Targeting Leukemia Stem Cells: Which Pathways Drive Self-Renewal Activity in T-Cell Acute Lymphoblastic Leukemia? Article Swipe

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Miriam Belmonte , Catherine Hoofd , Andrew P. Weng , Vincenzo Giambra ·

YOU? · · 2016 · Open Access · · DOI: https://doi.org/10.3747/co.23.2806

T-Cell acute lymphoblastic leukemia (T-ALL) is a malignancy of white blood cells, characterized by an uncontrolled accumulation of T-cell progenitors. During leukemic progression, immature T cells grow abnormally and crowd into the bone marrow, preventing it from making normal blood cells and spilling out into the bloodstream. Recent studies suggest that only discrete cell populations that possess the ability to recreate the entire tumour might be responsible for the initiation and propagation of T-ALL. Those unique cells are commonly called “cancer stem cells” or, in the case of hematopoietic malignancies, “leukemia stem cells” (LSCs). Like normal hematopoietic stem cells, LSCs are thought to be capable of self-renewal, during which, by asymmetrical division, they give rise to an identical copy of themselves as well as to a daughter cell that is no longer capable of self-renewal activity and represents a more “differentiated” progeny. Here, we review the main pathways of self-renewal activity in LSCs, focusing on their involvement in the maintenance and development of T-ALL. New stem cell–directed therapies and LSC-targeted agents are also discussed.

Related Topics

Acute Lymphoblastic Leukemia

Cell (Biology)

Cell Biology

Concepts

Stem cell Haematopoiesis Leukemia Progenitor cell Cancer research Bone marrow Medicine Cancer stem cell Immunology Cell division Biology Lymphoblastic Leukemia Stem cell theory of aging Cell Cell biology Stem cell factor Genetics

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Type: review
Language: en
Landing Page: https://doi.org/10.3747/co.23.2806
PDF: https://www.mdpi.com/1718-7729/23/1/2806/pdf?version=1609334254
OA Status: gold
Cited By: 22
References: 87
Related Works: 10
OpenAlex ID: https://openalex.org/W2283761750

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OpenAlex ID: https://openalex.org/W2283761750

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DOI: https://doi.org/10.3747/co.23.2806

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Title: Targeting Leukemia Stem Cells: Which Pathways Drive Self-Renewal Activity in T-Cell Acute Lymphoblastic Leukemia?

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Type: review

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Language: en

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Publication year: 2016

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Publication date: 2016-02-01

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Authors: Miriam Belmonte, Catherine Hoofd, Andrew P. Weng, Vincenzo Giambra

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Landing page: https://doi.org/10.3747/co.23.2806

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PDF URL: https://www.mdpi.com/1718-7729/23/1/2806/pdf?version=1609334254

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Concepts: Stem cell, Haematopoiesis, Leukemia, Progenitor cell, Cancer research, Bone marrow, Medicine, Cancer stem cell, Immunology, Cell division, Biology, Lymphoblastic Leukemia, Stem cell theory of aging, Cell, Cell biology, Stem cell factor, Genetics

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Cited by: 22

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Citations by year (recent): 2025: 2, 2023: 1, 2021: 4, 2020: 2, 2019: 4

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