Targeting bone marrow adipocyte-driven fatty acid metabolism to overcome drug resistance in lung cancer bone metastasis Article Swipe
Jian Dong
,
Huaze Ding
,
Shuoer Wang
,
Shengzhe Ruan
,
Jianxin Ye
,
Peng Hu
,
Tong Meng
,
Wangjun Yan
,
Lei Zhou
,
Changping Wang
,
Dianwen Song
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1186/s12951-025-03792-2
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1186/s12951-025-03792-2
Lung cancer remains a leading cause of cancer-related mortality worldwide, with bone metastasis presenting a significant challenge due to its association with severe skeletal complications and therapy resistance. This study investigates the role of bone marrow adipocytes (BMAs) in modulating fatty acid metabolism within the bone metastatic niche of lung cancer. Utilizing single-cell sequencing and in vitro co-culture models, we identified critical interactions between BMAs and metastatic lung cancer cells that enhance fatty acid metabolism, promoting tumor survival and drug resistance. To target this metabolic axis, we screened a library of fatty acid synthesis inhibitors, and developed a nanoparticle system encapsulating kaempferol, and cisplatin, surface-modified with poly-aspartic acid for efficient bone targeting. The nanoparticles release their therapeutic payload in the acidic tumor microenvironment, disrupting fatty acid metabolism and overcoming chemoresistance. Our findings highlight the metabolic reprogramming driven by BMAs in bone metastasis and propose a novel therapeutic strategy to improve outcomes for patients with metastatic lung cancer.
Related Topics
Concepts
Fatty acid metabolism
Bone marrow
Bone metastasis
Cancer research
Metastasis
Medicine
Fatty acid
Lung cancer
Bone remodeling
Cancer
Drug resistance
Lung
Drug
Anabolism
Beta oxidation
Cancer cell
Metabolism
Bone cancer
Fatty acid synthesis
Carbohydrate metabolism
Catabolism
Chemistry
Pharmacology
In vivo
Tumor microenvironment
Lipid metabolism
Internal medicine
In vitro
Fatty acid synthase
Treatment of lung cancer
Combination therapy
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s12951-025-03792-2
- https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-025-03792-2
- OA Status
- gold
- References
- 41
- OpenAlex ID
- https://openalex.org/W7104515884
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W7104515884Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1186/s12951-025-03792-2Digital Object Identifier
- Title
-
Targeting bone marrow adipocyte-driven fatty acid metabolism to overcome drug resistance in lung cancer bone metastasisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-10Full publication date if available
- Authors
-
Jian Dong, Huaze Ding, Shuoer Wang, Shengzhe Ruan, Jianxin Ye, Peng Hu, Tong Meng, Wangjun Yan, Lei Zhou, Changping Wang, Dianwen SongList of authors in order
- Landing page
-
https://doi.org/10.1186/s12951-025-03792-2Publisher landing page
- PDF URL
-
https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-025-03792-2Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-025-03792-2Direct OA link when available
- Concepts
-
Fatty acid metabolism, Bone marrow, Bone metastasis, Cancer research, Metastasis, Medicine, Fatty acid, Lung cancer, Bone remodeling, Cancer, Drug resistance, Lung, Drug, Anabolism, Beta oxidation, Cancer cell, Metabolism, Bone cancer, Fatty acid synthesis, Carbohydrate metabolism, Catabolism, Chemistry, Pharmacology, In vivo, Tumor microenvironment, Lipid metabolism, Internal medicine, In vitro, Fatty acid synthase, Treatment of lung cancer, Combination therapyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
41Number of works referenced by this work
Full payload
| id | https://openalex.org/W7104515884 |
|---|---|
| doi | https://doi.org/10.1186/s12951-025-03792-2 |
| ids.doi | https://doi.org/10.1186/s12951-025-03792-2 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/41214690 |
| ids.openalex | https://openalex.org/W7104515884 |
| fwci | 0.0 |
| mesh[0].qualifier_ui | Q000473 |
| mesh[0].descriptor_ui | D008175 |
| mesh[0].is_major_topic | True |
| mesh[0].qualifier_name | pathology |
| mesh[0].descriptor_name | Lung Neoplasms |
| mesh[1].qualifier_ui | Q000378 |
| mesh[1].descriptor_ui | D008175 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | metabolism |
| mesh[1].descriptor_name | Lung Neoplasms |
| mesh[2].qualifier_ui | Q000188 |
| mesh[2].descriptor_ui | D008175 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | drug therapy |
| mesh[2].descriptor_name | Lung Neoplasms |
| mesh[3].qualifier_ui | Q000187 |
| mesh[3].descriptor_ui | D019008 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | drug effects |
| mesh[3].descriptor_name | Drug Resistance, Neoplasm |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D006801 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Humans |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D000818 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Animals |
| mesh[6].qualifier_ui | Q000556 |
| mesh[6].descriptor_ui | D001859 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | secondary |
| mesh[6].descriptor_name | Bone Neoplasms |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D001859 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | Bone Neoplasms |
| mesh[8].qualifier_ui | Q000188 |
| mesh[8].descriptor_ui | D001859 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | drug therapy |
| mesh[8].descriptor_name | Bone Neoplasms |
| mesh[9].qualifier_ui | Q000378 |
| mesh[9].descriptor_ui | D005227 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | metabolism |
| mesh[9].descriptor_name | Fatty Acids |
| mesh[10].qualifier_ui | Q000378 |
| mesh[10].descriptor_ui | D017667 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | metabolism |
| mesh[10].descriptor_name | Adipocytes |
| mesh[11].qualifier_ui | Q000187 |
| mesh[11].descriptor_ui | D017667 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | drug effects |
| mesh[11].descriptor_name | Adipocytes |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D051379 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Mice |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D045744 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Cell Line, Tumor |
| mesh[14].qualifier_ui | Q000737 |
| mesh[14].descriptor_ui | D053758 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | chemistry |
| mesh[14].descriptor_name | Nanoparticles |
| mesh[15].qualifier_ui | Q000494 |
| mesh[15].descriptor_ui | D000970 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | pharmacology |
| mesh[15].descriptor_name | Antineoplastic Agents |
| mesh[16].qualifier_ui | Q000494 |
| mesh[16].descriptor_ui | D002945 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | pharmacology |
| mesh[16].descriptor_name | Cisplatin |
| mesh[17].qualifier_ui | Q000187 |
| mesh[17].descriptor_ui | D059016 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | drug effects |
| mesh[17].descriptor_name | Tumor Microenvironment |
| mesh[18].qualifier_ui | Q000378 |
| mesh[18].descriptor_ui | D001853 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | metabolism |
| mesh[18].descriptor_name | Bone Marrow |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D018920 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Coculture Techniques |
| type | article |
| title | Targeting bone marrow adipocyte-driven fatty acid metabolism to overcome drug resistance in lung cancer bone metastasis |
| biblio.issue | 1 |
| biblio.volume | 23 |
| biblio.last_page | 709 |
| biblio.first_page | 709 |
| topics[0].id | https://openalex.org/T12465 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.8462386727333069 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1306 |
| topics[0].subfield.display_name | Cancer Research |
| topics[0].display_name | Cancer, Lipids, and Metabolism |
| topics[1].id | https://openalex.org/T10631 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.06848374754190445 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1306 |
| topics[1].subfield.display_name | Cancer Research |
| topics[1].display_name | Cancer, Hypoxia, and Metabolism |
| topics[2].id | https://openalex.org/T10336 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.015327947214245796 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2730 |
| topics[2].subfield.display_name | Oncology |
| topics[2].display_name | Cancer Cells and Metastasis |
| is_xpac | False |
| apc_list.value | 2190 |
| apc_list.currency | GBP |
| apc_list.value_usd | 2686 |
| apc_paid.value | 2190 |
| apc_paid.currency | GBP |
| apc_paid.value_usd | 2686 |
| concepts[0].id | https://openalex.org/C2776991927 |
| concepts[0].level | 3 |
| concepts[0].score | 0.610274076461792 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q14860867 |
| concepts[0].display_name | Fatty acid metabolism |
| concepts[1].id | https://openalex.org/C2780007613 |
| concepts[1].level | 2 |
| concepts[1].score | 0.5797781944274902 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q546523 |
| concepts[1].display_name | Bone marrow |
| concepts[2].id | https://openalex.org/C2777783956 |
| concepts[2].level | 4 |
| concepts[2].score | 0.5701934695243835 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q848085 |
| concepts[2].display_name | Bone metastasis |
| concepts[3].id | https://openalex.org/C502942594 |
| concepts[3].level | 1 |
| concepts[3].score | 0.5683755874633789 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[3].display_name | Cancer research |
| concepts[4].id | https://openalex.org/C2779013556 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5594587326049805 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q181876 |
| concepts[4].display_name | Metastasis |
| concepts[5].id | https://openalex.org/C71924100 |
| concepts[5].level | 0 |
| concepts[5].score | 0.5327736735343933 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[5].display_name | Medicine |
| concepts[6].id | https://openalex.org/C543025807 |
| concepts[6].level | 2 |
| concepts[6].score | 0.45586493611335754 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q61476 |
| concepts[6].display_name | Fatty acid |
| concepts[7].id | https://openalex.org/C2776256026 |
| concepts[7].level | 2 |
| concepts[7].score | 0.4244832396507263 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q47912 |
| concepts[7].display_name | Lung cancer |
| concepts[8].id | https://openalex.org/C170033053 |
| concepts[8].level | 2 |
