Targeting the immune-suppressive tumor microenvironment to potentiate CAR T cell therapy Article Swipe

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Tiffany C. Y. Tang , Ning Xu , Alla Dolnikov ·

YOU? · · 2020 · Open Access · · DOI: https://doi.org/10.15761/crr.1000203

Chimeric antigen receptor (CAR) T cell therapy is a promising new immunotherapy that reprograms patient T lymphocytes to specifically recognize and kill tumor cells.CAR T cell therapy has produced some dramatic responses in acute lymphoblastic leukemia and lymphomas, but responses have been less spectacular in solid tumors.To make CAR T cell therapy effective for solid tumors, CAR T cells must overcome an immune-suppressive tumor microenvironment (TME) that attenuates CAR T cell function.This review provides insights into mechanisms of CAR T cell therapy resistance with respect to the TME and offers strategies for improving CAR T cell therapy by targeting immune-suppressive factors in tumors.

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Tumor microenvironment Immune system CAR T-cell therapy Cancer research T cell Medicine Immunology Chimeric antigen receptor

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Type: article
Language: en
Landing Page: https://doi.org/10.15761/crr.1000203
PDF: https://www.oatext.com/pdf/CRR-4-203.pdf
OA Status: diamond
Cited By: 2
References: 95
Related Works: 10
OpenAlex ID: https://openalex.org/W3033535133

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OpenAlex ID: https://openalex.org/W3033535133

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DOI: https://doi.org/10.15761/crr.1000203

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Title: Targeting the immune-suppressive tumor microenvironment to potentiate CAR T cell therapy

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Type: article

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Language: en

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Publication year: 2020

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Publication date: 2020-01-01

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Authors: Tiffany C. Y. Tang, Ning Xu, Alla Dolnikov

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Landing page: https://doi.org/10.15761/crr.1000203

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Concepts: Tumor microenvironment, Immune system, CAR T-cell therapy, Cancer research, T cell, Medicine, Immunology, Chimeric antigen receptor

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Cited by: 2

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Citations by year (recent): 2025: 1, 2022: 1

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