Targeting androgen receptor and the variants by an orally bioavailable Proteolysis Targeting Chimeras compound in castration resistant prostate cancer Article Swipe
Chiu-Lien Hung
,
Hao-Hsuan Liu
,
Chih‐Wei Fu
,
Hsun-Hao Yeh
,
Tsan-Lin Hu
,
Zong‐Keng Kuo
,
Yu-Chin Lin
,
Mei-Ru Jhang
,
Chrong-Shiong Hwang
,
Hung‐Chih Hsu
,
Hsing‐Jien Kung
,
Ling‐Yu Wang
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.ebiom.2023.104500
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.ebiom.2023.104500
Related Topics
Concepts
Enzalutamide
Androgen receptor
Prostate cancer
Cancer research
Transactivation
Ubiquitin ligase
Bicalutamide
Androgen
Chemistry
Biology
Pharmacology
Ubiquitin
Cancer
Transcription factor
Biochemistry
Hormone
Genetics
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.ebiom.2023.104500
- OA Status
- gold
- Cited By
- 30
- References
- 64
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4323363591
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4323363591Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.ebiom.2023.104500Digital Object Identifier
- Title
-
Targeting androgen receptor and the variants by an orally bioavailable Proteolysis Targeting Chimeras compound in castration resistant prostate cancerWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-03-06Full publication date if available
- Authors
-
Chiu-Lien Hung, Hao-Hsuan Liu, Chih‐Wei Fu, Hsun-Hao Yeh, Tsan-Lin Hu, Zong‐Keng Kuo, Yu-Chin Lin, Mei-Ru Jhang, Chrong-Shiong Hwang, Hung‐Chih Hsu, Hsing‐Jien Kung, Ling‐Yu WangList of authors in order
- Landing page
-
https://doi.org/10.1016/j.ebiom.2023.104500Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1016/j.ebiom.2023.104500Direct OA link when available
- Concepts
-
Enzalutamide, Androgen receptor, Prostate cancer, Cancer research, Transactivation, Ubiquitin ligase, Bicalutamide, Androgen, Chemistry, Biology, Pharmacology, Ubiquitin, Cancer, Transcription factor, Biochemistry, Hormone, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
30Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 9, 2024: 15, 2023: 6Per-year citation counts (last 5 years)
- References (count)
-
64Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4323363591 |
|---|---|
| doi | https://doi.org/10.1016/j.ebiom.2023.104500 |
| ids.doi | https://doi.org/10.1016/j.ebiom.2023.104500 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/36893587 |
| ids.openalex | https://openalex.org/W4323363591 |
| fwci | 5.57011223 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D008297 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Male |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D006801 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Humans |
| mesh[2].qualifier_ui | Q000235 |
| mesh[2].descriptor_ui | D011944 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | genetics |
| mesh[2].descriptor_name | Receptors, Androgen |
| mesh[3].qualifier_ui | Q000378 |
| mesh[3].descriptor_ui | D011944 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | metabolism |
| mesh[3].descriptor_name | Receptors, Androgen |
| mesh[4].qualifier_ui | Q000188 |
| mesh[4].descriptor_ui | D064129 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | drug therapy |
| mesh[4].descriptor_name | Prostatic Neoplasms, Castration-Resistant |
| mesh[5].qualifier_ui | Q000235 |
| mesh[5].descriptor_ui | D064129 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | genetics |
| mesh[5].descriptor_name | Prostatic Neoplasms, Castration-Resistant |
| mesh[6].qualifier_ui | Q000378 |
| mesh[6].descriptor_ui | D064129 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | metabolism |
| mesh[6].descriptor_name | Prostatic Neoplasms, Castration-Resistant |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D000094243 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Proteolysis Targeting Chimera |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D008024 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Ligands |
| mesh[9].qualifier_ui | Q000627 |
| mesh[9].descriptor_ui | D009570 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | therapeutic use |
| mesh[9].descriptor_name | Nitriles |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D045744 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Cell Line, Tumor |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D059748 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Proteolysis |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D008297 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Male |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D006801 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Humans |
| mesh[14].qualifier_ui | Q000235 |
| mesh[14].descriptor_ui | D011944 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | genetics |
| mesh[14].descriptor_name | Receptors, Androgen |
| mesh[15].qualifier_ui | Q000378 |
| mesh[15].descriptor_ui | D011944 |
| mesh[15].is_major_topic | True |
| mesh[15].qualifier_name | metabolism |
| mesh[15].descriptor_name | Receptors, Androgen |
| mesh[16].qualifier_ui | Q000188 |
| mesh[16].descriptor_ui | D064129 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | drug therapy |
| mesh[16].descriptor_name | Prostatic Neoplasms, Castration-Resistant |
| mesh[17].qualifier_ui | Q000235 |
| mesh[17].descriptor_ui | D064129 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | genetics |
| mesh[17].descriptor_name | Prostatic Neoplasms, Castration-Resistant |
| mesh[18].qualifier_ui | Q000378 |
| mesh[18].descriptor_ui | D064129 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | metabolism |
| mesh[18].descriptor_name | Prostatic Neoplasms, Castration-Resistant |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D000094243 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Proteolysis Targeting Chimera |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D008024 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Ligands |
| mesh[21].qualifier_ui | Q000627 |
| mesh[21].descriptor_ui | D009570 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | therapeutic use |
| mesh[21].descriptor_name | Nitriles |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D045744 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Cell Line, Tumor |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D059748 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Proteolysis |
| type | article |
| title | Targeting androgen receptor and the variants by an orally bioavailable Proteolysis Targeting Chimeras compound in castration resistant prostate cancer |
| biblio.issue | |
| biblio.volume | 90 |
| biblio.last_page | 104500 |
| biblio.first_page | 104500 |
| topics[0].id | https://openalex.org/T12534 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Protein Degradation and Inhibitors |
| topics[1].id | https://openalex.org/T10543 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9997000098228455 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2740 |
| topics[1].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[1].display_name | Prostate Cancer Treatment and Research |
| topics[2].id | https://openalex.org/T10649 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9993000030517578 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2720 |
| topics[2].subfield.display_name | Hematology |
| topics[2].display_name | Multiple Myeloma Research and Treatments |
| is_xpac | False |
| apc_list.value | 3500 |
| apc_list.currency | USD |
| apc_list.value_usd | 3500 |
| apc_paid.value | 3500 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 3500 |
| concepts[0].id | https://openalex.org/C2776551883 |
| concepts[0].level | 5 |
| concepts[0].score | 0.936984121799469 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1996756 |
| concepts[0].display_name | Enzalutamide |
| concepts[1].id | https://openalex.org/C61367390 |
| concepts[1].level | 4 |
| concepts[1].score | 0.8645537495613098 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q416601 |
| concepts[1].display_name | Androgen receptor |
| concepts[2].id | https://openalex.org/C2780192828 |
| concepts[2].level | 3 |
| concepts[2].score | 0.7595937252044678 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q181257 |
| concepts[2].display_name | Prostate cancer |
| concepts[3].id | https://openalex.org/C502942594 |
| concepts[3].level | 1 |
| concepts[3].score | 0.6491936445236206 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[3].display_name | Cancer research |
| concepts[4].id | https://openalex.org/C1292079 |
| concepts[4].level | 4 |
| concepts[4].score | 0.628501832485199 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q3817769 |
| concepts[4].display_name | Transactivation |
| concepts[5].id | https://openalex.org/C134459356 |
| concepts[5].level | 4 |
| concepts[5].score | 0.5309723615646362 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q4274835 |
| concepts[5].display_name | Ubiquitin ligase |
| concepts[6].id | https://openalex.org/C2780962315 |
| concepts[6].level | 5 |
| concepts[6].score | 0.4768970012664795 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q1988832 |
| concepts[6].display_name | Bicalutamide |
| concepts[7].id | https://openalex.org/C2777911890 |
| concepts[7].level | 3 |
| concepts[7].score | 0.44303274154663086 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q62614 |
| concepts[7].display_name | Androgen |
| concepts[8].id | https://openalex.org/C185592680 |
| concepts[8].level | 0 |
| concepts[8].score | 0.42852646112442017 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[8].display_name | Chemistry |
| concepts[9].id | https://openalex.org/C86803240 |
| concepts[9].level | 0 |
| concepts[9].score | 0.37674853205680847 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[9].display_name | Biology |
| concepts[10].id | https://openalex.org/C98274493 |
| concepts[10].level | 1 |
| concepts[10].score | 0.3509882092475891 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[10].display_name | Pharmacology |
| concepts[11].id | https://openalex.org/C25602115 |
| concepts[11].level | 3 |
| concepts[11].score | 0.34156835079193115 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q407111 |
| concepts[11].display_name | Ubiquitin |
| concepts[12].id | https://openalex.org/C121608353 |
| concepts[12].level | 2 |
| concepts[12].score | 0.28667253255844116 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[12].display_name | Cancer |
| concepts[13].id | https://openalex.org/C86339819 |
| concepts[13].level | 3 |
| concepts[13].score | 0.17549267411231995 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q407384 |
| concepts[13].display_name | Transcription factor |
| concepts[14].id | https://openalex.org/C55493867 |
| concepts[14].level | 1 |
| concepts[14].score | 0.15629947185516357 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[14].display_name | Biochemistry |
| concepts[15].id | https://openalex.org/C71315377 |
| concepts[15].level | 2 |
| concepts[15].score | 0.12866798043251038 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q11364 |
| concepts[15].display_name | Hormone |
| concepts[16].id | https://openalex.org/C54355233 |
| concepts[16].level | 1 |
| concepts[16].score | 0.11594784259796143 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[16].display_name | Genetics |
| concepts[17].id | https://openalex.org/C104317684 |
| concepts[17].level | 2 |
| concepts[17].score | 0.09389510750770569 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[17].display_name | Gene |
| keywords[0].id | https://openalex.org/keywords/enzalutamide |
| keywords[0].score | 0.936984121799469 |
| keywords[0].display_name | Enzalutamide |
| keywords[1].id | https://openalex.org/keywords/androgen-receptor |
| keywords[1].score | 0.8645537495613098 |
| keywords[1].display_name | Androgen receptor |
| keywords[2].id | https://openalex.org/keywords/prostate-cancer |
| keywords[2].score | 0.7595937252044678 |
| keywords[2].display_name | Prostate cancer |
| keywords[3].id | https://openalex.org/keywords/cancer-research |
| keywords[3].score | 0.6491936445236206 |
| keywords[3].display_name | Cancer research |
| keywords[4].id | https://openalex.org/keywords/transactivation |
| keywords[4].score | 0.628501832485199 |
| keywords[4].display_name | Transactivation |
| keywords[5].id | https://openalex.org/keywords/ubiquitin-ligase |
| keywords[5].score | 0.5309723615646362 |
| keywords[5].display_name | Ubiquitin ligase |
| keywords[6].id | https://openalex.org/keywords/bicalutamide |
| keywords[6].score | 0.4768970012664795 |
| keywords[6].display_name | Bicalutamide |
| keywords[7].id | https://openalex.org/keywords/androgen |
| keywords[7].score | 0.44303274154663086 |
| keywords[7].display_name | Androgen |
| keywords[8].id | https://openalex.org/keywords/chemistry |
| keywords[8].score | 0.42852646112442017 |
| keywords[8].display_name | Chemistry |
| keywords[9].id | https://openalex.org/keywords/biology |
| keywords[9].score | 0.37674853205680847 |
| keywords[9].display_name | Biology |
| keywords[10].id | https://openalex.org/keywords/pharmacology |
| keywords[10].score | 0.3509882092475891 |
| keywords[10].display_name | Pharmacology |
| keywords[11].id | https://openalex.org/keywords/ubiquitin |
| keywords[11].score | 0.34156835079193115 |
| keywords[11].display_name | Ubiquitin |
| keywords[12].id | https://openalex.org/keywords/cancer |
| keywords[12].score | 0.28667253255844116 |
| keywords[12].display_name | Cancer |
| keywords[13].id | https://openalex.org/keywords/transcription-factor |
| keywords[13].score | 0.17549267411231995 |
| keywords[13].display_name | Transcription factor |
| keywords[14].id | https://openalex.org/keywords/biochemistry |
| keywords[14].score | 0.15629947185516357 |
| keywords[14].display_name | Biochemistry |
| keywords[15].id | https://openalex.org/keywords/hormone |
| keywords[15].score | 0.12866798043251038 |
| keywords[15].display_name | Hormone |
| keywords[16].id | https://openalex.org/keywords/genetics |
| keywords[16].score | 0.11594784259796143 |
| keywords[16].display_name | Genetics |
| keywords[17].id | https://openalex.org/keywords/gene |
| keywords[17].score | 0.09389510750770569 |
| keywords[17].display_name | Gene |
| language | en |
| locations[0].id | doi:10.1016/j.ebiom.2023.104500 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2531685872 |
| locations[0].source.issn | 2352-3964 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2352-3964 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | EBioMedicine |
| locations[0].source.host_organization | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_name | Elsevier BV |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320990 |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | eBioMedicine |
| locations[0].landing_page_url | https://doi.org/10.1016/j.ebiom.2023.104500 |