| concepts[8].score | 0.4070756435394287 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q952019 |
| concepts[8].display_name | Bone remodeling |
| concepts[9].id | https://openalex.org/C121608353 |
| concepts[9].level | 2 |
| concepts[9].score | 0.3727096617221832 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[9].display_name | Cancer |
| concepts[10].id | https://openalex.org/C114851261 |
| concepts[10].level | 2 |
| concepts[10].score | 0.35989561676979065 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q12147416 |
| concepts[10].display_name | Drug resistance |
| concepts[11].id | https://openalex.org/C2777714996 |
| concepts[11].level | 2 |
| concepts[11].score | 0.3544115722179413 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7886 |
| concepts[11].display_name | Lung |
| concepts[12].id | https://openalex.org/C2780035454 |
| concepts[12].level | 2 |
| concepts[12].score | 0.3380005359649658 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q8386 |
| concepts[12].display_name | Drug |
| concepts[13].id | https://openalex.org/C1008401 |
| concepts[13].level | 2 |
| concepts[13].score | 0.33286118507385254 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q184681 |
| concepts[13].display_name | Anabolism |
| concepts[14].id | https://openalex.org/C82714985 |
| concepts[14].level | 3 |
| concepts[14].score | 0.3309989869594574 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q306213 |
| concepts[14].display_name | Beta oxidation |
| concepts[15].id | https://openalex.org/C96232424 |
| concepts[15].level | 3 |
| concepts[15].score | 0.3252551555633545 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q4118072 |
| concepts[15].display_name | Cancer cell |
| concepts[16].id | https://openalex.org/C62231903 |
| concepts[16].level | 2 |
| concepts[16].score | 0.32404428720474243 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q1057 |
| concepts[16].display_name | Metabolism |
| concepts[17].id | https://openalex.org/C2776035513 |
| concepts[17].level | 3 |
| concepts[17].score | 0.310079425573349 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q1328805 |
| concepts[17].display_name | Bone cancer |
| concepts[18].id | https://openalex.org/C2776941171 |
| concepts[18].level | 3 |
| concepts[18].score | 0.3050273060798645 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q900209 |
| concepts[18].display_name | Fatty acid synthesis |
| concepts[19].id | https://openalex.org/C17093226 |
| concepts[19].level | 2 |
| concepts[19].score | 0.30272185802459717 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q2734081 |
| concepts[19].display_name | Carbohydrate metabolism |
| concepts[20].id | https://openalex.org/C96942376 |
| concepts[20].level | 3 |
| concepts[20].score | 0.29283303022384644 |
| concepts[20].wikidata | https://www.wikidata.org/wiki/Q21130714 |
| concepts[20].display_name | Catabolism |
| concepts[21].id | https://openalex.org/C185592680 |
| concepts[21].level | 0 |
| concepts[21].score | 0.286181777715683 |
| concepts[21].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[21].display_name | Chemistry |
| concepts[22].id | https://openalex.org/C98274493 |
| concepts[22].level | 1 |
| concepts[22].score | 0.2833158075809479 |
| concepts[22].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[22].display_name | Pharmacology |
| concepts[23].id | https://openalex.org/C207001950 |
| concepts[23].level | 2 |
| concepts[23].score | 0.26470932364463806 |
| concepts[23].wikidata | https://www.wikidata.org/wiki/Q141124 |
| concepts[23].display_name | In vivo |
| concepts[24].id | https://openalex.org/C2776107976 |
| concepts[24].level | 3 |
| concepts[24].score | 0.26335737109184265 |
| concepts[24].wikidata | https://www.wikidata.org/wiki/Q1786433 |
| concepts[24].display_name | Tumor microenvironment |
| concepts[25].id | https://openalex.org/C4733338 |
| concepts[25].level | 2 |
| concepts[25].score | 0.2632661759853363 |
| concepts[25].wikidata | https://www.wikidata.org/wiki/Q2792936 |
| concepts[25].display_name | Lipid metabolism |
| concepts[26].id | https://openalex.org/C126322002 |
| concepts[26].level | 1 |
| concepts[26].score | 0.25479578971862793 |
| concepts[26].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[26].display_name | Internal medicine |
| concepts[27].id | https://openalex.org/C202751555 |
| concepts[27].level | 2 |
| concepts[27].score | 0.25365152955055237 |
| concepts[27].wikidata | https://www.wikidata.org/wiki/Q221681 |
| concepts[27].display_name | In vitro |
| concepts[28].id | https://openalex.org/C48289651 |
| concepts[28].level | 3 |
| concepts[28].score | 0.25244781374931335 |
| concepts[28].wikidata | https://www.wikidata.org/wiki/Q106916817 |
| concepts[28].display_name | Fatty acid synthase |
| concepts[29].id | https://openalex.org/C2778807442 |
| concepts[29].level | 3 |
| concepts[29].score | 0.25084081292152405 |
| concepts[29].wikidata | https://www.wikidata.org/wiki/Q6152005 |
| concepts[29].display_name | Treatment of lung cancer |
| concepts[30].id | https://openalex.org/C2776999253 |
| concepts[30].level | 2 |
| concepts[30].score | 0.2506099343299866 |
| concepts[30].wikidata | https://www.wikidata.org/wiki/Q1304270 |
| concepts[30].display_name | Combination therapy |
