disease conditions. During inflammation, HA undergoes a covalent modification in which heavy chain subunits of the inter-alpha-inhibitor family of proteins are transferred to its structure, forming heavy chain-HA (HC•HA) complexes. While limited assessments of HC•HA have been performed previously, determining the size distribution of its HA component remains a challenge. Here, we describe a selective method for extracting HC•HA from mixtures that yields material amenable to MW analysis with a solid-state nanopore sensor. After demonstrating the approach in vitro, we validate extraction of HC•HA from osteoarthritic human synovial fluid as a model complex biological matrix. Finally, we apply our technique to pathophysiology by measuring the size distributions of HC•HA and total HA in an equine model of synovitis.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acs.analchem.3c04387
- OA Status
- green
- Cited By
- 8
- References
- 83
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390823925
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4390823925Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1021/acs.analchem.3c04387Digital Object Identifier
- Title
-
Targeted Analysis of the Size Distribution of Heavy Chain-Modified Hyaluronan with Solid-State NanoporesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-01-12Full publication date if available
- Authors
-
Dorothea Erxleben, Rebecca J. Dodd, Anthony J. Day, Dixy E. Green, Paul L. DeAngelis, Suruchi Poddar, Jan J. Enghild, Janet L. Huebner, Virginia B. Kraus, Amanda Watkins, Heidi L. Reesink, Elaheh Rahbar, Adam R. HallList of authors in order
- Landing page
-
https://doi.org/10.1021/acs.analchem.3c04387Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/11037269Direct OA link when available
- Concepts
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Chemistry, Nanopore, Hyaluronic acid, Glycosaminoglycan, Matrix (chemical analysis), Biophysics, Extracellular matrix, Chromatography, Chemical engineering, Biochemistry, Biology, Genetics, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
8Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 7Per-year citation counts (last 5 years)
- References (count)
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83Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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