| locations[1].id | pmid:36893587 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | EBioMedicine |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/36893587 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:10011747 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10011747/pdf/main.pdf |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | eBioMedicine |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10011747 |
| locations[3].id | pmh:oai:doaj.org/article:261dfea0757d4c98a4f29cb07cc5898e |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].source.host_organization_lineage | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | EBioMedicine, Vol 90, Iss , Pp 104500- (2023) |
| locations[3].landing_page_url | https://doaj.org/article/261dfea0757d4c98a4f29cb07cc5898e |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5113741605 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Chiu-Lien Hung |
| authorships[0].countries | TW |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210148468 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Preclinical Drug Discovery Technology, Biomedical Technology and Devices Research Labs, Industrial Technology Research Institute, Hsinchu 31040, Taiwan. |
| authorships[0].institutions[0].id | https://openalex.org/I4210148468 |
| authorships[0].institutions[0].ror | https://ror.org/05szzwt63 |
| authorships[0].institutions[0].type | nonprofit |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210148468 |
| authorships[0].institutions[0].country_code | TW |
| authorships[0].institutions[0].display_name | Industrial Technology Research Institute |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Chiu-Lien Hung |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Preclinical Drug Discovery Technology, Biomedical Technology and Devices Research Labs, Industrial Technology Research Institute, Hsinchu 31040, Taiwan. |
| authorships[1].author.id | https://openalex.org/A5081356738 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Hao-Hsuan Liu |
| authorships[1].countries | TW |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210148468 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Preclinical Drug Discovery Technology, Biomedical Technology and Devices Research Labs, Industrial Technology Research Institute, Hsinchu 31040, Taiwan. |
| authorships[1].institutions[0].id | https://openalex.org/I4210148468 |
| authorships[1].institutions[0].ror | https://ror.org/05szzwt63 |
| authorships[1].institutions[0].type | nonprofit |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210148468 |
| authorships[1].institutions[0].country_code | TW |
| authorships[1].institutions[0].display_name | Industrial Technology Research Institute |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Hao-Hsuan Liu |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Preclinical Drug Discovery Technology, Biomedical Technology and Devices Research Labs, Industrial Technology Research Institute, Hsinchu 31040, Taiwan. |
| authorships[2].author.id | https://openalex.org/A5080898641 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-2334-0302 |
| authorships[2].author.display_name | Chih‐Wei Fu |
| authorships[2].countries | TW |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210148468 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Preclinical Drug Discovery Technology, Biomedical Technology and Devices Research Labs, Industrial Technology Research Institute, Hsinchu 31040, Taiwan. |
| authorships[2].institutions[0].id | https://openalex.org/I4210148468 |
| authorships[2].institutions[0].ror | https://ror.org/05szzwt63 |
| authorships[2].institutions[0].type | nonprofit |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210148468 |
| authorships[2].institutions[0].country_code | TW |
| authorships[2].institutions[0].display_name | Industrial Technology Research Institute |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Chih-Wei Fu |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Preclinical Drug Discovery Technology, Biomedical Technology and Devices Research Labs, Industrial Technology Research Institute, Hsinchu 31040, Taiwan. |
| authorships[3].author.id | https://openalex.org/A5007329194 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Hsun-Hao Yeh |
| authorships[3].countries | TW |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I173093425 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Biochemistry and Molecular Biology, Chang Gung University, Taoyuan 33302, Taiwan. |
| authorships[3].institutions[0].id | https://openalex.org/I173093425 |
| authorships[3].institutions[0].ror | https://ror.org/00d80zx46 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I173093425 |
| authorships[3].institutions[0].country_code | TW |
| authorships[3].institutions[0].display_name | Chang Gung University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Hsun-Hao Yeh |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Biochemistry and Molecular Biology, Chang Gung University, Taoyuan 33302, Taiwan. |
| authorships[4].author.id | https://openalex.org/A5047227204 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Tsan-Lin Hu |
| authorships[4].countries | TW |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210148468 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Preclinical Drug Discovery Technology, Biomedical Technology and Devices Research Labs, Industrial Technology Research Institute, Hsinchu 31040, Taiwan. |
| authorships[4].institutions[0].id | https://openalex.org/I4210148468 |
| authorships[4].institutions[0].ror | https://ror.org/05szzwt63 |
| authorships[4].institutions[0].type | nonprofit |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210148468 |
| authorships[4].institutions[0].country_code | TW |
| authorships[4].institutions[0].display_name | Industrial Technology Research Institute |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Tsan-Lin Hu |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Preclinical Drug Discovery Technology, Biomedical Technology and Devices Research Labs, Industrial Technology Research Institute, Hsinchu 31040, Taiwan. |
| authorships[5].author.id | https://openalex.org/A5038534837 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-1877-2562 |
| authorships[5].author.display_name | Zong‐Keng Kuo |
| authorships[5].countries | TW |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210148468 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Preclinical Drug Discovery Technology, Biomedical Technology and Devices Research Labs, Industrial Technology Research Institute, Hsinchu 31040, Taiwan. |
| authorships[5].institutions[0].id | https://openalex.org/I4210148468 |
| authorships[5].institutions[0].ror | https://ror.org/05szzwt63 |
| authorships[5].institutions[0].type | nonprofit |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210148468 |
| authorships[5].institutions[0].country_code | TW |
| authorships[5].institutions[0].display_name | Industrial Technology Research Institute |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Zong-Keng Kuo |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Preclinical Drug Discovery Technology, Biomedical Technology and Devices Research Labs, Industrial Technology Research Institute, Hsinchu 31040, Taiwan. |
| authorships[6].author.id | https://openalex.org/A5101198556 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Yu-Chin Lin |
| authorships[6].countries | TW |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210148468 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Preclinical Drug Discovery Technology, Biomedical Technology and Devices Research Labs, Industrial Technology Research Institute, Hsinchu 31040, Taiwan. |
| authorships[6].institutions[0].id | https://openalex.org/I4210148468 |
| authorships[6].institutions[0].ror | https://ror.org/05szzwt63 |
| authorships[6].institutions[0].type | nonprofit |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210148468 |
| authorships[6].institutions[0].country_code | TW |
| authorships[6].institutions[0].display_name | Industrial Technology Research Institute |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Yu-Chin Lin |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Preclinical Drug Discovery Technology, Biomedical Technology and Devices Research Labs, Industrial Technology Research Institute, Hsinchu 31040, Taiwan. |
| authorships[7].author.id | https://openalex.org/A5001568481 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Mei-Ru Jhang |
| authorships[7].countries | TW |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210148468 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Preclinical Drug Discovery Technology, Biomedical Technology and Devices Research Labs, Industrial Technology Research Institute, Hsinchu 31040, Taiwan. |
| authorships[7].institutions[0].id | https://openalex.org/I4210148468 |
| authorships[7].institutions[0].ror | https://ror.org/05szzwt63 |
| authorships[7].institutions[0].type | nonprofit |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210148468 |
| authorships[7].institutions[0].country_code | TW |
| authorships[7].institutions[0].display_name | Industrial Technology Research Institute |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Mei-Ru Jhang |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Preclinical Drug Discovery Technology, Biomedical Technology and Devices Research Labs, Industrial Technology Research Institute, Hsinchu 31040, Taiwan. |
| authorships[8].author.id | https://openalex.org/A5018774287 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Chrong-Shiong Hwang |
| authorships[8].countries | TW |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210148468 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Preclinical Drug Discovery Technology, Biomedical Technology and Devices Research Labs, Industrial Technology Research Institute, Hsinchu 31040, Taiwan. |
| authorships[8].institutions[0].id | https://openalex.org/I4210148468 |
| authorships[8].institutions[0].ror | https://ror.org/05szzwt63 |