| keywords[0].id | https://openalex.org/keywords/fatty-acid-metabolism |
| keywords[0].score | 0.610274076461792 |
| keywords[0].display_name | Fatty acid metabolism |
| keywords[1].id | https://openalex.org/keywords/bone-marrow |
| keywords[1].score | 0.5797781944274902 |
| keywords[1].display_name | Bone marrow |
| keywords[2].id | https://openalex.org/keywords/bone-metastasis |
| keywords[2].score | 0.5701934695243835 |
| keywords[2].display_name | Bone metastasis |
| keywords[3].id | https://openalex.org/keywords/metastasis |
| keywords[3].score | 0.5594587326049805 |
| keywords[3].display_name | Metastasis |
| keywords[4].id | https://openalex.org/keywords/fatty-acid |
| keywords[4].score | 0.45586493611335754 |
| keywords[4].display_name | Fatty acid |
| keywords[5].id | https://openalex.org/keywords/lung-cancer |
| keywords[5].score | 0.4244832396507263 |
| keywords[5].display_name | Lung cancer |
| keywords[6].id | https://openalex.org/keywords/bone-remodeling |
| keywords[6].score | 0.4070756435394287 |
| keywords[6].display_name | Bone remodeling |
| keywords[7].id | https://openalex.org/keywords/cancer |
| keywords[7].score | 0.3727096617221832 |
| keywords[7].display_name | Cancer |
| keywords[8].id | https://openalex.org/keywords/drug-resistance |
| keywords[8].score | 0.35989561676979065 |
| keywords[8].display_name | Drug resistance |
| language | en |
| locations[0].id | doi:10.1186/s12951-025-03792-2 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S41231013 |
| locations[0].source.issn | 1477-3155 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1477-3155 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Journal of Nanobiotechnology |
| locations[0].source.host_organization | https://openalex.org/P4310320256 |
| locations[0].source.host_organization_name | BioMed Central |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320256 |
| locations[0].license | cc-by-nc-nd |
| locations[0].pdf_url | https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-025-03792-2 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Nanobiotechnology |
| locations[0].landing_page_url | https://doi.org/10.1186/s12951-025-03792-2 |
| locations[1].id | pmid:41214690 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Journal of nanobiotechnology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/41214690 |
| locations[2].id | pmh:oai:doaj.org/article:c2563f85f917404cbccd465d734c0e95 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].source.host_organization_lineage | |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Journal of Nanobiotechnology, Vol 23, Iss 1, Pp 1-19 (2025) |
| locations[2].landing_page_url | https://doaj.org/article/c2563f85f917404cbccd465d734c0e95 |
| locations[3].id | pmh:oai:europepmc.org:11412578 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400806 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Europe PMC (PubMed Central) |
| locations[3].source.host_organization | https://openalex.org/I1303153112 |
| locations[3].source.host_organization_name | European Bioinformatics Institute |
| locations[3].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12604269 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A2098119416 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-5660-0863 |
| authorships[0].author.display_name | Jian Dong |
| authorships[0].countries | CN |
| authorships[0].institutions[0].id | https://openalex.org/I133868755 |
| authorships[0].institutions[0].ror | https://ror.org/https://ror.org/01zntxs11 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I133868755, https://openalex.org/I24943067 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Shanghai Medical College of Fudan University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Jian Dong |
| authorships[0].is_corresponding | True |
| authorships[1].author.id | https://openalex.org/A4224123993 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-3720-0623 |
| authorships[1].author.display_name | Huaze Ding |
| authorships[1].countries | CN |
| authorships[1].institutions[0].id | https://openalex.org/I4210135742 |
| authorships[1].institutions[0].ror | https://ror.org/https://ror.org/04a46mh28 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210135742 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Shanghai First People's Hospital |
| authorships[1].institutions[1].id | https://openalex.org/I183067930 |
| authorships[1].institutions[1].ror | https://ror.org/https://ror.org/0220qvk04 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I183067930 |
| authorships[1].institutions[1].country_code | CN |
| authorships[1].institutions[1].display_name | Shanghai Jiao Tong University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Huaze Ding |
| authorships[1].is_corresponding | False |
| authorships[2].author.id | https://openalex.org/A2896961212 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-4315-1776 |
| authorships[2].author.display_name | Shuoer Wang |
| authorships[2].countries | CN |
| authorships[2].institutions[0].id | https://openalex.org/I183067930 |
| authorships[2].institutions[0].ror | https://ror.org/https://ror.org/0220qvk04 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I183067930 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Shanghai Jiao Tong University |
