Targeting Neutrophil Extracellular Traps in Gouty Arthritis: Insights into Pathogenesis and Therapeutic Potential Article Swipe
Cantao Li
,
Chenxi Wu
,
Fenfen Li
,
Wenjing Xu
,
Xiaoxi Zhang
,
Yan Huang
,
Daozong Xia
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.2147/jir.s460333
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.2147/jir.s460333
Gouty arthritis (GA) is an immune-mediated disorder characterized by severe inflammation due to the deposition of monosodium urate (MSU) crystals in the joints. The pathophysiological mechanisms of GA are not yet fully understood, and therefore, the identification of effective therapeutic targets is of paramount importance. Neutrophil extracellular traps (NETs), an intricate structure of DNA scaffold, encompassing myeloperoxidase, histones, and elastases - have gained significant attention as a prospective therapeutic target for gouty arthritis, due to their innate antimicrobial and immunomodulatory properties. Hence, exploring the therapeutic potential of NETs in gouty arthritis remains an enticing avenue for further investigation. During the process of gouty arthritis, the formation of NETs triggers the release of inflammatory cytokines, thereby contributing to the inflammatory response, while MSU crystals and cytokines are sequestered and degraded by the aggregation of NETs. Here, we provide a concise summary of the inflammatory processes underlying the initiation and resolution of gouty arthritis mediated by NETs. Furthermore, this review presents an overview of the current pharmacological approaches for treating gouty arthritis and summarizes the potential of natural and synthetic product-based inhibitors that target NET formation as novel therapeutic options, alongside elucidating the intrinsic challenges of these inhibitors in NETs research. Lastly, the limitations of HL-60 cell as a suitable substitute of neutrophils in NETs research are summarized and discussed. Series of recommendations are provided, strategically oriented towards guiding future investigations to effectively address these concerns. These findings will contribute to an enhanced comprehension of the interplay between NETs and GA, facilitating the proposition of innovative therapeutic strategies and novel approaches for the management of GA.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2147/jir.s460333
- https://www.dovepress.com/getfile.php?fileID=97716
- OA Status
- gold
- Cited By
- 17
- References
- 311
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4392957092
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4392957092Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.2147/jir.s460333Digital Object Identifier
- Title
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Targeting Neutrophil Extracellular Traps in Gouty Arthritis: Insights into Pathogenesis and Therapeutic PotentialWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-03-01Full publication date if available
- Authors
-
Cantao Li, Chenxi Wu, Fenfen Li, Wenjing Xu, Xiaoxi Zhang, Yan Huang, Daozong XiaList of authors in order
- Landing page
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https://doi.org/10.2147/jir.s460333Publisher landing page
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https://www.dovepress.com/getfile.php?fileID=97716Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.dovepress.com/getfile.php?fileID=97716Direct OA link when available
- Concepts
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Neutrophil extracellular traps, Arthritis, Inflammatory arthritis, Inflammation, Medicine, Gouty arthritis, Gout, Immunology, Computational biology, Biology, Internal medicineTop concepts (fields/topics) attached by OpenAlex
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17Total citation count in OpenAlex
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2025: 8, 2024: 9Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| citation_normalized_percentile.value | 0.96690289 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |