Targeting MT‐tsRNA IDDMT with Nanoparticles to Annulus Fibrosus: A Novel Therapeutic Approach for Intervertebral Disc Degeneration Article Swipe
Changxiong Cai
,
Yameng Wang
,
Zhiwen Wu
,
Shengqin Li
,
Jiangminghao Zhao
,
Tao Li
,
Xigao Cheng
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/adhm.202502795
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/adhm.202502795
Annulus fibrosus (AF) injury is a significant cause of NP protrusion and intervertebral disc degeneration (IDD). Currently, the molecular mechanisms of IDD remain unclear, and there is a lack of methods for early diagnosis and targeted drug delivery through the circulatory system. This study focuses on the mitochondria‐derived tsRNA, IDDMT (IDD‐related mitochondrial‐derived tsRNA, mt‐TRF3‐24‐AspGTC), which is significantly upregulated in degenerated AF tissues of intervertebral discs. Mechanistically, IDDMT overexpression interacts with IMPDH2, activating the NF‐κB signaling pathway and leading to mitochondrial dysfunction, ROS production, and apoptosis in AF cells. To address this issue, a nanocarrier system, UCNP (NaGdF 4 @NaErF 4 @NaLuF 4 @MSN@ZIF‐8@IN‐IDDMT@Suc‐(GfO) 9 ), capable of dual‐modal imaging with MRI and NIR II, for targeted delivery of IDDMT inhibitors to repair AF damage and slow the progression of IDD is developed. In vitro and in vivo experiments have confirmed the effectiveness of UMZG in restoring mitochondrial dynamics, reducing ROS production, inflammation, and cell apoptosis. This innovative therapeutic approach, which integrates dual‐modal imaging capabilities, offers a new avenue for the early treatment of IDD.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/adhm.202502795
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.202502795
- OA Status
- bronze
- References
- 56
- OpenAlex ID
- https://openalex.org/W4416785729
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- Title
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Targeting MT‐tsRNA IDDMT with Nanoparticles to Annulus Fibrosus: A Novel Therapeutic Approach for Intervertebral Disc DegenerationWork title
- Type
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
- Publication date
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2025-11-28Full publication date if available
- Authors
-
Changxiong Cai, Yameng Wang, Zhiwen Wu, Shengqin Li, Jiangminghao Zhao, Tao Li, Xigao ChengList of authors in order
- Landing page
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https://doi.org/10.1002/adhm.202502795Publisher landing page
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.202502795Direct OA link when available
- Cited by
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0Total citation count in OpenAlex
- References (count)
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56Number of works referenced by this work
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| abstract_inverted_index.fibrosus | 2 |
| abstract_inverted_index.reducing | 149 |
| abstract_inverted_index.targeted | 36, 116 |
| abstract_inverted_index.unclear, | 24 |
| abstract_inverted_index.apoptosis | 85 |
| abstract_inverted_index.approach, | 159 |
| abstract_inverted_index.confirmed | 140 |
| abstract_inverted_index.diagnosis | 34 |
| abstract_inverted_index.dynamics, | 148 |
| abstract_inverted_index.interacts | 69 |
| abstract_inverted_index.molecular | 19 |
| abstract_inverted_index.restoring | 146 |
| abstract_inverted_index.signaling | 75 |
| abstract_inverted_index.treatment | 172 |
| abstract_inverted_index.Currently, | 17 |
| abstract_inverted_index.activating | 72 |
| abstract_inverted_index.apoptosis. | 155 |
| abstract_inverted_index.developed. | 132 |
| abstract_inverted_index.inhibitors | 120 |
| abstract_inverted_index.innovative | 157 |
| abstract_inverted_index.integrates | 161 |
| abstract_inverted_index.mechanisms | 20 |
| abstract_inverted_index.protrusion | 11 |
| abstract_inverted_index.circulatory | 41 |
| abstract_inverted_index.degenerated | 60 |
| abstract_inverted_index.experiments | 138 |
| abstract_inverted_index.nanocarrier | 94 |
| abstract_inverted_index.production, | 83, 151 |
| abstract_inverted_index.progression | 128 |
| abstract_inverted_index.significant | 7 |
| abstract_inverted_index.therapeutic | 158 |
| abstract_inverted_index.upregulated | 58 |
| abstract_inverted_index.degeneration | 15 |
| abstract_inverted_index.dual‐modal | 108, 162 |
| abstract_inverted_index.dysfunction, | 81 |
| abstract_inverted_index.capabilities, | 164 |
| abstract_inverted_index.effectiveness | 142 |
| abstract_inverted_index.inflammation, | 152 |
| abstract_inverted_index.mitochondrial | 80, 147 |
| abstract_inverted_index.significantly | 57 |
| abstract_inverted_index.(IDD‐related | 51 |
| abstract_inverted_index.intervertebral | 13, 64 |
| abstract_inverted_index.overexpression | 68 |
| abstract_inverted_index.Mechanistically, | 66 |
| abstract_inverted_index.mitochondria‐derived | 48 |
| abstract_inverted_index.mitochondrial‐derived | 52 |
| abstract_inverted_index.mt‐TRF3‐24‐AspGTC), | 54 |
| abstract_inverted_index.@MSN@ZIF‐8@IN‐IDDMT@Suc‐(GfO) | 103 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| citation_normalized_percentile |