| authorships[8].institutions[0].type | nonprofit |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210148468 |
| authorships[8].institutions[0].country_code | TW |
| authorships[8].institutions[0].display_name | Industrial Technology Research Institute |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Chrong-Shiong Hwang |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Preclinical Drug Discovery Technology, Biomedical Technology and Devices Research Labs, Industrial Technology Research Institute, Hsinchu 31040, Taiwan. |
| authorships[9].author.id | https://openalex.org/A5024024448 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-4719-4143 |
| authorships[9].author.display_name | Hung‐Chih Hsu |
| authorships[9].countries | TW |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I173093425, https://openalex.org/I4210116208 |
| authorships[9].affiliations[0].raw_affiliation_string | Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan; College of Medicine, Chang Gung University, Taoyuan 33305, Taiwan. |
| authorships[9].institutions[0].id | https://openalex.org/I173093425 |
| authorships[9].institutions[0].ror | https://ror.org/00d80zx46 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I173093425 |
| authorships[9].institutions[0].country_code | TW |
| authorships[9].institutions[0].display_name | Chang Gung University |
| authorships[9].institutions[1].id | https://openalex.org/I4210116208 |
| authorships[9].institutions[1].ror | https://ror.org/02dnn6q67 |
| authorships[9].institutions[1].type | healthcare |
| authorships[9].institutions[1].lineage | https://openalex.org/I3020100970, https://openalex.org/I4210116208 |
| authorships[9].institutions[1].country_code | TW |
| authorships[9].institutions[1].display_name | Linkou Chang Gung Memorial Hospital |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Hung-Chih Hsu |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan; College of Medicine, Chang Gung University, Taoyuan 33305, Taiwan. |
| authorships[10].author.id | https://openalex.org/A5105975577 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-9903-5830 |
| authorships[10].author.display_name | Hsing‐Jien Kung |
| authorships[10].countries | TW |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I165441096, https://openalex.org/I47519274 |
| authorships[10].affiliations[0].raw_affiliation_string | Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan; Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan; Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan. |
| authorships[10].institutions[0].id | https://openalex.org/I165441096 |
| authorships[10].institutions[0].ror | https://ror.org/02r6fpx29 |
| authorships[10].institutions[0].type | nonprofit |
| authorships[10].institutions[0].lineage | https://openalex.org/I165441096 |
| authorships[10].institutions[0].country_code | TW |
| authorships[10].institutions[0].display_name | National Health Research Institutes |
| authorships[10].institutions[1].id | https://openalex.org/I47519274 |
| authorships[10].institutions[1].ror | https://ror.org/05031qk94 |
| authorships[10].institutions[1].type | education |
| authorships[10].institutions[1].lineage | https://openalex.org/I47519274 |
| authorships[10].institutions[1].country_code | TW |
| authorships[10].institutions[1].display_name | Taipei Medical University |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Hsing-Jien Kung |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan; Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan; Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan. |
| authorships[11].author.id | https://openalex.org/A5000687269 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-1413-817X |
| authorships[11].author.display_name | Ling‐Yu Wang |
| authorships[11].countries | TW |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I173093425, https://openalex.org/I4210116208 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Biochemistry and Molecular Biology, Chang Gung University, Taoyuan 33302, Taiwan; Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan. Electronic address: [email protected]. |
| authorships[11].institutions[0].id | https://openalex.org/I173093425 |
| authorships[11].institutions[0].ror | https://ror.org/00d80zx46 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I173093425 |
| authorships[11].institutions[0].country_code | TW |
| authorships[11].institutions[0].display_name | Chang Gung University |
| authorships[11].institutions[1].id | https://openalex.org/I4210116208 |
| authorships[11].institutions[1].ror | https://ror.org/02dnn6q67 |
| authorships[11].institutions[1].type | healthcare |
| authorships[11].institutions[1].lineage | https://openalex.org/I3020100970, https://openalex.org/I4210116208 |
| authorships[11].institutions[1].country_code | TW |
| authorships[11].institutions[1].display_name | Linkou Chang Gung Memorial Hospital |
| authorships[11].author_position | last |
| authorships[11].raw_author_name | Ling-Yu Wang |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Department of Biochemistry and Molecular Biology, Chang Gung University, Taoyuan 33302, Taiwan; Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan. Electronic address: [email protected]. |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1016/j.ebiom.2023.104500 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Targeting androgen receptor and the variants by an orally bioavailable Proteolysis Targeting Chimeras compound in castration resistant prostate cancer |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-07T23:20:04.922697 |
| primary_topic.id | https://openalex.org/T12534 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Protein Degradation and Inhibitors |
| related_works | https://openalex.org/W2561387856, https://openalex.org/W2905727460, https://openalex.org/W2050595427, https://openalex.org/W2767048879, https://openalex.org/W905145463, https://openalex.org/W2954455697, https://openalex.org/W2595758682, https://openalex.org/W4287355568, https://openalex.org/W2740124347, https://openalex.org/W2966112499 |
| cited_by_count | 30 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 9 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 15 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 6 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1016/j.ebiom.2023.104500 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2531685872 |
| best_oa_location.source.issn | 2352-3964 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2352-3964 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | EBioMedicine |
| best_oa_location.source.host_organization | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_name | Elsevier BV |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | eBioMedicine |
| best_oa_location.landing_page_url | https://doi.org/10.1016/j.ebiom.2023.104500 |
| primary_location.id | doi:10.1016/j.ebiom.2023.104500 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2531685872 |
| primary_location.source.issn | 2352-3964 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2352-3964 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | EBioMedicine |
| primary_location.source.host_organization | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_name | Elsevier BV |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | eBioMedicine |
| primary_location.landing_page_url | https://doi.org/10.1016/j.ebiom.2023.104500 |
| publication_date | 2023-03-06 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W3128646645, https://openalex.org/W2589238818, https://openalex.org/W2066845679, https://openalex.org/W1962442902, https://openalex.org/W2261870911, https://openalex.org/W2084637523, https://openalex.org/W2962518463, https://openalex.org/W3027418027, https://openalex.org/W3136835288, https://openalex.org/W2863183338, https://openalex.org/W1634543743, https://openalex.org/W2604800509, https://openalex.org/W2897146989, https://openalex.org/W2097226696, https://openalex.org/W2402183197, https://openalex.org/W1932786078, https://openalex.org/W2568836017, https://openalex.org/W2156923287, https://openalex.org/W2037700362, https://openalex.org/W2139711232, https://openalex.org/W1999343166, https://openalex.org/W1998691242, https://openalex.org/W2149131962, https://openalex.org/W2110841612, https://openalex.org/W2806280499, https://openalex.org/W1578291413, https://openalex.org/W2161112598, https://openalex.org/W2611741716, https://openalex.org/W2841328798, https://openalex.org/W3160556876, https://openalex.org/W6760152026, https://openalex.org/W3181847396, https://openalex.org/W2883077013, https://openalex.org/W3080167750, https://openalex.org/W2909034820, https://openalex.org/W2992546470, https://openalex.org/W2999280110, https://openalex.org/W3195255962, https://openalex.org/W3108430752, https://openalex.org/W1971209239, https://openalex.org/W2054598331, https://openalex.org/W6684211808, https://openalex.org/W2118238803, https://openalex.org/W3087584857, https://openalex.org/W3216437033, https://openalex.org/W2017919614, https://openalex.org/W2041708814, https://openalex.org/W2126959871, https://openalex.org/W1994344724, https://openalex.org/W1597238753, https://openalex.org/W2157709806, https://openalex.org/W2908693966, https://openalex.org/W2133946422, https://openalex.org/W3010407329, https://openalex.org/W2952205472, https://openalex.org/W2514715990, https://openalex.org/W2002111767, https://openalex.org/W2909353434, https://openalex.org/W2767251210, https://openalex.org/W3009753365, https://openalex.org/W3043624656, https://openalex.org/W2141569270, https://openalex.org/W2163839067, https://openalex.org/W2920736663 |
| referenced_works_count | 64 |
| abstract_inverted_index | |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 98 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 12 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5899999737739563 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.96364652 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |