Targeting apoptotic pathways for cancer therapy Article Swipe
Xiaobing Tian
,
Praveen R. Srinivasan
,
Vida Tajiknia
,
Ashley F. Sanchez Sevilla Uruchurtu
,
Attila A. Seyhan
,
Benedito A. Carneiro
,
Arielle De La Cruz
,
Maximilian Pinho-Schwermann
,
Andrew George
,
Shuai Zhao
,
Jillian Strandberg
,
Francesca Di Cristofano
,
Shengliang Zhang
,
Lanlan Zhou
,
Alexander G. Raufi
,
Arunasalam Navaraj
,
Yiqun Zhang
,
Nataliia Verovkina
,
Maryam Ghandali
,
Dinara Ryspayeva
,
Wafik S. El‐Deiry
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1172/jci179570
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1172/jci179570
Apoptosis is a form of programmed cell death that is mediated by intrinsic and extrinsic pathways. Dysregulation of and resistance to cell death are hallmarks of cancer. For over three decades, the development of therapies to promote treatment of cancer by inducing various cell death modalities, including apoptosis, has been a main goal of clinical oncology. Apoptosis pathways also interact with other signaling mechanisms, such as the p53 signaling pathway and the integrated stress response (ISR) pathway. In addition to agents directly targeting the intrinsic and extrinsic pathway components, anticancer drugs that target the p53 and ISR signaling pathways are actively being developed. In this Review, we discuss selected and promising anticancer therapies in various stages of development, including drug targets, mechanisms, and resistance to related treatments, focusing especially on B cell lymphoma 2 (BCL-2) inhibitors, TRAIL analogues, DR5 antibodies, and strategies that target p53, mutant p53, and the ISR.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1172/jci179570
- OA Status
- gold
- Cited By
- 74
- References
- 156
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4400620863Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1172/jci179570Digital Object Identifier
- Title
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Targeting apoptotic pathways for cancer therapyWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-07-14Full publication date if available
- Authors
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Xiaobing Tian, Praveen R. Srinivasan, Vida Tajiknia, Ashley F. Sanchez Sevilla Uruchurtu, Attila A. Seyhan, Benedito A. Carneiro, Arielle De La Cruz, Maximilian Pinho-Schwermann, Andrew George, Shuai Zhao, Jillian Strandberg, Francesca Di Cristofano, Shengliang Zhang, Lanlan Zhou, Alexander G. Raufi, Arunasalam Navaraj, Yiqun Zhang, Nataliia Verovkina, Maryam Ghandali, Dinara Ryspayeva, Wafik S. El‐DeiryList of authors in order
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https://doi.org/10.1172/jci179570Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1172/jci179570Direct OA link when available
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Apoptosis, Cancer, Cancer therapy, Cancer research, Medicine, Biology, Internal medicine, GeneticsTop concepts (fields/topics) attached by OpenAlex
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74Total citation count in OpenAlex
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2025: 68, 2024: 6Per-year citation counts (last 5 years)
- References (count)
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156Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| corresponding_author_ids | https://openalex.org/A5075201353, https://openalex.org/A5101452599 |
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| corresponding_institution_ids | https://openalex.org/I27804330, https://openalex.org/I4210110449, https://openalex.org/I4210151747 |
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