| authorships[2].institutions[1].id | https://openalex.org/I4210093194 |
| authorships[2].institutions[1].ror | https://ror.org/https://ror.org/00my25942 |
| authorships[2].institutions[1].type | healthcare |
| authorships[2].institutions[1].lineage | https://openalex.org/I4210093194 |
| authorships[2].institutions[1].country_code | CN |
| authorships[2].institutions[1].display_name | Fudan University Shanghai Cancer Center |
| authorships[2].institutions[2].id | https://openalex.org/I4210135742 |
| authorships[2].institutions[2].ror | https://ror.org/https://ror.org/04a46mh28 |
| authorships[2].institutions[2].type | healthcare |
| authorships[2].institutions[2].lineage | https://openalex.org/I4210135742 |
| authorships[2].institutions[2].country_code | CN |
| authorships[2].institutions[2].display_name | Shanghai First People's Hospital |
| authorships[2].institutions[3].id | https://openalex.org/I133868755 |
| authorships[2].institutions[3].ror | https://ror.org/https://ror.org/01zntxs11 |
| authorships[2].institutions[3].type | education |
| authorships[2].institutions[3].lineage | https://openalex.org/I133868755, https://openalex.org/I24943067 |
| authorships[2].institutions[3].country_code | CN |
| authorships[2].institutions[3].display_name | Shanghai Medical College of Fudan University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Shuoer Wang |
| authorships[2].is_corresponding | False |
| authorships[3].author.id | https://openalex.org/A3026007162 |
| authorships[3].author.orcid | https://orcid.org/0009-0008-3404-6505 |
| authorships[3].author.display_name | Shengzhe Ruan |
| authorships[3].countries | CN |
| authorships[3].institutions[0].id | https://openalex.org/I4210135742 |
| authorships[3].institutions[0].ror | https://ror.org/https://ror.org/04a46mh28 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210135742 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Shanghai First People's Hospital |
| authorships[3].institutions[1].id | https://openalex.org/I183067930 |
| authorships[3].institutions[1].ror | https://ror.org/https://ror.org/0220qvk04 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I183067930 |
| authorships[3].institutions[1].country_code | CN |
| authorships[3].institutions[1].display_name | Shanghai Jiao Tong University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Shengzhe Ruan |
| authorships[3].is_corresponding | False |
| authorships[4].author.id | https://openalex.org/A2099224872 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-5401-2280 |
| authorships[4].author.display_name | Jianxin Ye |
| authorships[4].countries | CN |
| authorships[4].institutions[0].id | https://openalex.org/I4210135742 |
| authorships[4].institutions[0].ror | https://ror.org/https://ror.org/04a46mh28 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210135742 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Shanghai First People's Hospital |
| authorships[4].institutions[1].id | https://openalex.org/I183067930 |
| authorships[4].institutions[1].ror | https://ror.org/https://ror.org/0220qvk04 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I183067930 |
| authorships[4].institutions[1].country_code | CN |
| authorships[4].institutions[1].display_name | Shanghai Jiao Tong University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Jianxin Ye |
| authorships[4].is_corresponding | False |
| authorships[5].author.id | https://openalex.org/A2058312879 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-5098-3920 |
| authorships[5].author.display_name | Peng Hu |
| authorships[5].countries | CN |
| authorships[5].institutions[0].id | https://openalex.org/I4210135742 |
| authorships[5].institutions[0].ror | https://ror.org/https://ror.org/04a46mh28 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210135742 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | Shanghai First People's Hospital |
| authorships[5].institutions[1].id | https://openalex.org/I183067930 |
| authorships[5].institutions[1].ror | https://ror.org/https://ror.org/0220qvk04 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I183067930 |
| authorships[5].institutions[1].country_code | CN |
| authorships[5].institutions[1].display_name | Shanghai Jiao Tong University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Peng Hu |
| authorships[5].is_corresponding | False |
| authorships[6].author.id | https://openalex.org/A2101458962 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-6403-1357 |
| authorships[6].author.display_name | Tong Meng |
| authorships[6].countries | CN |
| authorships[6].institutions[0].id | https://openalex.org/I4210135742 |
| authorships[6].institutions[0].ror | https://ror.org/https://ror.org/04a46mh28 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210135742 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | Shanghai First People's Hospital |
| authorships[6].institutions[1].id | https://openalex.org/I133868755 |
| authorships[6].institutions[1].ror | https://ror.org/https://ror.org/01zntxs11 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I133868755, https://openalex.org/I24943067 |
| authorships[6].institutions[1].country_code | CN |
| authorships[6].institutions[1].display_name | Shanghai Medical College of Fudan University |
| authorships[6].institutions[2].id | https://openalex.org/I183067930 |
| authorships[6].institutions[2].ror | https://ror.org/https://ror.org/0220qvk04 |
| authorships[6].institutions[2].type | education |
| authorships[6].institutions[2].lineage | https://openalex.org/I183067930 |
| authorships[6].institutions[2].country_code | CN |
| authorships[6].institutions[2].display_name | Shanghai Jiao Tong University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Tong Meng |
| authorships[6].is_corresponding | False |
| authorships[7].author.id | https://openalex.org/A2137284944 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-5023-8146 |
| authorships[7].author.display_name | Wangjun Yan |
| authorships[7].countries | CN |
| authorships[7].institutions[0].id | https://openalex.org/I4210093194 |
| authorships[7].institutions[0].ror | https://ror.org/https://ror.org/00my25942 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210093194 |
| authorships[7].institutions[0].country_code | CN |
| authorships[7].institutions[0].display_name | Fudan University Shanghai Cancer Center |
| authorships[7].institutions[1].id | https://openalex.org/I133868755 |
| authorships[7].institutions[1].ror | https://ror.org/https://ror.org/01zntxs11 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I133868755, https://openalex.org/I24943067 |
| authorships[7].institutions[1].country_code | CN |
| authorships[7].institutions[1].display_name | Shanghai Medical College of Fudan University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Wangjun Yan |
| authorships[7].is_corresponding | False |
| authorships[8].author.id | https://openalex.org/A2099005581 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-5071-5571 |
| authorships[8].author.display_name | Lei Zhou |
| authorships[8].countries | CN |
| authorships[8].institutions[0].id | https://openalex.org/I133868755 |
| authorships[8].institutions[0].ror | https://ror.org/https://ror.org/01zntxs11 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I133868755, https://openalex.org/I24943067 |
| authorships[8].institutions[0].country_code | CN |
| authorships[8].institutions[0].display_name | Shanghai Medical College of Fudan University |
| authorships[8].institutions[1].id | https://openalex.org/I183067930 |
| authorships[8].institutions[1].ror | https://ror.org/https://ror.org/0220qvk04 |
| authorships[8].institutions[1].type | education |
| authorships[8].institutions[1].lineage | https://openalex.org/I183067930 |
| authorships[8].institutions[1].country_code | CN |
| authorships[8].institutions[1].display_name | Shanghai Jiao Tong University |
| authorships[8].institutions[2].id | https://openalex.org/I4210135742 |
| authorships[8].institutions[2].ror | https://ror.org/https://ror.org/04a46mh28 |
| authorships[8].institutions[2].type | healthcare |
| authorships[8].institutions[2].lineage | https://openalex.org/I4210135742 |
| authorships[8].institutions[2].country_code | CN |
| authorships[8].institutions[2].display_name | Shanghai First People's Hospital |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Lei Zhou |
| authorships[8].is_corresponding | False |
| authorships[9].author.id | https://openalex.org/A2103819154 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-9330-2379 |
| authorships[9].author.display_name | Changping Wang |
| authorships[9].countries | CN |
| authorships[9].institutions[0].id | https://openalex.org/I133868755 |
| authorships[9].institutions[0].ror | https://ror.org/https://ror.org/01zntxs11 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I133868755, https://openalex.org/I24943067 |
| authorships[9].institutions[0].country_code | CN |
| authorships[9].institutions[0].display_name | Shanghai Medical College of Fudan University |
| authorships[9].institutions[1].id | https://openalex.org/I4210107879 |
| authorships[9].institutions[1].ror | https://ror.org/https://ror.org/01r8rcr36 |
| authorships[9].institutions[1].type | healthcare |
| authorships[9].institutions[1].lineage | https://openalex.org/I4210107879 |
| authorships[9].institutions[1].country_code | CN |
| authorships[9].institutions[1].display_name | Tongren Hospital |
| authorships[9].institutions[2].id | https://openalex.org/I183067930 |
| authorships[9].institutions[2].ror | https://ror.org/https://ror.org/0220qvk04 |
| authorships[9].institutions[2].type | education |
| authorships[9].institutions[2].lineage | https://openalex.org/I183067930 |
| authorships[9].institutions[2].country_code | CN |
| authorships[9].institutions[2].display_name | Shanghai Jiao Tong University |
| authorships[9].institutions[3].id | https://openalex.org/I4210135742 |
| authorships[9].institutions[3].ror | https://ror.org/https://ror.org/04a46mh28 |
| authorships[9].institutions[3].type | healthcare |
| authorships[9].institutions[3].lineage | https://openalex.org/I4210135742 |
| authorships[9].institutions[3].country_code | CN |
| authorships[9].institutions[3].display_name | Shanghai First People's Hospital |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Changping Wang |
| authorships[9].is_corresponding | False |
| authorships[10].author.id | https://openalex.org/A2120917899 |
| authorships[10].author.orcid | https://orcid.org/0000-0001-6161-2260 |
| authorships[10].author.display_name | Dianwen Song |
| authorships[10].countries | CN |
| authorships[10].institutions[0].id | https://openalex.org/I183067930 |
| authorships[10].institutions[0].ror | https://ror.org/https://ror.org/0220qvk04 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I183067930 |
| authorships[10].institutions[0].country_code | CN |
| authorships[10].institutions[0].display_name | Shanghai Jiao Tong University |
| authorships[10].institutions[1].id | https://openalex.org/I4210107879 |
| authorships[10].institutions[1].ror | https://ror.org/https://ror.org/01r8rcr36 |
| authorships[10].institutions[1].type | healthcare |
| authorships[10].institutions[1].lineage | https://openalex.org/I4210107879 |
| authorships[10].institutions[1].country_code | CN |
| authorships[10].institutions[1].display_name | Tongren Hospital |
| authorships[10].institutions[2].id | https://openalex.org/I4210135742 |
| authorships[10].institutions[2].ror | https://ror.org/https://ror.org/04a46mh28 |
| authorships[10].institutions[2].type | healthcare |
| authorships[10].institutions[2].lineage | https://openalex.org/I4210135742 |
| authorships[10].institutions[2].country_code | CN |
| authorships[10].institutions[2].display_name | Shanghai First People's Hospital |
| authorships[10].institutions[3].id | https://openalex.org/I133868755 |
| authorships[10].institutions[3].ror | https://ror.org/https://ror.org/01zntxs11 |
| authorships[10].institutions[3].type | education |
| authorships[10].institutions[3].lineage | https://openalex.org/I133868755, https://openalex.org/I24943067 |
| authorships[10].institutions[3].country_code | CN |
| authorships[10].institutions[3].display_name | Shanghai Medical College of Fudan University |
| authorships[10].author_position | last |
| authorships[10].raw_author_name | Dianwen Song |
| authorships[10].is_corresponding | False |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-025-03792-2 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-11-10T00:00:00 |
| display_name | Targeting bone marrow adipocyte-driven fatty acid metabolism to overcome drug resistance in lung cancer bone metastasis |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-11T23:18:09.558992 |
| primary_topic.id | https://openalex.org/T12465 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.8462386727333069 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1306 |
| primary_topic.subfield.display_name | Cancer Research |
| primary_topic.display_name | Cancer, Lipids, and Metabolism |
| cited_by_count | 0 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1186/s12951-025-03792-2 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S41231013 |
| best_oa_location.source.issn | 1477-3155 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1477-3155 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Journal of Nanobiotechnology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320256 |
| best_oa_location.source.host_organization_name | BioMed Central |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320256 |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-025-03792-2 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Journal of Nanobiotechnology |
| best_oa_location.landing_page_url | https://doi.org/10.1186/s12951-025-03792-2 |
| primary_location.id | doi:10.1186/s12951-025-03792-2 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S41231013 |
| primary_location.source.issn | 1477-3155 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1477-3155 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Journal of Nanobiotechnology |
| primary_location.source.host_organization | https://openalex.org/P4310320256 |
| primary_location.source.host_organization_name | BioMed Central |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320256 |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-025-03792-2 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Nanobiotechnology |
| primary_location.landing_page_url | https://doi.org/10.1186/s12951-025-03792-2 |
| publication_date | 2025-11-10 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2508069933, https://openalex.org/W3118657348, https://openalex.org/W2903376111, https://openalex.org/W2012295597, https://openalex.org/W3045786341, https://openalex.org/W4283011229, https://openalex.org/W4411874266, https://openalex.org/W2071661010, https://openalex.org/W4366498247, https://openalex.org/W4409117025, https://openalex.org/W2960816547, https://openalex.org/W4399990210, https://openalex.org/W2938629106, https://openalex.org/W3044908880, https://openalex.org/W2992324722, https://openalex.org/W2984955289, https://openalex.org/W2902377196, https://openalex.org/W3195953296, https://openalex.org/W4385221592, https://openalex.org/W3217589610, https://openalex.org/W4385667538, https://openalex.org/W4389868590, https://openalex.org/W2396599501, https://openalex.org/W3193972753, https://openalex.org/W4383336642, https://openalex.org/W2897926526, https://openalex.org/W3192477828, https://openalex.org/W4392468516, https://openalex.org/W4384407989, https://openalex.org/W2610146492, https://openalex.org/W2534024300, https://openalex.org/W2034590888, https://openalex.org/W2127825296, https://openalex.org/W2613784864, https://openalex.org/W1992696749, https://openalex.org/W2143845923, https://openalex.org/W4403082018, https://openalex.org/W2161474008, https://openalex.org/W2152675473, https://openalex.org/W4317254683, https://openalex.org/W4379376877 |
| referenced_works_count | 41 |
| abstract_inverted_index.a | 3, 14, 88, 97, 144 |
| abstract_inverted_index.To | 81 |
| abstract_inverted_index.by | 137 |
| abstract_inverted_index.in | 38, 55, 118, 139 |
| abstract_inverted_index.of | 6, 33, 48, 90 |
| abstract_inverted_index.to | 18, 148 |
| abstract_inverted_index.we | 59, 86 |
| abstract_inverted_index.Our | 130 |
| abstract_inverted_index.The | 112 |
| abstract_inverted_index.and | 25, 54, 65, 78, 95, 102, 127, 142 |
| abstract_inverted_index.due | 17 |
| abstract_inverted_index.for | 108, 151 |
| abstract_inverted_index.its | 19 |
| abstract_inverted_index.the | 31, 44, 119, 133 |
| abstract_inverted_index.BMAs | 64, 138 |
| abstract_inverted_index.Lung | 0 |
| abstract_inverted_index.This | 28 |
| abstract_inverted_index.acid | 41, 73, 92, 107, 125 |
| abstract_inverted_index.bone | 11, 34, 45, 110, 140 |
| abstract_inverted_index.drug | 79 |
| abstract_inverted_index.lung | 49, 67, 155 |
| abstract_inverted_index.role | 32 |
| abstract_inverted_index.that | 70 |
| abstract_inverted_index.this | 83 |
| abstract_inverted_index.with | 10, 21, 105, 153 |
| abstract_inverted_index.axis, | 85 |
| abstract_inverted_index.cause | 5 |
| abstract_inverted_index.cells | 69 |
| abstract_inverted_index.fatty | 40, 72, 91, 124 |
| abstract_inverted_index.niche | 47 |
| abstract_inverted_index.novel | 145 |
| abstract_inverted_index.study | 29 |
| abstract_inverted_index.their | 115 |
| abstract_inverted_index.tumor | 76, 121 |
| abstract_inverted_index.vitro | 56 |
| abstract_inverted_index.(BMAs) | 37 |
| abstract_inverted_index.acidic | 120 |
| abstract_inverted_index.cancer | 1, 68 |
| abstract_inverted_index.driven | 136 |
| abstract_inverted_index.marrow | 35 |
| abstract_inverted_index.severe | 22 |
| abstract_inverted_index.system | 99 |
| abstract_inverted_index.target | 82 |
| abstract_inverted_index.within | 43 |
| abstract_inverted_index.between | 63 |
| abstract_inverted_index.cancer. | 50, 156 |
| abstract_inverted_index.enhance | 71 |
| abstract_inverted_index.improve | 149 |
| abstract_inverted_index.leading | 4 |
| abstract_inverted_index.library | 89 |
| abstract_inverted_index.models, | 58 |
| abstract_inverted_index.payload | 117 |
| abstract_inverted_index.propose | 143 |
| abstract_inverted_index.release | 114 |
| abstract_inverted_index.remains | 2 |
| abstract_inverted_index.therapy | 26 |
| abstract_inverted_index.critical | 61 |
| abstract_inverted_index.findings | 131 |
| abstract_inverted_index.outcomes | 150 |
| abstract_inverted_index.patients | 152 |
| abstract_inverted_index.screened | 87 |
| abstract_inverted_index.skeletal | 23 |
| abstract_inverted_index.strategy | 147 |
| abstract_inverted_index.survival | 77 |
| abstract_inverted_index.Utilizing | 51 |
| abstract_inverted_index.challenge | 16 |
| abstract_inverted_index.developed | 96 |
| abstract_inverted_index.efficient | 109 |
| abstract_inverted_index.highlight | 132 |
| abstract_inverted_index.metabolic | 84, 134 |
| abstract_inverted_index.mortality | 8 |
| abstract_inverted_index.promoting | 75 |
| abstract_inverted_index.synthesis | 93 |
| abstract_inverted_index.adipocytes | 36 |
| abstract_inverted_index.cisplatin, | 103 |
| abstract_inverted_index.co-culture | 57 |
| abstract_inverted_index.disrupting | 123 |
| abstract_inverted_index.identified | 60 |
| abstract_inverted_index.metabolism | 42, 126 |
| abstract_inverted_index.metastasis | 12, 141 |
| abstract_inverted_index.metastatic | 46, 66, 154 |
| abstract_inverted_index.modulating | 39 |
| abstract_inverted_index.overcoming | 128 |
| abstract_inverted_index.presenting | 13 |
| abstract_inverted_index.sequencing | 53 |
| abstract_inverted_index.targeting. | 111 |
| abstract_inverted_index.worldwide, | 9 |
| abstract_inverted_index.association | 20 |
| abstract_inverted_index.inhibitors, | 94 |
| abstract_inverted_index.kaempferol, | 101 |
| abstract_inverted_index.metabolism, | 74 |
| abstract_inverted_index.resistance. | 27, 80 |
| abstract_inverted_index.significant | 15 |
| abstract_inverted_index.single-cell | 52 |
| abstract_inverted_index.therapeutic | 116, 146 |
| abstract_inverted_index.interactions | 62 |
| abstract_inverted_index.investigates | 30 |
| abstract_inverted_index.nanoparticle | 98 |
| abstract_inverted_index.complications | 24 |
| abstract_inverted_index.encapsulating | 100 |
| abstract_inverted_index.nanoparticles | 113 |
| abstract_inverted_index.poly-aspartic | 106 |
| abstract_inverted_index.reprogramming | 135 |
| abstract_inverted_index.cancer-related | 7 |
| abstract_inverted_index.chemoresistance. | 129 |
| abstract_inverted_index.surface-modified | 104 |
| abstract_inverted_index.microenvironment, | 122 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| citation_normalized_percentile.value | 0.75961502 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |